Citric acid / glucono-delta-lactone / magnesium carbonate topical Disease Interactions
There are 2 disease interactions with citric acid / glucono-delta-lactone / magnesium carbonate topical:
Glucono-delta-lactone (Includes citric acid/glucono-delta-lactone/magnesium carbonate topical) ↔ urinary tract infection
Severe Potential Hazard, High plausibility. Applies to: Urinary Tract Infection, Urinary Tract Obstruction
The use of glucono-delta-lactone is contraindicated in the presence of demonstrable urinary tract extravasation and also should be stopped immediately in the presence of a urinary tract infection (UTI). Glucono-delta-lactone is part of an irrigant (citric acid, glucose-delta-lactone, magnesium carbonate) designed to dissolve struvite renal stones, which contain urea- splitting bacteria. Dissolution of bacteria- containing stones in the presence of a UTI may result in sepsis and death. Urine should be sterile prior to initiating therapy and antibiotics administered throughout the course of dissolution therapy.
- "Product Information. Renacidin (glucono-delta-lactone)." Guardian Labs, div United-Guardian Inc, Hauppage, NY.
Magnesium salts (Includes citric acid/glucono-delta-lactone/magnesium carbonate topical) ↔ renal dysfunction
Severe Potential Hazard, High plausibility. Applies to: Renal Dysfunction
Magnesium is eliminated by the kidney. The serum concentration of magnesium is increased in patients with renal impairment. Magnesium toxicity includes CNS depression, muscular paralysis, respiratory depression, hypotension and prolonged cardiac conduction time. Disappearance of the patellar reflex is a useful clinical sign of magnesium intoxication. Therapy with magnesium should be administered cautiously and dosages should be modified in patients with compromised renal function. Clinical monitoring of serum magnesium levels is recommended.
- "Product Information. Mag-Ox 400 (magnesium oxide)." Blaine, Erlanger, KY.
- "Product Information. Losospan (magaldrate)." Whitehall-Robbins, Madison, NJ.
- "Product Information. Uro-Mag (magnesium oxide)." Blaine, Erlanger, KY.
- "Product Information. Slow-Mag (magnesium chloride)." Searle, Skokie, IL.
- "Product Information. Magonate (magnesium gluconate)." Fleming and Company, Fenton, MO.
Citric acid / glucono-delta-lactone / magnesium carbonate topical drug interactions
There are 370 drug interactions with citric acid / glucono-delta-lactone / magnesium carbonate topical
More about citric acid/glucono-delta-lactone/magnesium carbonate topical
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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