Ifosfamide / mesna Disease Interactions
There are 3 disease interactions with ifosfamide / mesna:
Antineoplastics (Includes Ifosfamide/mesna) ↔ Infections
Severe Potential Hazard, High plausibility
Applies to: Infection - Bacterial/Fungal/Protozoal/Viral
Because of their cytotoxic effects on rapidly proliferating tissues, antineoplastic agents frequently can, to varying extent, induce myelosuppression. The use of these drugs may be contraindicated in patients with known infectious diseases. All patients should be instructed to immediately report any signs or symptoms suggesting infection such as fever, sore throat, or local infection during antineoplastic therapy. Close clinical monitoring of hematopoietic function is recommended.
- "Product Information. Novantrone (mitoxantrone)." Immunex Corporation, Seattle, WA.
- "Product Information. Gemzar (gemcitabine)." Lilly, Eli and Company, Indianapolis, IN.
- "Product Information. Taxol (paclitaxel)." Bristol-Myers Squibb, Princeton, NJ.
Mdvs (Includes Ifosfamide/mesna) ↔ Prematurity
Severe Potential Hazard, Moderate plausibility
Applies to: Prematurity/Underweight in Infancy
Parenteral medications formulated in multidose vials often contain benzyl alcohol as a preservative. Their use is considered by drug manufacturers to be contraindicated in neonates, particularly premature infants and infants of low birth weight. When used in bacteriostatic saline intravascular flush and endotracheal tube lavage solutions, benzyl alcohol has been associated with fatalities and severe respiratory and metabolic complications in low-birth-weight premature infants. Thus, single-dose formulations should always be used in infants whenever possible. However, many experts feel that, in the absence of benzyl alcohol-free equivalents, the amount of the preservative present in these formulations should not necessarily preclude their use if they are clearly indicated. The American Academy of Pediatrics considers benzyl alcohol in low doses (such as when used as a preservative in some medications) to be safe for newborns. However, the administration of high dosages of these medications must take into account the total amount of benzyl alcohol administered. The level at which toxicity may occur is unknown.
- ""Inactive" ingredients in pharmaceutical products: update (subject review). American Academy of Pediatrics Committee on Drugs. Available from: URL: http://www.aap.org/policy/re9706.html." Pediatrics 99 (1997): 268-78
- "Product Information. Fragmin (dalteparin)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Tracrium (atracurium)." Glaxo Wellcome, Research Triangle Park, NC.
Mesna (Includes Ifosfamide/mesna) ↔ Autoimmune Disorders
Severe Potential Hazard, Moderate plausibility
Applies to: Autoimmune Disorder
Mesna is a thiol (SH) compound. Hypersensitivity reactions including anaphylaxis have occurred in patients with autoimmune disorders, the majority of whom received high dosages of mesna orally. Therapy with mesna should be administered cautiously in patients with autoimmune disorders.
- Reinhold-Keller E, Mohr J, Christophers E, Nordmann K, Gross WL "Mesna side effects which imitate vasculitis." Clin Investig 70 (1992): 698-704
- Seidel A, Andrassy K, Ritz E, Kasser U, Lemmel EM "Allergic reactions to mesna." Lancet 338 (1991): 381
- "Product Information. Mesnex (mesna)." Bristol-Myers Squibb, Princeton, NJ.
ifosfamide / mesna drug Interactions
There are 756 drug interactions with ifosfamide / mesna
ifosfamide / mesna alcohol/food Interactions
There is 1 alcohol/food interaction with ifosfamide / mesna
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
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