Lumizyme (alglucosidase alfa) Disease Interactions
There is 1 disease interaction with Lumizyme (alglucosidase alfa):
Lysosomal Enzymes (Includes Lumizyme) ↔ Hypersensitivity
Severe Potential Hazard, Moderate plausibility
Applies to: Pulmonary Impairment, Heart Disease
Patients with acute underlying respiratory illness or compromised cardiac and/or respiratory function may be at risk of serious exacerbation of their cardiac or respiratory symptoms due to hypersensitivity reactions during enzyme replacement therapy. Evaluation of cardiac function and airway patency should be considered before initiation of treatment. Appropriate medical support and monitoring measures should be readily available during enzyme replacement therapy, and some patients may require prolonged observation times that should be individualized based on the needs of the patient. Consider the risks and benefits of re-administering these agents following a severe reaction. Monitor patients, with appropriate resuscitation measures available, if the decision is made to re-administer the product.
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
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