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Praziquantel Disease Interactions

There are 4 disease interactions with praziquantel:

Major

Praziquantel (applies to praziquantel) cysticercosis

Major Potential Hazard, High plausibility.

Since parasite destruction within the eye can cause irreparable lesions, ocular cysticercosis should not be treated with praziquantel.

References

  1. Bada JL, Trevino B, Cabezos J "Convulsive seizures after treatment with praziquantel." Br Med J (Clin Res Ed) 296 (1988): 646
  2. Markwalder K, Hess K, Valavanis A, Witassek F "Cerebral cysticercosis: treatment with praziquantel. Report of two cases." Am J Trop Med Hyg 33 (1984): 273-80
  3. "Product Information. Biltricide (praziquantel)." Bayer, West Haven, CT.
  4. Leblanc R, Knowles KF, Melanson D, MacLean JD, Rouleau G, Farmer JP "Neurocysticercosis: surgical and medical management with praziquantel." Neurosurgery 18 (1986): 419-27
  5. Flisser A, Madrazo I, Plancarte A, Schantz P, Allan J, Craig P, Sarti E "Neurological symptoms in occult neurocysticercosis after single taeniacidal dose of praziquantel." Lancet 342 (1993): 748
View all 5 references
Major

Praziquantel (applies to praziquantel) epilepsy

Major Potential Hazard, Moderate plausibility. Applicable conditions: Seizures

Praziquantel can exacerbate central nervous system pathology due to schistosomiasis. As a general rule this drug should not be administered in individuals with a history of epilepsy or seizures and any other signs of potential central nervous system involvement such as subcutaneous nodules suggestive of cysticercosis.

Moderate

Praziquantel (applies to praziquantel) arrhythmias

Moderate Potential Hazard, Moderate plausibility.

Patients suffering from cardiac irregularities such as arrhythmias should be monitored during treatment with praziquantel.

Moderate

Praziquantel (applies to praziquantel) liver impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Caution should be exercised when administering praziquantel at the usual recommended doses in patients with moderate to severe liver impairment (Child Pugh class B and C). Reduced metabolism of praziquantel may lead to considerably higher and longer lasting plasma concentrations of the unmetabolized drug.

Praziquantel drug interactions

There are 81 drug interactions with praziquantel

Praziquantel alcohol/food interactions

There is 1 alcohol/food interaction with praziquantel

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.