Pifeltro Disease Interactions
There are 2 disease interactions with Pifeltro (doravirine).
Doravirine (applies to Pifeltro) liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Doravirine has not been studied in patients with severe liver dysfunction (Child-Pugh C); caution is recommended. No dosage adjustment of doravirine is needed in patients with mild or moderate liver dysfunction (Child-Pugh A or B).
Doravirine (applies to Pifeltro) renal dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: peritoneal dialysis
Doravirine has not been adequately studied in patients with ESRD and has not been studied in patients receiving dialysis; caution is recommended. No dosage adjustment of doravirine is needed in patients with mild, moderate, or severe renal dysfunction.
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Pifeltro drug interactions
There are 189 drug interactions with Pifeltro (doravirine).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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