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Rubidium rb 82 (Intravenous)

roo-BID-e-um KLOR-ide Rb 82

Intravenous route(Solution)

Unintended radiation exposure occurs when the levels of Sr-82 or Sr-85 in the rubidium Rb 82 chloride injection exceed specified limits. Perform generator eluate tests recording each generator eluate volume, including waste and test volumes and keep a record of the cumulative eluate volume. Determine Rb-82, Sr-82, Sr-85 in the generator eluate once a day, prior to any drug administrations, and at additional daily tests after detection of an alert limit. Alert limits are: 14 L for the generator’s cumulative eluate volume, an eluate Sr-82 level of 0.002 μCi/ mCi Rb-82, or an eluate Sr-85 level of 0.02 Sr-85 μCi/ mCi Rb-82. Perform the additional daily tests at time points determined by the day’s elution volume; tests are performed every 750 mL. Stop use of a generator at an expiration limit of 17 L for the generator’s cumulative eluate volume, 42 days post generator calibration date, an eluate Sr-82 level of 0.01 μCi /mCi Rb-82, or an eluate Sr-85 level of 0.1 μCi /mCi Rb-82 .

Medically reviewed on Nov 10, 2018

Commonly used brand name(s)

In the U.S.

  • Cardiogen-82 Generator

Available Dosage Forms:

  • Kit

Therapeutic Class: Diagnostic Agent, Radiopharmaceutical Imaging

Uses For rubidium rb 82

Rubidium Rb 82 injection is used in adults to help diagnose heart disease. It is used in a procedure called a positron emission tomography (PET) scan to help your doctor see an image of your heart. Rubidium rb 82 shows how much blood is getting to your heart muscle when you are resting or exercising (stressed). Rubidium Rb 82 belongs to the group of medicines called radiopharmaceuticals (radioactive agents).

Rubidium rb 82 will be used only by or under the direct supervision of your doctor.

Before Using rubidium rb 82

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For rubidium rb 82, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to rubidium rb 82 or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of rubidium Rb 82 injection in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rubidium Rb 82 injection in the elderly. However, elderly patients are more likely to have age-related heart problems, which may require caution in patients receiving rubidium Rb 82 injection.


Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of rubidium rb 82. Make sure you tell your doctor if you have any other medical problems, especially:

  • Congestive heart failure—Use with caution. May cause side effects to become worse.

Proper Use of rubidium rb 82

A doctor or other trained health professional will give you rubidium rb 82. Rubidium rb 82 is given through a needle placed in one of your veins just before you have a PET scan.

You will need to urinate right away and as often as possible for at least one hour after the PET scan.

Precautions While Using rubidium rb 82

It is very important that your doctor check your progress very closely while you are receiving rubidium rb 82. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

You might receive a medicine to make your heart beat faster. This is called a pharmacologic stress test. It is used together with the PET scan to show how well your heart muscle works when it is stressed. If you have questions about this test, talk to your doctor.

While receiving rubidium rb 82, you will be exposed to radiation. If you have any questions about this, talk to your doctor.

Rubidium rb 82 Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

More about rubidium chloride rb-82

Consumer resources

Other brands: Cardiogen-82

Professional resources

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