Prostin VR Pediatric Disease Interactions
There are 3 disease interactions with Prostin VR Pediatric (alprostadil).
Alprostadil (applies to Prostin VR Pediatric) respiratory function
Major Potential Hazard, Moderate plausibility. Applicable conditions: Sepsis, Pulmonary Impairment
Alprostadil injection should not be used in neonates with respiratory distress syndrome. Apnea is experienced by about 10 to 12% of neonates with congenital heart defects treated with alprostadil injection. Respiratory status should be monitored throughout treatment, and alprostadil injection should be used where ventilatory assistance is immediately available.
Alprostadil (applies to Prostin VR Pediatric) bleeding
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Bleeding Associated with Coagulation Defect
Alprostadil inhibits platelet aggregation. Caution is recommended when using alprostadil injection in neonates with bleeding tendencies.
Alprostadil (applies to Prostin VR Pediatric) hypotension
Moderate Potential Hazard, Moderate plausibility.
Increased peripheral blood levels of prostaglandin E1 (PGE1) and its metabolites can lead to hypotension and/or dizziness. Intracavernous injections of alprostadil can lead to increased blood levels of PGE1. Therapy with alprostadil should be administered cautiously in patients with hypotension.
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Prostin VR Pediatric drug interactions
There are 44 drug interactions with Prostin VR Pediatric (alprostadil).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.