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Milophene Disease Interactions

There are 5 disease interactions with Milophene (clomiphene).

Major

Clomiphene (applies to Milophene) abnormal uterine bleeding

Major Potential Hazard, High plausibility.

The use of clomiphene is contraindicated in patients with undiagnosed, abnormal genital bleeding. Patients should be evaluated to ensure that neoplastic lesions are not present.

References

  1. (2022) "Product Information. ClomiPHENE Citrate (clomiPHENE)." Teva Pharmaceuticals USA
Major

Clomiphene (applies to Milophene) hepatic dysfunction

Major Potential Hazard, High plausibility. Applicable conditions: Liver Disease

The use of clomiphene is contraindicated in patients with liver disease or history of hepatic dysfunction.. Clomiphene undergoes enterohepatic circulation and is metabolized by the liver. The serum concentration of clomiphene may be increased and the half-life prolonged in patients with compromised hepatic function.

References

  1. (2022) "Product Information. ClomiPHENE Citrate (clomiPHENE)." Teva Pharmaceuticals USA
Major

Clomiphene (applies to Milophene) pituitary activity

Major Potential Hazard, High plausibility. Applicable conditions: Pituitary Tumor, Brain/Intracranial Tumor, Thyroid Disease, Adrenal Insufficiency

The use of clomiphene is contraindicated in patients with uncontrolled thyroid or adrenal dysfunction or an organic intracranial lesion such as a pituitary tumor. Clomiphene interacts with estrogen receptors in various tissues, including the pituitary, the response of which is an increase in the release of pituitary gonadotropins.

References

  1. (2022) "Product Information. ClomiPHENE Citrate (clomiPHENE)." Teva Pharmaceuticals USA
Major

Clomiphene (applies to Milophene) uncontrolled adrenal dysfunction

Major Potential Hazard, High plausibility. Applicable conditions: Adrenal Insufficiency, Hyperadrenocorticism, Adrenal Tumor, Hyperaldosteronism

The use of clomiphene is contraindicated in patients with uncontrolled adrenal function. Alterations of adrenal function can impede pregnancy. Clomiphene therapy can result in alteration in steroid synthesis and/or fluid regulation.

References

  1. (2022) "Product Information. ClomiPHENE Citrate (clomiPHENE)." Teva Pharmaceuticals USA
Moderate

Clomiphene (applies to Milophene) hyperlipidemia

Moderate Potential Hazard, Moderate plausibility.

Cases of hypertriglyceridemia have been reported in patients receiving clomiphene treatment. Preexisting or family history of hyperlipidemia and use of higher than recommended dose and/or longer duration of treatment with clomiphene citrate are associated with a risk of hypertriglyceridemia. Periodic monitoring of plasma triglycerides is recommended in patients with preexisting or family history of hyperlipidemia. Pretreatment screening of triglyceride levels is recommended in patients initiating clomiphene citrate therapy.

References

  1. (2022) "Product Information. ClomiPHENE Citrate (clomiPHENE)." Teva Pharmaceuticals USA

Milophene drug interactions

There are 4 drug interactions with Milophene (clomiphene).

Milophene alcohol/food interactions

There is 1 alcohol/food interaction with Milophene (clomiphene).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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