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Prostin VR Pediatric (alprostadil) Disease Interactions

There are 2 disease interactions with Prostin VR Pediatric (alprostadil):


Alprostadil (Includes Prostin VR Pediatric) ↔ respiratory function

Severe Potential Hazard, Moderate plausibility. Applies to: Sepsis, Pulmonary Impairment

Alprostadil injection should not be used in neonates with respiratory distress syndrome. Apnea is experienced by about 10 to 12% of neonates with congenital heart defects treated with alprostadil injection. Respiratory status should be monitored throughout treatment, and alprostadil injection should be used where ventilatory assistance is immediately available.


Alprostadil (Includes Prostin VR Pediatric) ↔ bleeding

Moderate Potential Hazard, Moderate plausibility. Applies to: Bleeding Associated with Coagulation Defect

Alprostadil inhibits platelet aggregation. Caution is recommended when using alprostadil injection in neonates with bleeding tendencies.

Prostin VR Pediatric (alprostadil) drug interactions

There are 39 drug interactions with Prostin VR Pediatric (alprostadil)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.