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Methylene blue Disease Interactions

There are 2 disease interactions with methylene blue:


Methylene blue (Includes methylene blue) ↔ methemoglobinemia in G-6-PD

Severe Potential Hazard, High plausibility. Applies to: G-6-PD Deficiency

The use of methylene blue is contraindicated for the treatment of methemoglobinemia in patients with glucose-6-phosphate deficiency (G-6-PD). Methylene blue will not reverse the condition in patients with G-6-PD and may precipitate acute hemolysis in these patients.


  1. "Product Information. Urised Tablets (methylene blue)." Polymedica Pharmaceuticals USA Inc, Woburn, MA.

Methylene blue (Includes methylene blue) ↔ renal dysfunction

Moderate Potential Hazard, High plausibility. Applies to: Renal Dysfunction

Methylene blue is reduced in tissues to leukomethylene blue, and both are excreted by the kidney. The serum concentrations of methylene blue and leukomethylene blue may be increased in patients with impaired renal function. Therapy with methylene blue should be avoided in patients with severe renal impairment and administered cautiously in patients with mild to moderate renal impairment. Dosage adjustments may be necessary.


  1. "Product Information. Urised Tablets (methylene blue)." Polymedica Pharmaceuticals USA Inc, Woburn, MA.

Methylene blue drug interactions

There are 579 drug interactions with methylene blue

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.