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Methylene blue Disease Interactions

There are 2 disease interactions with methylene blue.


Methylene blue (applies to methylene blue) methemoglobinemia in G-6-PD

Major Potential Hazard, High plausibility. Applicable conditions: G-6-PD Deficiency

The use of methylene blue is contraindicated for the treatment of methemoglobinemia in patients with glucose-6-phosphate deficiency (G-6-PD). Methylene blue will not reverse the condition in patients with G-6-PD and may precipitate acute hemolysis in these patients.


  1. "Product Information. Urised (hyoscyamine/methenam/m-blue/phenyl salicyl)." Polymedica Pharmaceuticals USA Inc (2022):

Methylene blue (applies to methylene blue) renal dysfunction

Moderate Potential Hazard, High plausibility.

Methylene blue is reduced in tissues to leukomethylene blue, and both are excreted by the kidney. The serum concentrations of methylene blue and leukomethylene blue may be increased in patients with impaired renal function. Therapy with methylene blue should be avoided in patients with severe renal impairment and administered cautiously in patients with mild to moderate renal impairment. Dosage adjustments may be necessary.


  1. "Product Information. Urised (hyoscyamine/methenam/m-blue/phenyl salicyl)." Polymedica Pharmaceuticals USA Inc (2022):

Methylene blue drug interactions

There are 192 drug interactions with methylene blue.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.