Dolutegravir Disease Interactions
There are 3 disease interactions with dolutegravir:
Dolutegravir (Includes Dolutegravir) ↔ Hemodialysis
Moderate Potential Hazard, Moderate plausibility
Applies to: hemodialysis
Dolutegravir has not been studied in patients on dialysis, so caution is recommended if used in these patients.
Dolutegravir (Includes Dolutegravir) ↔ Hepatitis
Moderate Potential Hazard, Moderate plausibility
Applies to: Infectious Hepatitis
Patients with underlying hepatitis B or C may be at increased risk for worsening or development of transaminase elevations with the use of dolutegravir. In some cases there was hepatitis B reactivation particularly in a setting where anti- hepatitis treatment was withdrawn. Appropriate laboratory testing prior to initiating treatment and monitoring for hepatotoxicity during therapy is recommended in patients with underlying hepatitis B or C.
Dolutegravir (Includes Dolutegravir) ↔ Liver Impairment
Moderate Potential Hazard, Moderate plausibility
Applies to: Liver Disease
The effect of severe hepatic impairment (Child - Pugh C) on the pharmacokinetics of dolutegravir has not been studied, therefore dolutegravir is not recommended for use on these patients. No dosage adjustment is needed for patients with mild or moderate hepatic impairment.
dolutegravir drug Interactions
There are 250 drug interactions with dolutegravir
dolutegravir alcohol/food Interactions
There are 2 alcohol/food interactions with dolutegravir
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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