Skip to main content

Hyoscyamine/methenamine Disease Interactions

There are 22 disease interactions with hyoscyamine / methenamine.

Major

Anticholinergics (applies to hyoscyamine/methenamine) autonomic neuropathy

Major Potential Hazard, High plausibility.

Agents with anticholinergic activity can exacerbate many of the manifestations of autonomic neuropathy, including tachycardia, anhidrosis, bladder atony, obstipation, dry mouth and eyes, cycloplegia and blurring of vision, and sexual impotence in males. Therapy with antimuscarinic agents and higher dosages of antispasmodic agents (e.g., dicyclomine or oxybutynin) should be administered cautiously in patients with autonomic neuropathy.

References

  1. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
Major

Anticholinergics (applies to hyoscyamine/methenamine) GI obstruction

Major Potential Hazard, High plausibility. Applicable conditions: Gastrointestinal Obstruction, Esophageal Obstruction

Anticholinergics are contraindicated in patients with obstructive diseases such as achalasia, esophageal stricture or stenosis, pyloroduodenal stenosis, stenosing peptic ulcer, pyloric obstruction, and paralytic ileus. Anticholinergics may further suppress intestinal motility with resultant precipitation or aggravation of toxic megacolon.

References

  1. Bantz EW, Dolen WK, Chadwick EW, Nelson HS (1987) "Chronic chlorpheniramine therapy: subsensitivity, drug metabolism, and compliance." Ann Allergy, 59, p. 341-6
  2. Simons FE, Frith EM, Simons KJ (1982) "The pharmacokinetics and antihistaminic effects of brompheniramine." J Allergy Clin Immunol, 70, p. 458-64
  3. Blamoutier J (1978) "Comparative trial of two antihistamines, mequitazine and brompheniramine." Curr Med Res Opin, 5, p. 366-70
  4. (1977) "Azatadine (optimine)--a new antihistamine." Med Lett Drugs Ther, 19, p. 77-9
  5. (2002) "Product Information. Dimetane (brompheniramine)." Wyeth-Ayerst Laboratories
  6. "Product Information. Chlor-Trimeton (chlorpheniramine)." Schering-Plough
  7. (2002) "Product Information. Periactin (cyproheptadine)." Merck & Co., Inc
  8. (2002) "Product Information. Benadryl (diphenhydramine)." Parke-Davis
  9. (2001) "Product Information. Phenergan (promethazine)." Wyeth-Ayerst Laboratories
  10. (2001) "Product Information. Tavist (clemastine)." Sandoz Pharmaceuticals Corporation
  11. (2001) "Product Information. Antivert (meclizine)." Roerig Division
  12. (2001) "Product Information. Optimine (azatadine)." Schering Corporation
  13. Mevorach D (1992) "Adverse effects of atropine sulfate autoinjection." Ann Pharmacother, 26, p. 564
  14. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
  15. (2001) "Product Information. Artane (trihexyphenidyl)." Lederle Laboratories
  16. (2001) "Product Information. Poly-Histine-D (pyrilamine)." Bock Pharmacal Company
View all 16 references
Major

Anticholinergics (applies to hyoscyamine/methenamine) glaucoma

Major Potential Hazard, High plausibility. Applicable conditions: Glaucoma/Intraocular Hypertension

Anticholinergic agents are contraindicated in patients with primary glaucoma, a tendency toward glaucoma (narrow anterior chamber angle), or adhesions (synechiae) between the iris and lens, as well as for the elderly and others in whom undiagnosed glaucoma or excessive pressure in the eye may be present. Because anticholinergics cause mydriasis, they may exacerbate these conditions.

References

  1. Schuller DE, Turkewitz D (1986) "Adverse effects of antihistamines." Postgrad Med, 79, p. 75-86
  2. (2002) "Product Information. Dimetane (brompheniramine)." Wyeth-Ayerst Laboratories
  3. "Product Information. Chlor-Trimeton (chlorpheniramine)." Schering-Plough
  4. (2002) "Product Information. Thorazine (chlorpromazine)." SmithKline Beecham
  5. (2002) "Product Information. Periactin (cyproheptadine)." Merck & Co., Inc
  6. (2002) "Product Information. Benadryl (diphenhydramine)." Parke-Davis
  7. (2001) "Product Information. Phenergan (promethazine)." Wyeth-Ayerst Laboratories
  8. (2001) "Product Information. Tavist (clemastine)." Sandoz Pharmaceuticals Corporation
  9. (2001) "Product Information. Optimine (azatadine)." Schering Corporation
  10. O'Connor PS, Mumma JV (1985) "Atropine toxicity." Am J Ophthalmol, 99, p. 613-4
  11. Clearkin LG (1992) "Angle closure glaucoma precipitated by atropine." Arch Intern Med, 152, p. 880
  12. Berdy GJ, Berdy SS, Odin LS, Hirst LW (1991) "Angle closure glaucoma precipitated by aerosolized atropine." Arch Intern Med, 151, p. 1658-60
  13. Pecora JL (1979) "Malignant glaucoma worsened by miotics in a postoperative angle- closure glaucoma patient." Ann Ophthalmol, 11, p. 1412-4
  14. Holland MG (1974) "Autonomic drugs in ophthalmology: some problems and promises. Section II: Anticholinergic drugs." Ann Ophthalmol, 6, p. 661-4
  15. Kanto J (1983) "New aspects in the use of atropine." Int J Clin Pharmacol Ther Toxicol, 21, p. 92-4
  16. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
  17. (2001) "Product Information. Compazine (prochlorperazine)." SmithKline Beecham
  18. Goldstein JH (1971) "Effects of drugs on cornea, conjunctiva, and lids." Int Ophthalmol Clin, 11, p. 13-34
  19. (2001) "Product Information. Cogentin (benztropine)." Merck & Co., Inc
  20. (2001) "Product Information. Artane (trihexyphenidyl)." Lederle Laboratories
  21. (2001) "Product Information. Moban (molindone)." Gate Pharmaceuticals
  22. "Product Information. Orap (pimozide)." Gate Pharmaceuticals
  23. (2001) "Product Information. Poly-Histine-D (pyrilamine)." Bock Pharmacal Company
View all 23 references
Major

Anticholinergics (applies to hyoscyamine/methenamine) obstructive uropathy

Major Potential Hazard, High plausibility. Applicable conditions: Urinary Retention

In general, the use of anticholinergic agents is contraindicated in patients with urinary retention and bladder neck obstruction caused by prostatic hypertrophy. Dysuria may occur and may require catheterization. Also, anticholinergic drugs may aggravate partial obstructive uropathy. Caution is advised even when using agents with mild to moderate anticholinergic activity, particularly in elderly patients.

References

  1. Bantz EW, Dolen WK, Chadwick EW, Nelson HS (1987) "Chronic chlorpheniramine therapy: subsensitivity, drug metabolism, and compliance." Ann Allergy, 59, p. 341-6
  2. Schuller DE, Turkewitz D (1986) "Adverse effects of antihistamines." Postgrad Med, 79, p. 75-86
  3. (2002) "Product Information. Dimetane (brompheniramine)." Wyeth-Ayerst Laboratories
  4. "Product Information. Chlor-Trimeton (chlorpheniramine)." Schering-Plough
  5. (2002) "Product Information. Thorazine (chlorpromazine)." SmithKline Beecham
  6. (2002) "Product Information. Periactin (cyproheptadine)." Merck & Co., Inc
  7. (2002) "Product Information. Benadryl (diphenhydramine)." Parke-Davis
  8. (2001) "Product Information. Phenergan (promethazine)." Wyeth-Ayerst Laboratories
  9. (2001) "Product Information. Tavist (clemastine)." Sandoz Pharmaceuticals Corporation
  10. (2001) "Product Information. Antivert (meclizine)." Roerig Division
  11. (2001) "Product Information. Optimine (azatadine)." Schering Corporation
  12. Shutt LE, Bowes JB (1979) "Atropine and hyoscine." Anaesthesia, 34, p. 476-90
  13. O'Kelly SW, Spargo PM (1991) "Postoperative urinary retention in men." BMJ, 302, p. 1403-4
  14. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
  15. (2001) "Product Information. Compazine (prochlorperazine)." SmithKline Beecham
  16. (2001) "Product Information. Zyrtec (cetirizine)." Pfizer U.S. Pharmaceuticals
  17. (2001) "Product Information. Artane (trihexyphenidyl)." Lederle Laboratories
  18. (2001) "Product Information. Moban (molindone)." Gate Pharmaceuticals
  19. "Product Information. Orap (pimozide)." Gate Pharmaceuticals
  20. (2001) "Product Information. Poly-Histine-D (pyrilamine)." Bock Pharmacal Company
View all 20 references
Major

Anticholinergics (applies to hyoscyamine/methenamine) reactive airway diseases

Major Potential Hazard, Moderate plausibility. Applicable conditions: Asthma

The use of systemic anticholinergics is contraindicated in the treatment of lower respiratory tract symptoms including asthma. Muscarinic receptor antagonists reduce bronchial secretions, which can result in decreased fluidity and increased thickening of secretions. However, ipratropium does not produce these effects and can be used safely in treating asthma.

References

  1. Nahata MC, Clotz MA, Krogg EA (1985) "Adverse effects of meperidine, promethazine, and chlorpromazine for sedation in pediatric patients." Clin Pediatr (Phila), 24, p. 558-60
  2. (2001) "Product Information. Phenergan (promethazine)." Wyeth-Ayerst Laboratories
  3. (2001) "Product Information. Antivert (meclizine)." Roerig Division
  4. (2001) "Product Information. Marezine (cyclizine)." Glaxo Wellcome
  5. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
View all 5 references
Major

Antimuscarinics (applies to hyoscyamine/methenamine) myasthenia gravis

Major Potential Hazard, Moderate plausibility.

Because antimuscarinic agents have anticholinergic effects, they are contraindicated in patients with myasthenia gravis. Their use may be appropriate to reduce adverse muscarinic effects caused by an anticholinesterase agent.

References

  1. Shutt LE, Bowes JB (1979) "Atropine and hyoscine." Anaesthesia, 34, p. 476-90
  2. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
  3. (2002) "Product Information. Bentyl (dicyclomine)." Aventis Pharmaceuticals
Major

Antiperistaltic agents (applies to hyoscyamine/methenamine) infectious diarrhea

Major Potential Hazard, High plausibility. Applicable conditions: Infectious Diarrhea/Enterocolitis/Gastroenteritis

The use of drugs with antiperistaltic activity (primarily antidiarrheal and antimuscarinic agents, but also antispasmodic agents such as dicyclomine or oxybutynin at high dosages) is contraindicated in patients with diarrhea due to pseudomembranous enterocolitis or enterotoxin-producing bacteria. These drugs may prolong and/or worsen diarrhea associated with organisms that invade the intestinal mucosa, such as toxigenic E. coli, Salmonella and Shigella, and pseudomembranous colitis due to broad-spectrum antibiotics. Other symptoms and complications such as fever, shedding of organisms and extraintestinal illness may also be increased or prolonged. In general, because antiperistaltic agents decrease gastrointestinal motility, they may delay the excretion of infective gastroenteric organisms or toxins and should be used cautiously in patients with any infectious diarrhea, particularly if accompanied by high fever or pus or blood in the stool. Some cough and cold and other combination products may occasionally include antimuscarinic agents for their drying effects and may, therefore, require careful selection when necessary.

References

  1. Brown JW (1979) "Toxic megacolon associated with loperamide therapy." JAMA, 241, p. 501-2
  2. Walley T, Milson D (1990) "Loperamide related toxic megacolon in Clostridium difficile colitis." Postgrad Med J, 66, p. 582
  3. (2001) "Product Information. Imodium (loperamide)." Janssen Pharmaceuticals
  4. Marshall WF Jr, Rosenthal P, Merritt RJ (1989) "Atropine therapy and paralytic ileus in an infant." J Pediatr Gastroenterol Nutr, 9, p. 532-4
  5. (1975) "Lomotil for diarrhea in children." Med Lett Drugs Ther, 17, p. 104
  6. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
View all 6 references
Major

Methenamine (applies to hyoscyamine/methenamine) crystalluria

Major Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction, Dehydration

The use of methenamine salts (i.e. methenamine hippurate or mandelate), but not the base, is contraindicated in patients with severe renal impairment or dehydration. Methenamine is excreted by the kidney and concentrated in the urine. In patients with low urinary output, the salts can precipitate and cause crystalluria.

References

  1. Klinge E, Mannisto P, Mantyla R, Lamminsivu U, Ottoila P (1982) "Pharmacokinetics of methenamine in healthy volunteers." J Antimicrob Chemother, 9, p. 209-16
  2. Gleckman R, Alvarez S, Joubert D, Matthews S (1979) "Drug therapy reviews: methenamine mandelate and methenamine hippurate." Am J Hosp Pharm, 36, p. 1509-12
  3. Australian Drug Evaluation Committee (1972) "Adverse effects of drugs commonly used in the treatment of urinary tract infection." Med J Aust, 1, p. 435-8
  4. (2002) "Product Information. Hiprex (methenamine)." Hoechst Marion Roussel
  5. (2002) "Product Information. Mandelamine (methenamine)." Parke-Davis
  6. American Medical Association, Division of Drugs and Toxicology (1994) "Drug evaluations annual 1994." Chicago, IL: American Medical Association;
View all 6 references
Major

Methenamine (applies to hyoscyamine/methenamine) gout

Major Potential Hazard, Moderate plausibility.

Methenamine mandelate (salts), should be avoided in patients with gout as it may precipitate urate crystals in their urine. A similar situation may arise in patients with a predisposition to the formation of uric acid stones.

References

  1. (2002) "Product Information. Hiprex (methenamine)." Hoechst Marion Roussel
Major

Methenamine (applies to hyoscyamine/methenamine) liver disease

Major Potential Hazard, High plausibility.

The use of methenamine and its salts (i.e. methenamine hippurate or mandelate) is contraindicated in patients with severe hepatic impairment. Methenamine is hydrolyzed to ammonia and formaldehyde in the urine under acidic conditions. Patients with liver disease may already have elevated ammonia levels, which can cause or exacerbate hepatic encephalopathy. Methenamine hippurate has also been associated with isolated cases of transient elevations in serum transaminases. The manufacturer recommends periodic liver function tests during therapy, particularly in patients with preexisting liver dysfunction.

References

  1. Strom J, Jun H (1975) "Kinetics of hydrolysis of methenamine." Pharm Bull, 23, p. 651
  2. Gleckman R, Alvarez S, Joubert D, Matthews S (1979) "Drug therapy reviews: methenamine mandelate and methenamine hippurate." Am J Hosp Pharm, 36, p. 1509-12
  3. (2002) "Product Information. Hiprex (methenamine)." Hoechst Marion Roussel
  4. (2002) "Product Information. Mandelamine (methenamine)." Parke-Davis
  5. American Medical Association, Division of Drugs and Toxicology (1994) "Drug evaluations annual 1994." Chicago, IL: American Medical Association;
View all 5 references
Moderate

Anticholinergics (applies to hyoscyamine/methenamine) cardiac disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Cardiovascular Disease

Anticholinergics block vagal inhibition of the SA nodal pacemaker. Therapy with anticholinergics should be administered cautiously to patients with tachycardia, congestive heart failure, or coronary artery disease. Premature ventricular depolarization, ventricular tachycardia, and fibrillation associated with anticholinergics are rare.

References

  1. Schuller DE, Turkewitz D (1986) "Adverse effects of antihistamines." Postgrad Med, 79, p. 75-86
  2. Lowenthal DT, Reidenberg MM (1972) "The heart rate response to atropine in uremic patients, obese subjects before and during fasting, and patients with other chronic illnesses." Proc Soc Exp Biol Med, 139, p. 390-3
  3. (2002) "Product Information. Benadryl (diphenhydramine)." Parke-Davis
  4. (2001) "Product Information. Tavist (clemastine)." Sandoz Pharmaceuticals Corporation
  5. (2001) "Product Information. Antivert (meclizine)." Roerig Division
  6. Lunde P (1976) "Ventricular fibrillation after intravenous atropine for treatment of sinus bradycardia." Acta Med Scand, 199, p. 369-71
  7. Cooper MJ, Abinader EG (1979) "Atropine-induced ventricular fibrillation: case report and review of the literature." Am Heart J, 97, p. 225-8
  8. Das G, Talmers FN, Weissler AM (1975) "New observations on the effects of atropine on the sinoatrial and atrioventricular nodes in man." Am J Cardiol, 36, p. 281-5
  9. Knoebel SB, McHenry PL, Phillips JF, Widlansky S (1974) "Atropine-induced cardioacceleration and myocardial blood flow in subjects with and without coronary artery disease." Am J Cardiol, 33, p. 327-32
  10. Bradshaw EG (1976) "Dysrhythmias associated with oral surgery." Anaesthesia, 31, p. 13-7
  11. Horgan J (1973) "Atropine and ventricular tachyarrhythmia." JAMA, 223, p. 693
  12. Zsigmond EK, Matsuki A, Sharafabadi C (1973) "Atropine and cardiac arrhythmia." N Engl J Med, 288, p. 635
  13. Massumi RA, Mason DT, Amsterdam EA, DeMaria A, Miller RR, Scheinman MM, Zelis R (1972) "Ventricular fibrillation and tachycardia after intravenous atropine for treatment of bradycardias." N Engl J Med, 287, p. 336-8
  14. Valentin N, Staffeldt H, Kyst A (1984) "Effect of i.v. atropine on cardiac rhythm, heart rate, blood pressure and airway secretion during isoflurane anaesthesia." Acta Anaesthesiol Scand, 28, p. 621-4
  15. Lazzari JO, Benchuga EG, Elizari MV, Rosenbaum MB (1982) "Ventricular fibrillation after intravenous atropine in a patient with atrioventricular block." Pacing Clin Electrophysiol, 5, p. 196-200
  16. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
View all 16 references
Moderate

Anticholinergics (applies to hyoscyamine/methenamine) tachycardia

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Arrhythmias

Anticholinergics block vagal inhibition of the SA nodal pacemaker. Therapy with anticholinergics should be administered cautiously in patients with tachycardia, congestive heart failure, or coronary artery disease. Premature ventricular depolarization or ventricular tachycardia or fibrillation associated with anticholinergics is rare.

References

  1. (2001) "Product Information. Antivert (meclizine)." Roerig Division
Moderate

Antimuscarinics (applies to hyoscyamine/methenamine) coronary artery disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Arrhythmias, Ischemic Heart Disease

Antimuscarinic agents block vagal inhibition of the SA nodal pacemaker. These agents should be administered cautiously in patients with tachycardia, congestive heart failure, or coronary artery disease. Premature ventricular depolarization or ventricular tachycardia or fibrillation associated with antimuscarinic drugs is rare.

References

  1. Lunde P (1976) "Ventricular fibrillation after intravenous atropine for treatment of sinus bradycardia." Acta Med Scand, 199, p. 369-71
  2. Knoebel SB, McHenry PL, Phillips JF, Widlansky S (1974) "Atropine-induced cardioacceleration and myocardial blood flow in subjects with and without coronary artery disease." Am J Cardiol, 33, p. 327-32
  3. Richman S (1974) "Adverse effect of atropine during myocardial infarction. Enchancement of ischemia following intravenously administered atropine." JAMA, 228, p. 1414-6
  4. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
  5. (2002) "Product Information. Bentyl (dicyclomine)." Aventis Pharmaceuticals
View all 5 references
Moderate

Antimuscarinics (applies to hyoscyamine/methenamine) gastric ulcer

Moderate Potential Hazard, Low plausibility. Applicable conditions: Bleeding

Antimuscarinic agents may cause a delay in gastric emptying and possibly antral stasis in patients with gastric ulcer. Therapy with antimuscarinic agents should be administered cautiously to patients with gastric ulcer.

References

  1. Chernish SM, Brunelle RR, Rosenak BD, Ahmadzai S (1978) "Comparison of the effects of glucagon and atropine sulfate on gastric emptying." Am J Gastroenterol, 70, p. 581-6
  2. Mevorach D (1992) "Adverse effects of atropine sulfate autoinjection." Ann Pharmacother, 26, p. 564
  3. Cotton BR, Smith G (1981) "Single and combined effects of atropine and metoclopramide on the lower oesophageal sphincter pressure." Br J Anaesth, 53, p. 869-74
  4. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
View all 4 references
Moderate

Antimuscarinics (applies to hyoscyamine/methenamine) gastroesophageal reflux

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Gastroesophageal Reflux Disease

Antimuscarinic agents decrease gastric motility and relax the lower esophageal sphincter which promotes gastric retention and can aggravate reflux. These drugs should be administered cautiously in patients with gastroesophageal reflux or hiatal hernia associated with reflux esophagitis.

References

  1. Chernish SM, Brunelle RR, Rosenak BD, Ahmadzai S (1978) "Comparison of the effects of glucagon and atropine sulfate on gastric emptying." Am J Gastroenterol, 70, p. 581-6
  2. Dow TG, Brock-Utne JG, Rubin J, Welman S, Dimopoulos GE, Moshal MG (1978) "The effect of atropine on the lower esophageal sphincter in late pregnancy." Obstet Gynecol, 51, p. 426-30
  3. Howells TH (1977) "The administration of metoclopramide with atropine." Anaesthesia, 32, p. 677
  4. Brock-Utne JG, Rubin J, Downing JW, Dimopoulos GE, Moshal MG, Naicker M (1976) "The administration of metoclopramide with atropine. A drug interaction effect on the gastro-oesophageal sphincter in man." Anaesthesia, 31, p. 1186-90
  5. Cotton BR, Smith G (1981) "Single and combined effects of atropine and metoclopramide on the lower oesophageal sphincter pressure." Br J Anaesth, 53, p. 869-74
  6. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
View all 6 references
Moderate

Antimuscarinics (applies to hyoscyamine/methenamine) ulcerative colitis

Moderate Potential Hazard, Moderate plausibility.

Antimuscarinic agents may suppress intestinal motility and produce paralytic ileus with resultant precipitation of toxic megacolon. These drugs should be administered cautiously to patients with ulcerative colitis.

References

  1. Famewo CE (1977) "A re-evaluation of anticholergic premedication." Can Anaesth Soc J, 24, p. 39-41
  2. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
  3. Braunwald E, Hauser SL, Kasper DL, Fauci AS, Isselbacher KJ, Longo DL, Martin JB, eds., Wilson JD (1998) "Harrison's Principles of Internal Medicine." New York, NY: McGraw-Hill Health Professionals Division
  4. (2002) "Product Information. Bentyl (dicyclomine)." Aventis Pharmaceuticals
View all 4 references
Moderate

Atropine-like agents (applies to hyoscyamine/methenamine) liver disease

Moderate Potential Hazard, Moderate plausibility.

Atropine-like agents undergo significant hepatic metabolism. Therapy with atropine-like agents should be administered cautiously to patients with liver disease.

References

  1. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
Moderate

Atropine-like agents (applies to hyoscyamine/methenamine) renal failure

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Atropine-like agents are primarily eliminated by the kidney. Therapy with atropine-like agents should be administered cautiously to patients with renal disease.

References

  1. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
Minor

Anticholinergics (applies to hyoscyamine/methenamine) hypertension

Minor Potential Hazard, Low plausibility.

Cardiovascular effects of anticholinergics may exacerbate hypertension. Therapy with anticholinergic agents should be administered cautiously in patients with hypertension.

References

  1. (2002) "Product Information. Benadryl (diphenhydramine)." Parke-Davis
  2. (2001) "Product Information. Antivert (meclizine)." Roerig Division
  3. (2001) "Product Information. Marezine (cyclizine)." Glaxo Wellcome
  4. Valentin N, Staffeldt H, Kyst A (1984) "Effect of i.v. atropine on cardiac rhythm, heart rate, blood pressure and airway secretion during isoflurane anaesthesia." Acta Anaesthesiol Scand, 28, p. 621-4
  5. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
  6. (2001) "Product Information. Artane (trihexyphenidyl)." Lederle Laboratories
  7. (2002) "Product Information. Atropisol (atropine ophthalmic)." Ciba Vision Ophthalmics
View all 7 references
Minor

Anticholinergics (applies to hyoscyamine/methenamine) hyperthyroidism

Minor Potential Hazard, Low plausibility.

In general, agents with anticholinergic activity may exacerbate hyperthyroidism. Therapy with anticholinergics should be administered cautiously in patients with hyperthyroidism. Thyroid levels should be monitored if usage is prolonged.

References

  1. (2002) "Product Information. Dimetane (brompheniramine)." Wyeth-Ayerst Laboratories
  2. "Product Information. Chlor-Trimeton (chlorpheniramine)." Schering-Plough
  3. (2002) "Product Information. Periactin (cyproheptadine)." Merck & Co., Inc
  4. (2001) "Product Information. Tavist (clemastine)." Sandoz Pharmaceuticals Corporation
  5. (2001) "Product Information. Antivert (meclizine)." Roerig Division
  6. (2001) "Product Information. Optimine (azatadine)." Schering Corporation
  7. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
  8. (2001) "Product Information. Poly-Histine-D (pyrilamine)." Bock Pharmacal Company
View all 8 references
Minor

Antimuscarinics (applies to hyoscyamine/methenamine) diarrhea

Minor Potential Hazard, Moderate plausibility.

Diarrhea may be a symptom of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy. Antimuscarinic agents may further aggravate the diarrhea. Therefore, these drugs should be administered cautiously in patients with diarrhea.

References

  1. (1975) "Lomotil for diarrhea in children." Med Lett Drugs Ther, 17, p. 104
  2. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
Minor

Atropine-like agents (applies to hyoscyamine/methenamine) fever

Minor Potential Hazard, Low plausibility.

Atropine-like agents may increase the risk of hyperthermia in patients with fever by producing anhidrosis. Therapy with atropine-like agents should be administered cautiously in febrile patients.

References

  1. Stadnyk AN, Glezos JD (1983) "Drug-induced heat stroke." Can Med Assoc J, 128, p. 957-9
  2. Sarnquist F, Larson CP Jr (1973) "Drug-induced heat stroke." Anesthesiology, 39, p. 348-50
  3. Lee BS (1986) "Possibility of hyperpyrexia with antipsychotic and anticholinergic drugs." J Clin Psychiatry, 47, p. 571
  4. Forester D (1978) "Fatal drug-induced heat stroke." JACEP, 7, p. 243-4
  5. (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
  6. (2001) "Product Information. Cogentin (benztropine)." Merck & Co., Inc
View all 6 references

Hyoscyamine/methenamine drug interactions

There are 244 drug interactions with hyoscyamine / methenamine.

Hyoscyamine/methenamine alcohol/food interactions

There are 2 alcohol/food interactions with hyoscyamine / methenamine.


Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.