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Dolutegravir Disease Interactions

There are 3 disease interactions with dolutegravir:

Moderate

Dolutegravir (applies to dolutegravir) hemodialysis

Moderate Potential Hazard, Moderate plausibility.

Dolutegravir has not been studied in patients on dialysis, so caution is recommended if used in these patients.

Moderate

Dolutegravir (applies to dolutegravir) hepatitis

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Infectious Hepatitis

Patients with underlying hepatitis B or C may be at increased risk for worsening or development of transaminase elevations with the use of dolutegravir. In some cases there was hepatitis B reactivation particularly in a setting where anti- hepatitis treatment was withdrawn. Appropriate laboratory testing prior to initiating treatment and monitoring for hepatotoxicity during therapy is recommended in patients with underlying hepatitis B or C.

Moderate

Dolutegravir (applies to dolutegravir) liver impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The effect of severe hepatic impairment (Child - Pugh C) on the pharmacokinetics of dolutegravir has not been studied, therefore dolutegravir is not recommended for use on these patients. No dosage adjustment is needed for patients with mild or moderate hepatic impairment.

Dolutegravir drug interactions

There are 151 drug interactions with dolutegravir

Dolutegravir alcohol/food interactions

There are 2 alcohol/food interactions with dolutegravir

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer