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Trental (pentoxifylline) Disease Interactions

There are 3 disease interactions with Trental (pentoxifylline):

Major

Pentoxifylline (applies to Trental) cerebral or retinal hemorrhage

Major Potential Hazard, Moderate plausibility. Applicable conditions: Intracranial Hemorrhage

The use of pentoxifylline is contraindicated in patients with recent cerebral and/or retinal hemorrhage. Dose-related hemorrhagic effects can occur.

References

  1. "Product Information. Trental (pentoxifylline)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Moderate

Pentoxifylline (applies to Trental) cardiovascular dysfunction

Moderate Potential Hazard, Low plausibility. Applicable conditions: Ischemic Heart Disease, Arrhythmias, Cerebral Vascular Disorder

Although pentoxifylline has been used safely to treat peripheral arterial disease in patients with concurrent coronary artery and cerebrovascular diseases, there have been occasional reports of angina, arrhythmia, and hypotension. Controlled trials do not show a causal relationship; however, since pentoxifylline is a methylxanthine derivative, the possibility of these adverse effects should be considered. Therapy with pentoxifylline should be administered cautiously in patients with arrhythmia, coronary artery and/or cerebrovascular insufficiency.

References

  1. "Product Information. Trental (pentoxifylline)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Moderate

Pentoxifylline (applies to Trental) hepatic/renal

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Liver Disease

In patients with hepatic or renal impairment, the exposure to pentoxifylline and/or active metabolites is increased. The consequences of the increase in drug exposure are not known. Caution is advised. Care should be taken in dose selection, and it may be useful to monitor renal and hepatic function.

Trental (pentoxifylline) drug interactions

There are 239 drug interactions with Trental (pentoxifylline)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.