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Levonordefrin/mepivacaine Disease Interactions

There are 2 disease interactions with levonordefrin / mepivacaine.

Moderate

Levonordefrin (applies to levonordefrin/mepivacaine) vasoconstrictor

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Heart Disease, Cardiovascular Disease, Thyrotoxicosis, Diabetes Mellitus

Compounds containing levonordefrin, a sympathomimetic amine used as a vasoconstrictor in local anesthetic solutions, should be used with extreme caution in the presence of disease which may adversely affect the patient's cardiovascular system. Close monitoring is recommended in patients whose medical history and physical evaluation suggest the existence of hypertension, arteriosclerotic heart disease, cerebral vascular insufficiency, heart block, thyrotoxicosis, and diabetes.

Moderate

Mepivacaine (applies to levonordefrin/mepivacaine) arrhythmias

Moderate Potential Hazard, Moderate plausibility.

Mepivacaine should be used with caution in patients with a history of severe disturbances of cardiac rhythm or heart block. Care should be exercised when using this agent in patients with theses conditions.

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Levonordefrin/mepivacaine drug interactions

There are 246 drug interactions with levonordefrin / mepivacaine.

Levonordefrin/mepivacaine alcohol/food interactions

There is 1 alcohol/food interaction with levonordefrin / mepivacaine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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