Luspatercept Disease Interactions
There are 3 disease interactions with luspatercept.
Luspatercept (applies to luspatercept) renal/liver
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease, Renal Dysfunction
Pharmacokinetic studies of luspatercept demonstrated no clinically significant differences in patients with mild to severe hepatic impairment and in patients with mild to moderate renal impairment. The effect of severe renal impairment on luspatercept pharmacokinetics is unknown. Care is recommended.
Luspatercept (applies to luspatercept) thromboembolism
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Thrombotic/Thromboembolic Disorder
Thromboembolic events (TEE) have been reported in luspatercept-treated patients with beta-thalassemia. Patients with known risk factors for thromboembolism may be at increased risk of thromboembolic events. It is recommended to monitor patients for signs and symptoms of thromboembolic events and consider thromboprophylaxis in patients with beta-thalassemia at increased risk of TEE.
Luspatercept – hypertension
Moderate Potential Hazard, Moderate plausibility.
The use of luspatercept may cause hypertension. It is recommended to monitor blood pressure before each dose administration. New-onset hypertension or exacerbation of preexisting hypertension should be managed with anti-hypertensive drugs as clinically appropriate.
Luspatercept drug interactions
There are 2 drug interactions with luspatercept.
Luspatercept alcohol/food interactions
There is 1 alcohol/food interaction with luspatercept.
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- Drug class: miscellaneous erythropoiesis agents
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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