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Givosiran Disease Interactions

There is 1 disease interaction with givosiran.

Moderate

Givosiran (applies to givosiran) hepatic/renal

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Liver Disease

The effect of end-stage renal disease (eGFR <15 mL/min/1.73m2), and moderate to severe hepatic impairment on givosiran pharmacokinetics is unknown. Additionally, hepatic and renal toxicity was observed in up to 15% of patients treated with givosiran in clinical trials. Caution and regular monitoring is advised when using givosiran in patients with hepatic or renal impairment.

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Givosiran drug interactions

There are 239 drug interactions with givosiran.

Givosiran alcohol/food interactions

There is 1 alcohol/food interaction with givosiran.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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