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Citric acid / glucono-delta-lactone / magnesium carbonate topical Disease Interactions

There are 2 disease interactions with citric acid / glucono-delta-lactone / magnesium carbonate topical:


Glucono-delta-lactone (Includes citric acid/glucono-delta-lactone/magnesium carbonate topical) ↔ urinary tract infection

Severe Potential Hazard, High plausibility. Applies to: Urinary Tract Infection, Urinary Tract Obstruction

The use of glucono-delta-lactone is contraindicated in the presence of demonstrable urinary tract extravasation and also should be stopped immediately in the presence of a urinary tract infection (UTI). Glucono-delta-lactone is part of an irrigant (citric acid, glucose-delta-lactone, magnesium carbonate) designed to dissolve struvite renal stones, which contain urea- splitting bacteria. Dissolution of bacteria- containing stones in the presence of a UTI may result in sepsis and death. Urine should be sterile prior to initiating therapy and antibiotics administered throughout the course of dissolution therapy.


  1. "Product Information. Renacidin (glucono-delta-lactone)." Guardian Labs, div United-Guardian Inc, Hauppage, NY.

Magnesium salts (Includes citric acid/glucono-delta-lactone/magnesium carbonate topical) ↔ renal dysfunction

Severe Potential Hazard, High plausibility. Applies to: Renal Dysfunction

Magnesium is eliminated by the kidney. The serum concentration of magnesium is increased in patients with renal impairment. Magnesium toxicity includes CNS depression, muscular paralysis, respiratory depression, hypotension and prolonged cardiac conduction time. Disappearance of the patellar reflex is a useful clinical sign of magnesium intoxication. Therapy with magnesium should be administered cautiously and dosages should be modified in patients with compromised renal function. Clinical monitoring of serum magnesium levels is recommended.


  1. "Product Information. Mag-Ox 400 (magnesium oxide)." Blaine, Erlanger, KY.
  2. "Product Information. Losospan (magaldrate)." Whitehall-Robbins, Madison, NJ.
  3. "Product Information. Uro-Mag (magnesium oxide)." Blaine, Erlanger, KY.
  4. "Product Information. Slow-Mag (magnesium chloride)." Searle, Skokie, IL.
  5. "Product Information. Magonate (magnesium gluconate)." Fleming and Company, Fenton, MO.
View all 5 references

Citric acid / glucono-delta-lactone / magnesium carbonate topical drug interactions

There are 370 drug interactions with citric acid / glucono-delta-lactone / magnesium carbonate topical

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.