Moderna COVID-19 Vaccine Disease Interactions
There are 3 disease interactions with Moderna COVID-19 Vaccine (COVID-19 mRNA (Moderna) vaccine).
COVID-19 vaccine, mRNA (applies to Moderna COVID-19 Vaccine) immunodeficiency
Moderate Potential Hazard, Moderate plausibility.
Immunocompromised individuals, including those receiving immunosuppressive therapy, may have a diminished immune response to the messenger RNA COVID-19 vaccine. The US CDC has published considerations related to COVID-19 vaccination for individuals who are moderately to severely immunocompromised (https://www.cdc.gov/covid/hcp/vaccine-considerations/).
COVID-19 vaccine, mRNA (applies to Moderna COVID-19 Vaccine) syncope
Moderate Potential Hazard, Moderate plausibility.
Syncope may occur in association with administration of injectable vaccines, including the messenger RNA COVID-19 vaccine. Procedures should be in place to avoid injury from fainting, especially for patients who have previously fainted in association with an injection.
Vaccines (applies to Moderna COVID-19 Vaccine) IM injection
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Thrombocytopathy, Thrombocytopenia, Coagulation Defect
In patients with thrombocytopenia or coagulation disorders, IM injections may produce bleeding and hematomas. Patients with a platelet count less than 50,000/mm3 are at an increased risk. Caution is advised if the vaccine (e.g., plague vaccine; hepatitis A and B vaccines; aluminum-adsorbed DTaP, DTP, DT, or Td) must be administered IM. The risk of bleeding may be minimized by vaccination immediately after the administration of replacement factor, use of a 23-gauge (or smaller) needle, and immediate application of direct pressure to the vaccination site for at least 2 minutes.
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Moderna COVID-19 Vaccine drug interactions
There are 351 drug interactions with Moderna COVID-19 Vaccine (COVID-19 mRNA (Moderna) vaccine).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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