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Potassium phosphate Disease Interactions

There are 4 disease interactions with potassium phosphate:


Phosphates (applies to potassium phosphate) hypocalcemia

Major Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction, Pancreatitis, Hypoparathyroidism, Hyperkalemia, Phosphate Imbalance

The use of phosphates is in general contraindicated in conditions where high potassium, high phosphate, or low calcium may be encountered such as hypoparathyroidism, osteomalacia, acute pancreatitis, or chronic renal disease.


  1. "Product Information. K-Phos Neutral (potassium phosphate)." Beach Pharmaceuticals, Tampa, FL.
  2. "Product Information. Fleet Enema (sodium biphosphate-sodium phosphate)." Fleet, Lynchburg, VA.

Potassium phosphate (applies to potassium phosphate) aluminum toxicity/renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Prematurity/Underweight in Infancy

Potassium phosphate injections contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration in patients with renal impairment. Preterm infants are particularly at risk for aluminum toxicity because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which also contain aluminum. Patients with renal impairment, including preterm infants, who receive greater than 4 to 5 mcg/kg/day of parenteral aluminum can accumulate aluminum to levels associated with central nervous system and bone toxicity. Potassium phosphate injection for parenteral nutrition is not recommended in adults weighing less than 45 kg or pediatric patients less than 12 years of age or weighing less than 40 kg due to the risks of aluminum toxicity.


Potassium phosphate (applies to potassium phosphate) cardiac disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Heart Disease

Potassium phosphate injection may increase the risk of hyperkalemia. Patients with cardiac disease may be more susceptible to the effects of hyperkalemia. Caution is advised when using potassium phosphates in patients with heart disease. Continuous electrocardiographic (ECG) monitoring is recommended for higher infusion rates of potassium.


Potassium phosphate (applies to potassium phosphate) hypomagnesemia

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Magnesium Imbalance, Hypercalcemia, Diabetic Ketoacidosis

Intravenous infusion of phosphate has been reported to cause a decrease in serum magnesium (and calcium) concentrations when administered to patients with hypercalcemia and diabetic ketoacidosis. Monitor serum magnesium concentrations during treatment. Caution is advised in patients with magnesium imbalances.

Potassium phosphate drug interactions

There are 65 drug interactions with potassium phosphate

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.