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Choloxin (dextrothyroxine sodium) Disease Interactions

There are 5 disease interactions with Choloxin (dextrothyroxine sodium):

Major

Dextrothyroxine (Includes Choloxin) ↔ Cardiovascular Disease

Severe Potential Hazard, High plausibility

Applies to: Hypertension, Heart Disease, Obesity, History (Familial) - Ischemic Heart Disease

The use of dextrothyroxine sodium is contraindicated in euthyroid patients with one or more of the following conditions: hypertension (other than mild, labile systolic hypertension); known or suspected organic heart disease, especially coronary heart disease; a history of myocardial infarction; cardiac arrhythmias or a demonstrated propensity for arrhythmias; tachycardia; rheumatic heart disease; a history of congestive heart failure; or decompensated or borderline compensated cardiac status. Dextrothyroxine sodium may cause severe cardiotoxicity related to its thyroid hormone activity, occasionally even in patients without apparent underlying cardiac abnormalities. In a large study involving men who had had a myocardial infarction, treatment with dextrothyroxine sodium was associated with a trend toward increased mortality relative to placebo. Therapy with dextrothyroxine sodium should be considered and administered cautiously in patients with risk factors for coronary artery disease, including obesity, a history of smoking, and/or a family history of premature coronary disease.

References

  1. "Product Information. Choloxin (dextrothyroxine sodium)." Knoll Pharmaceutical Company, Mount Olive, NJ.
Major

Dextrothyroxine (Includes Choloxin) ↔ Hyperthyroidism

Severe Potential Hazard, High plausibility

Applies to: Hyperthyroidism

The use of dextrothyroxine sodium is contraindicated in patients with hyperthyroidism or a history of iodism. Dextrothyroxine sodium possesses thyroid hormone activity and may exacerbate these conditions.

References

  1. "Product Information. Choloxin (dextrothyroxine sodium)." Knoll Pharmaceutical Company, Mount Olive, NJ.
Major

Dextrothyroxine (Includes Choloxin) ↔ Liver Disease

Severe Potential Hazard, High plausibility

Applies to: Liver Disease

The use of dextrothyroxine sodium is contraindicated in patients with advanced liver disease. The site of action of dextrothyroxine sodium is in the liver, where it stimulates the catabolism and excretion of cholesterol and its degradation products via the biliary route into the feces. Patients with severe hepatic impairment may not tolerate these effects.

References

  1. "Product Information. Choloxin (dextrothyroxine sodium)." Knoll Pharmaceutical Company, Mount Olive, NJ.
Major

Dextrothyroxine (Includes Choloxin) ↔ Renal Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Renal Dysfunction

The use of dextrothyroxine sodium is contraindicated in patients with advanced kidney disease. The clearance of dextrothyroxine sodium may be reduced when renal function is impaired. Therapy with dextrothyroxine sodium should be administered cautiously in patients with mild to moderate degrees of renal impairment. A more gradual dosage titration may be required to prevent toxicity.

References

  1. "Product Information. Choloxin (dextrothyroxine sodium)." Knoll Pharmaceutical Company, Mount Olive, NJ.
Moderate

Dextrothyroxine (Includes Choloxin) ↔ Hyperglycemia

Moderate Potential Hazard, Moderate plausibility

Applies to: Diabetes Mellitus

Dextrothyroxine sodium can elevate serum glucose levels and decrease glucose tolerance in diabetic patients. Patients with diabetes mellitus should be monitored more closely during dextrothyroxine therapy, and adjustments made accordingly in their antidiabetic regimen. If an increase in insulin and/or oral hypoglycemic dosage is required, clinicians should be aware that readjustments may likely be necessary whenever dextrothyroxine therapy is withdrawn.

References

  1. "Product Information. Choloxin (dextrothyroxine sodium)." Knoll Pharmaceutical Company, Mount Olive, NJ.

Choloxin (dextrothyroxine sodium) drug Interactions

There are 16 drug interactions with Choloxin (dextrothyroxine sodium)

Choloxin (dextrothyroxine sodium) alcohol/food Interactions

There are 2 alcohol/food interactions with Choloxin (dextrothyroxine sodium)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2016 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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