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Neomycin / polymyxin b topical Disease Interactions

There are 2 disease interactions with neomycin / polymyxin b topical:


Neomycin (otic) (Includes neomycin/polymyxin b topical) ↔ perforated tympanic membrane

Severe Potential Hazard, High plausibility. Applies to: Perforated Tympanic Membrane

Like other aminoglycosides, neomycin is potentially ototoxic, both to vestibular and to auditory functions. Therapy with neomycin otic preparations should be administered cautiously in patients with chronic otitis media or a perforated tympanic membrane. The risk of ototoxicity may be increased if medication enters the middle ear.


  1. "Product Information. Mycifradin (neomycin)." Emerson Laboratories, Texarkana, TX.

Topical aminoglycosides (Includes neomycin/polymyxin b topical) ↔ burns

Moderate Potential Hazard, High plausibility. Applies to: Burns - External

Topical aminoglycosides should not be used on serious burns. When applied locally, aminoglycosides are generally not absorbed to a significant extent through intact skin but readily absorbed through denuded, burned, or granulating skin. Systemic adverse effects of aminoglycosides include nephrotoxicity and ototoxicity to vestibular and auditory functions. In general, topical aminoglycosides should not be used on large areas of the body or for more than 7 days without medical supervision.


  1. "Product Information. Myciguent (neomycin topical)." Pharmacia and Upjohn, Kalamazoo, MI.

Neomycin / polymyxin b topical drug interactions

There are 21 drug interactions with neomycin / polymyxin b topical

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.