Neomycin / polymyxin b topical Disease Interactions
There are 2 disease interactions with neomycin / polymyxin b topical:
Neomycin (Otic) (Includes Neomycin/polymyxin b topical) ↔ Perforated Tympanic Membrane
Severe Potential Hazard, High plausibility
Applies to: Perforated Tympanic Membrane
Like other aminoglycosides, neomycin is potentially ototoxic, both to vestibular and to auditory functions. Therapy with neomycin otic preparations should be administered cautiously in patients with chronic otitis media or a perforated tympanic membrane. The risk of ototoxicity may be increased if medication enters the middle ear.
- "Product Information. Mycifradin (neomycin)." Emerson Laboratories, Texarkana, TX.
Topical Aminoglycosides (Includes Neomycin/polymyxin b topical) ↔ Burns
Moderate Potential Hazard, High plausibility
Applies to: Burns - External
Topical aminoglycosides should not be used on serious burns. When applied locally, aminoglycosides are generally not absorbed to a significant extent through intact skin but readily absorbed through denuded, burned, or granulating skin. Systemic adverse effects of aminoglycosides include nephrotoxicity and ototoxicity to vestibular and auditory functions. In general, topical aminoglycosides should not be used on large areas of the body or for more than 7 days without medical supervision.
- "Product Information. Myciguent (neomycin topical)." Pharmacia and Upjohn, Kalamazoo, MI.
neomycin / polymyxin b topical drug Interactions
There are 20 drug interactions with neomycin / polymyxin b topical
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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