fat emulsion (Intravenous route)
Deaths due to intravascular fat accumulation in the lungs in preterm infants after infusion of intravenous fat emulsion have been reported in the medical literature . Autopsy findings included intravascular fat accumulation in the lungs. Preterm infants and low-birth-weight infants have poor clearance of intravenous lipid emulsion and increased free fatty acid plasma levels following lipid emulsion infusion . Use caution when treating premature and low birth weight infants with intravenous fat emulsion and strictly adhere to the recommended total daily dose and hourly infusion rates. Hourly infusion rate should be as slow as possible in each case and fat should not in any case exceed 1 g fat/kg in four hours. Carefully monitor serum triglycerides and/or plasma free fatty acid levels in these patients . .
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Parenteral Lipids
Uses For fat emulsion
Fat emulsions are used as dietary supplements for patients who are unable to get enough fat in their diet, usually because of certain illnesses or recent surgery. Fats are used by the body for energy and to form substances needed for normal body functions.
fat emulsion is available only with your doctor's prescription.
Before Using fat emulsion
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For fat emulsion, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to fat emulsion or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Use of Clinolipid® is not indicated in children. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Clinolipid® in the elderly.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of fat emulsion. Make sure you tell your doctor if you have any other medical problems, especially:
- Allergy to eggs, olive oil, soybean proteins, or safflower oil or
- Hyperlipidemia (high triglycerides or fats in the blood), severe or
- Lipid metabolism disorders, severe—Should not be used in patients with these conditions.
- Blood problems or
- Diabetes or
- Gallbladder problems (gallstones) or
- Heart failure or
- Liver disease or
- Pancreatitis (inflammation or swelling of the pancreas), history of or
- Pulmonary edema (fluid in the lungs)—Use with caution. May make these conditions worse.
- Electrolyte imbalance or
- Metabolic disorders, severe—Should be corrected first before using fat emulsion.
- Hypertriglyceridemia (high triglycerides or fats in the blood)—Use with caution. May increase risk of pancreas problems.
- Infection—May decrease your body's ability to fight infections.
- Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper Use of fat emulsion
A nurse or other trained health professional will give you fat emulsion in a hospital. fat emulsion is given through a needle placed in one of your veins.
fat emulsion may sometimes be given at home to patients who do not need to be in the hospital or clinic. If you are using fat emulsion at home, your doctor or nurse will teach you how to prepare and inject the medicine. Be sure that you understand how to use the medicine, and do not deviate from the instructions given.
The dose of fat emulsion will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of fat emulsion. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For injection dosage form:
- For nutritional supplement:
- Adults and teenagers—Dose is based on patient's total nutrition requirements and patient's tolerance and must be determined by your doctor. The starting dose is 0.5 to 1 milliliter (mL) per minute injected slowly into a vein for 15 to 30 minutes. Your doctor may increase the dose if needed.
- Children—Use is not recommended.
- For nutritional supplement:
Precautions While Using fat emulsion
It is very important that your doctor check your progress weekly while you are receiving fat emulsions to make sure that fat emulsion does not cause unwanted effects. Blood tests may be needed to check for unwanted effects.
Allergic reactions may occur while you are using fat emulsion. Tell your doctor right away if you have the following symptoms: rapid, shallow breathing, trouble breathing, fast heartbeat, lightheadedness, dizziness, or fainting, nausea or vomiting, rash or itching skin, or a fever or chills.
fat emulsion may increase your risk of developing infections. Avoid being near people who are sick or have infections while you are using fat emulsion. Wash your hands often. Tell your doctor if you have any kind of infection before you start using fat emulsion. Also tell your doctor if you have ever had an infection that would not go away or an infection that kept coming back.
Call your doctor right away if you start to have a cough that won't go away, weight loss, night sweats, fever, chills, or flu-like symptoms, such as a runny or stuffy nose, headache, blurred vision, or feeling generally ill. These may be signs that you have an infection.
fat emulsion may cause a rare condition called fat overload syndrome. Tell your doctor right away if you have a fever, chills, cough, sore throat, right upper abdominal or stomach pain and fullness, or unusual bleeding, bruising, or weakness.
fat emulsion may cause parenteral nutrition associated liver disease (PNALD). This usually occurs in patients who have been receiving parenteral nutrition for a long time, especially preterm infants. Check with your doctor right away if you have dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes.
Call your doctor if you have redness, swelling, pain, or infection at the injection site.
Before you have any medical tests, tell the medical doctor in charge that you are using fat emulsion. The results of some tests may be affected by fat emulsion.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
fat emulsion Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:More common
- Bladder pain
- bloody or cloudy urine
- difficult, burning, or painful urination
- frequent urge to urinate
- lower back or side pain
- sore throat
- Back pain
- fast heartbeat
- shortness of breath
- weakness or lightheadedness
- Abdominal or stomach pain
- changes in skin color
- changes in urination
- fruit-like breath odor
- increased thirst
- swelling and redness in the lower leg
- unusual bleeding or bruising
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Redness, swelling, or pain at the injection site
- Itchy skin
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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- Drug class: intravenous nutritional products