Burosumab Disease Interactions
There are 3 disease interactions with burosumab.
Burosumab (applies to burosumab) hyperphosphatemia
Major Potential Hazard, Moderate plausibility. Applicable conditions: Phosphate Imbalance
Do not initiate burosumab-twza treatment if serum phosphorus is within or above the normal range for age. Increases in serum phosphorus to above the upper limit of normal may be associated with an increased risk of nephrocalcinosis. It is recommended to obtain baseline fasting serum phosphorus levels and to monitor fasting serum phosphorus levels. Dose interruption and/or dose reduction may be required based on a patient's serum phosphorus levels.
Burosumab (applies to burosumab) renal impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Burosumab-twza is contraindicated in patients with severe renal impairment or end stage renal disease because these conditions are associated with abnormal mineral metabolism. The effect of renal impairment on the pharmacokinetics of burosumab-twza is unknown.
Burosumab (applies to burosumab) RLS
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Neurologic Disorder
The use of burosumab-twza may cause new onset of restless leg syndrome (RLS) or worsen RLS severity. Care should be exercised when using this agent in patients with existing RLS diagnosis.
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Burosumab drug interactions
There are 17 drug interactions with burosumab.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Drisdol
Drisdol is used for familial hypophosphatemia, hypocalcemia, hypoparathyroidism, hypophosphatemia ...
Crysvita
Crysvita is used for familial hypophosphatemia, osteomalacia, X-Linked Hypophosphatemia
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Calcidol
Calcidol is used for familial hypophosphatemia, hypocalcemia, hypoparathyroidism, hypophosphatemia ...
Calcium lactate
Calcium lactate systemic is used for hypocalcemia, hypoparathyroidism, osteomalacia, osteoporosis ...
Ergocalciferol
Ergocalciferol systemic is used for familial hypophosphatemia, hypocalcemia, hypoparathyroidism ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.