peramivir (Intravenous route)
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Pharmacologic Class: Neuraminidase Inhibitor, Influenza A&B Virus
Uses For peramivir
Peramivir injection is used to treat acute uncomplicated influenza in patients who have flu symptoms (eg, weakness, headache, fever, cough, runny or stuffy nose, sore throat) for no more than 2 days. Peramivir belongs to the family of medicines called antivirals, which are used to treat infections caused by viruses.
peramivir is to be given only by or under the direct supervision of your doctor.
Before Using peramivir
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For peramivir, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to peramivir or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of peramivir injection in children 2 years of age and older. Safety and efficacy have not been established in children younger than 2 years of age.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of peramivir injection in the elderly.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving peramivir, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using peramivir with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Influenza Virus Vaccine, Live
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of peramivir. Make sure you tell your doctor if you have any other medical problems, especially:
- Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper Use of peramivir
A nurse or other trained health professional will give you peramivir in a hospital. It is given through a needle placed into one of your veins. The medicine must be injected slowly, so your IV tube will need to stay in place for 15 to 30 minutes.
peramivir should be given as soon as possible after flu symptoms start or after you are exposed to the flu (within the first 2 days).
Precautions While Using peramivir
Your doctor will check your or your child's progress closely while you are receiving peramivir. This is to make sure that the infection is cleared up completely.
Serious skin reactions can occur with peramivir. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are receiving peramivir.
peramivir may cause some people to be confused or display other abnormal behaviors. Tell your doctor right away if you have hallucinations (seeing, hearing, or feeling things that are not there) or unusual excitement, nervousness, or restlessness after receiving peramivir.
Make sure your doctor knows if you plan to get the live flu vaccine nasal spray before you start receiving peramivir. You should not use the vaccine within 2 weeks before or 48 hours after receiving peramivir.
If your symptoms do not improve after you receive peramivir, or if they become worse, check with your doctor.
peramivir Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:Less common
- Cloudy urine
- Blistering, peeling, or loosening of the skin
- confusion as to time, place, or person
- difficulty swallowing
- fast heartbeat
- hives, itching, skin rash
- holding false beliefs that cannot be changed by fact
- joint or muscle pain
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red, irritated eyes
- red skin lesions, often with a purple center
- seeing, hearing, or feeling things that are not there
- sore throat
- sores, ulcers, or white spots in the mouth or on the lips
- tightness in the chest
- unusual excitement, nervousness, or restlessness
- unusual tiredness or weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common
- Blurred vision
- difficulty having a bowel movement
- pounding in the ears
- redness of the eardrum
- slow or fast heartbeat
- trouble sleeping
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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More about peramivir
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Español
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- Drug class: neuraminidase inhibitors
Other brands: Rapivab