Generic name: fat emulsion (intravenous route) [ fat-e-MULL-shun ]
Drug class: Intravenous nutritional products
Medically reviewed by Drugs.com. Last updated on Jan 20, 2022.
Deaths in preterm infants after infusion of intravenous fat emulsion have been reported in the medical literature. Autopsy findings included intravascular fat accumulation in the lungs. Treatment of premature and low birth weight infants with intravenous fat emulsion must be based upon careful benefit-risk assessment. Strict adherence to the recommended total daily dose is mandatory; hourly infusion rate should be as slow as possible in each case and the total fat should not in any case exceed 1 g fat/kg in four hours. Premature and small for gestational age infants have poor clearance of intravenous fat emulsion and increased free fatty acid plasma levels following fat emulsion infusion; therefore, serious consideration must be given to administration of less than the maximum recommended doses in these patients in order to decrease the likelihood of intravenous fat overload. The infant’s ability to eliminate the infused fat from the circulation must be carefully monitored (such as serum triglycerides and/or plasma free fatty acid levels). The lipemia must clear between daily infusions .
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Parenteral Lipids
Uses for Liposyn
Fat emulsions are used for nutritional support in patients who are unable to get enough fat in their diet, usually because of certain illnesses (eg, parenteral nutrition-associated cholestasis) or recent surgery. Fats are used by the body for energy and to form substances needed for normal body functions.
This medicine is to be given only by or under the direct supervision of your doctor.
Before using Liposyn
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Omegaven® in children. However, children are more likely to have unwanted effects (eg, agitation, slow heartbeat, vomiting). Safety and efficacy have been established in children.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Intralipid® in children.
Appropriate studies have not been performed on the relationship of age to the effects of Omegaven® in the elderly.
No information is available on the relationship of age to the effects of Intralipid® in geriatric patients.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Allergy to egg, fish, or soybean proteins, olive oil, or safflower oil or
- Bleeding disorder, severe or
- Hyperlipidemia (high triglycerides or fats in the blood), severe or
- Lipid metabolism disorders, severe—Should not be used in patients with these conditions.
- Blood problems or
- Diabetes or
- Liver disease or
- Lung or breathing problems or
- Pancreatitis (inflammation or swelling of the pancreas), history of—Use with caution. May make these conditions worse.
- Electrolyte imbalance or
- Fluid disorder or
- Metabolic disorders, severe—Should be corrected first before receiving this medicine.
- Hypertriglyceridemia (high triglycerides or fats in the blood)—Use with caution. May increase risk of pancreas problems.
- Infection—May decrease your body's ability to fight infections.
- Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
- Undernourished patients, severely—May cause refeeding syndrome. Monitor and increase nutrient intake slowly for the patients.
Proper use of Liposyn
This section provides information on the proper use of a number of products that contain fat emulsion. It may not be specific to Liposyn. Please read with care.
A nurse or other trained health professional will give you or your child this medicine in a medical facility. It may be used alone or added to your or your baby's TPN bag. It is given through a needle placed into one of your veins.
Precautions while using Liposyn
It is very important that your doctor check your or your child's progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly. Blood and urine tests will be needed to check for unwanted effects.
This medicine may cause serious allergic reactions. Check with your doctor right away if you have bluish color of fingernails, lips, skin, palms, or nail beds, blurred vision, chest tightness, confusion, cough, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, pounding, or irregular heartbeat or pulse, nausea, sweating, trouble breathing, unusual tiredness or weakness, or vomiting.
This medicine may increase your risk of developing infections. Avoid being near people who are sick or have infections while you or your child are receiving this medicine. Wash your hands often. Tell your doctor if you have any kind of infection before you start receiving this medicine. Also tell your doctor if you have ever had an infection that would not go away or an infection that kept coming back.
Call your doctor right away if you or your child start to have a cough that will not go away, weight loss, night sweats, fever, chills, or flu-like symptoms, such as a runny or stuffy nose, headache, blurred vision, or feeling generally ill. These may be signs that you have an infection.
This medicine may cause a rare condition called fat overload syndrome. Tell your doctor right away if you or your child have a fever, chills, cough, sore throat, right upper abdominal or stomach pain and fullness, or unusual bleeding, bruising, or weakness.
Call your doctor if you or your child have redness, swelling, pain, or infection at the injection site.
This medicine may cause electrolyte imbalance, fluid overload, and aluminum toxicity (too much aluminum in the blood), which may damage the brain and can be life-threatening. Talk to your doctor if you have concerns.
Before you have any medical tests, tell the medical doctor in charge that you are receiving this medicine. The results of some tests may be affected by this medicine.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Liposyn side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- Accumulation of pus
- black, tarry stools
- bladder pain
- bloody or cloudy urine
- bluish lips or skin
- chest pain or discomfort
- difficult, burning, or painful urination
- excessive muscle tone
- frequent urge to urinate
- general feeling of discomfort or illness
- joint pain
- lightheadedness, dizziness, or fainting
- loss of appetite
- lower back or side pain
- muscle aches, pains, stiffness, tension, or tightness
- pale skin
- runny nose
- slow or irregular heartbeat
- sore throat
- swollen, red, tender area of infection
- trouble sleeping
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
- unusual tiredness or weakness
- Back pain
- fast heartbeat
Incidence not known
- Bleeding gums
- changes in skin color
- changes in urination
- coughing up blood
- difficulty in breathing or swallowing
- fruit-like breath odor
- increased menstrual flow or vaginal bleeding
- increased thirst
- muscle cramps
- numbness, tingling, pain, or weakness in the hands or feet
- prolonged bleeding from cuts
- red or dark brown urine
- red or black, tarry stools
- stomach pain
- swelling and redness in the lower leg
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- redness of the skin
- redness, swelling, or pain at the injection site
- Itchy skin
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
More about fat emulsion
- Side effects
- Drug interactions
- Dosage information
- During pregnancy
- Drug class: intravenous nutritional products
- Advanced Reading
- Fat emulsion, fish oil, and soybean oil Intravenous (Advanced Reading)
- Fat Emulsion (Fish Oil Based)
- Fat Emulsion (Fish Oil and Plant Based)
- Fat Emulsion (Plant Based)
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.