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Dolutegravir Disease Interactions

There are 3 disease interactions with dolutegravir:

Moderate

Dolutegravir (Includes Dolutegravir) ↔ Hemodialysis

Moderate Potential Hazard, Moderate plausibility

Applies to: hemodialysis

Dolutegravir has not been studied in patients on dialysis, so caution is recommended if used in these patients.

Moderate

Dolutegravir (Includes Dolutegravir) ↔ Hepatitis

Moderate Potential Hazard, Moderate plausibility

Applies to: Infectious Hepatitis

Patients with underlying hepatitis B or C may be at increased risk for worsening or development of transaminase elevations with the use of dolutegravir. In some cases there was hepatitis B reactivation particularly in a setting where anti- hepatitis treatment was withdrawn. Appropriate laboratory testing prior to initiating treatment and monitoring for hepatotoxicity during therapy is recommended in patients with underlying hepatitis B or C.

Moderate

Dolutegravir (Includes Dolutegravir) ↔ Liver Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

The effect of severe hepatic impairment (Child - Pugh C) on the pharmacokinetics of dolutegravir has not been studied, therefore dolutegravir is not recommended for use on these patients. No dosage adjustment is needed for patients with mild or moderate hepatic impairment.

dolutegravir drug Interactions

There are 250 drug interactions with dolutegravir

dolutegravir alcohol/food Interactions

There are 2 alcohol/food interactions with dolutegravir

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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