Doxercalciferol Disease Interactions
There are 2 disease interactions with doxercalciferol:
Vitamin D analogs (applies to doxercalciferol) hypercalcemia
Major Potential Hazard, Moderate plausibility. Applicable conditions: Malabsorption Syndrome
Vitamin D analogs such as calciferol and ergocalciferol should not be given to patients with hypercalcemia, malabsorption syndrome, or evidence of vitamin D toxicity.
Vitamin D analogs (applies to doxercalciferol) hepatobiliary dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease, Biliary Obstruction
Vitamin D analogs are fat soluble and oral formulations require bile for adequate intestinal absorption. Hepatic and/or biliary dysfunction decrease the absorption of vitamin D analogs. Metabolites of vitamin D analogs are primarily excreted in bile and feces. Ergocalciferol, cholecalciferol, and dihydrotachysterol undergo hepatic hydroxylation during metabolic activation. Hepatic impairment can alter the metabolic and therapeutic activity of certain vitamin D analogs. Alternative vitamin D analogs such as calcifediol (requires renal activation) and calcitriol (active form) may be considered in patients with compromised hepatic function.
- "Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.
- "Product Information. Calciferol (ergocalciferol)." Schwarz Pharma, Mequon, WI.
- "Product Information. Calderol (calcifediol)." Organon, West Orange, NJ.
Doxercalciferol drug interactions
There are 76 drug interactions with doxercalciferol
More about doxercalciferol
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- Drug class: vitamins
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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