Rubidium Chloride Rb-82 Dosage

Usual Adult Dose for Positron Emission Tomography Imaging

While using the CardioGen-82 Model 510 Infusion System:
Rest or stress imaging: 1,480 MBq (40 mCi), with a range of 1,110 MBq to 2,220 MBq (30 mCi to 60 mCi) intravenously through a catheter inserted into a large peripheral vein at a rate of 50 mL/minute
Maximum dose: 2,220 MBq (60 mCi) or a maximum volume of 100 mL per rest or stress component of a procedure

While using the CardioGen-82 Model 1700 Infusion System:
Rest or stress imaging: 10 MBq/kg to 30 MBq/kg (0.27 mCi/kg to 0.81 mCi/kg) intravenously through a catheter inserted into a large peripheral vein at a rate of 20 mL/minute or 50 mL/minute
Maximum dose: 2,220 MBq (60 mCi) or a maximum volume of 100 mL per rest or stress component of a procedure

Comments:

• Adhere to aseptic techniques during all drug handling and administration.
• Confirm the use of the appropriate generator system when following the protocols for dosing, elution, and eluate testing.
• Use only additive-free 0.9% sodium chloride solution to elute this diagnostic agent.
• Use the lowest dose necessary.
• Administer two single doses to complete rest and stress myocardial perfusion imaging (MPI).
• Advise patients to void as soon as possible after administration and as often as possible thereafter for at least one hour after the completion of the PET scan.

Use: For positron emission tomography (PET) myocardial perfusion imaging (MPI) under rest or pharmacologic stress in adult patients with known or suspected coronary artery disease (CAD).

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

US BOXED WARNINGS:

• The use of an incorrect eluent can result in high Strontium (Sr) 82 and Sr 85 breakthrough levels.

Recommendations:

• Use only additive-free 0.9% sodium chloride solution to elute this diagnostic agent.
• If an incorrect eluent is used: immediately stop infusion, evaluate dose of radiation absorbed by the patient, monitor effects of radiation on critical organs such as bone marrow, and permanently discontinue using the affected generator.

• Excess radiation exposure occurs when the levels of Sr 82 or Sr 85 in this drug's injection exceeds limits.

Recommendations:

• Record eluate volume, including waste and test volumes.
• Closely follow generator eluate testing protocol.
• Discontinue using the generator if it reaches any of its expiration limits.

CONTRAINDICATIONS:

• None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration Advice:

• The manufacturer product information should be consulted.

Storage requirements:

• Store the generator at 20C to 25C (68F to 77F).
• Receipt, transfer, possession, storage, disposal, or use of this product is subject to the radioactive material regulations and licensing requirements of the U.S. Nuclear Regulatory Commission (NRC), Agreement States or Licensing States as appropriate.
• Do not dispose of the generator in regular refuse systems.
• For questions about the disposal of the CardioGen-82 generator, contact Bracco Diagnostics Inc. at 1-800-447-6883, option 3.

Reconstitution/preparation techniques:

• Adhere to aseptic techniques during all drug handling and administration.
• Confirm the use of the appropriate generator system when following the protocols for dosing, elution, and eluate testing.
• Use only additive-free 0.9% sodium chloride solution to elute this diagnostic agent.
• The manufacturer product information should be consulted.

Patient advice:

• Advise patients to void as soon as possible after administration and as often as possible thereafter for at least one hour after the completion of the PET scan.
• Advise a pregnant woman of potential risks to a developing fetus.
• Advise a lactating woman to minimize exposure of Rb 82 through breast by temporarily discontinue breastfeeding when this drug is administered and for at least one hour afterwards.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer