Antizol Disease Interactions
There is 1 disease interaction with Antizol (fomepizole).
Fomepizole (applies to Antizol) hepatic/renal dysfunction
Moderate Potential Hazard, Low plausibility. Applicable conditions: Liver Disease
The pharmacokinetic disposition of fomepizole has not been determined in patients with hepatic and/or renal impairment. Fomepizole is extensively metabolized by the liver. Following multiple dosing, fomepizole induces its own metabolism and the rate of elimination is increased. About 1% to 3.5% of fomepizole is eliminated unchanged in the urine. Therapy with fomepizole should be administered cautiously in patients with compromised hepatic and/or renal function. Fomepizole is dialyzable and the frequency of dosing should be increased to every 4 hours during hemodialysis.
References (1)
- (2001) "Product Information. Antizol (fomepizole)." Jazz Pharmaceuticals
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Antizol drug interactions
There is 1 drug interaction with Antizol (fomepizole).
Antizol alcohol/food interactions
There is 1 alcohol/food interaction with Antizol (fomepizole).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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