Interferon gamma-1b Disease Interactions
There are 3 disease interactions with interferon gamma-1b.
Interferons (applies to interferon gamma-1b) cardiac disease
Major Potential Hazard, High plausibility. Applicable conditions: Congestive Heart Failure, Ischemic Heart Disease, Arrhythmias
Hypertension, arrhythmias, angina, myocardial infarction, cardiomyopathy, and congestive heart failure have been reported during interferon therapy. Therapy with interferons should be administered with caution in patients with compromised cardiac function.
Interferons (applies to interferon gamma-1b) CNS dysfunction
Major Potential Hazard, High plausibility. Applicable conditions: Parkinsonism, Seizures, Psychosis
Reversible CNS effects such as seizures, mental status changes, manic behavior or psychotic reactions, gait disturbances, and dizziness have occurred in patients receiving interferons. Therapy with interferons should be administered cautiously in patients with or predisposed to seizures, psychiatric disorders, or conditions affecting posture or gait.
Interferons (applies to interferon gamma-1b) myelosuppression
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Bone Marrow Depression/Low Blood Counts
Interferons (alfa and gamma) induce a dose-dependent, generally mild, myelosuppression. Leukopenia is the primary manifestation. Thrombocytopenia and anemia occur less frequently. Therapy with interferons (alfa and gamma) should be administered cautiously to patients with bone marrow suppression. Clinical monitoring of hematopoietic function is recommended.
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Interferon gamma-1b drug interactions
There are 203 drug interactions with interferon gamma-1b.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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