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Luspatercept Disease Interactions

There are 3 disease interactions with luspatercept.

Moderate

Luspatercept (applies to luspatercept) renal/liver

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease, Renal Dysfunction

Pharmacokinetic studies of luspatercept demonstrated no clinically significant differences in patients with mild to severe hepatic impairment and in patients with mild to moderate renal impairment. The effect of severe renal impairment on luspatercept pharmacokinetics is unknown. Care is recommended.

Moderate

Luspatercept (applies to luspatercept) thromboembolism

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Thrombotic/Thromboembolic Disorder

Thromboembolic events (TEE) have been reported in luspatercept-treated patients with beta-thalassemia. Patients with known risk factors for thromboembolism may be at increased risk of thromboembolic events. It is recommended to monitor patients for signs and symptoms of thromboembolic events and consider thromboprophylaxis in patients with beta-thalassemia at increased risk of TEE.

Moderate

Luspatercept – hypertension

Moderate Potential Hazard, Moderate plausibility.

The use of luspatercept may cause hypertension. It is recommended to monitor blood pressure before each dose administration. New-onset hypertension or exacerbation of preexisting hypertension should be managed with anti-hypertensive drugs as clinically appropriate.

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Luspatercept drug interactions

There are 2 drug interactions with luspatercept.

Luspatercept alcohol/food interactions

There is 1 alcohol/food interaction with luspatercept.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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