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Dichlorphenamide Disease Interactions

There are 7 disease interactions with dichlorphenamide:


Dichlorphenamide (Includes Dichlorphenamide) ↔ Acidosis

Severe Potential Hazard, Moderate plausibility

Applies to: Acidosis

The use of dichlorphenamide is contraindicated acidotic patiens (hyperchloremic or respiratory).


Dichlorphenamide (Includes Dichlorphenamide) ↔ Adrenocortical Insufficiency

Severe Potential Hazard, Moderate plausibility

Applies to: Adrenal Insufficiency

The use of dichlorphenamide is contraindicated in adrenocortical insufficiency.


Dichlorphenamide (Includes Dichlorphenamide) ↔ Dehydration

Severe Potential Hazard, Moderate plausibility

Applies to: Dehydration, Hypokalemia, Hyponatremia

The use of dichlorphenamide is contraindicated in patients with hyponatremia or hypokalemia, or in conditions in which serum levels of sodium or potassium are depressed.


Dichlorphenamide (Includes Dichlorphenamide) ↔ Hepatic Disease

Severe Potential Hazard, Moderate plausibility

Applies to: Liver Disease

The use of dichlorphenamide is contraindicated in hepatic insufficiency.


Dichlorphenamide (Includes Dichlorphenamide) ↔ Pulmonary Disease

Severe Potential Hazard, Moderate plausibility

Applies to: Chronic Obstructive Pulmonary Disease

Dichlorphenamide should not be used in patients with severe pulmonary obstruction who are unable to increase their alveolar ventilation as their acidosis may be increased.


Dichlorphenamide (Includes Dichlorphenamide) ↔ Renal Dysfunction

Severe Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

The use of dichlorphenamide is contraindicated in renal failure.


Carbonic Anhydrase Inhibitors (Includes Dichlorphenamide) ↔ Diabetes Mellitus

Moderate Potential Hazard, Low plausibility

Applies to: Diabetes Mellitus

Elevation of blood glucose, possibly caused by hypokalemia, and glycosuria have been reported rarely in diabetics receiving carbonic anhydrase inhibitors. Therapy with carbonic anhydrase inhibitors should be administered cautiously in patients with diabetes mellitus. Routine glucose monitoring is recommended during therapy.


  1. Siklos P, Henderson RG "Severe acidosis from acetazolamide in a diabetic patient." Curr Med Res Opin 6 (1979): 284-6
  2. Hannedouche T, Lazaro M, Delgado AG, Boitard C, Lacour B, Grunfeld JP "Feedback-mediated reduction in glomerular filtration during acetazolamide infusion in insulin-dependent diabetic patients." Clin Sci 81 (1991): 457-64
  3. "Product Information. Diamox (acetazolamide)." Lederle Laboratories, Wayne, NJ.

dichlorphenamide drug Interactions

There are 355 drug interactions with dichlorphenamide

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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