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Ciprofloxacin (Intratympanic)

sip-roe-FLOX-a-sin

Medically reviewed on Oct 4, 2018

Commonly used brand name(s)

In the U.S.

  • Otiprio

Available Dosage Forms:

  • Suspension

Therapeutic Class: Antibiotic

Chemical Class: Fluoroquinolone

Uses For ciprofloxacin

Ciprofloxacin ear suspension is used to treat bilateral otitis media with effusion (middle ear infection with thick or sticky fluid behind the eardrum) in children undergoing surgical placement of tubes in the ears. Ciprofloxacin belongs to the class of medicines known as fluoroquinolone antibiotics. It works by killing the bacteria or preventing their growth.

Ciprofloxacin is to be given by or under the direct supervision of your doctor.

Before Using ciprofloxacin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ciprofloxacin, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to ciprofloxacin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ciprofloxacin ear suspension in children. However, safety and efficacy have not been established in children younger than 6 months of age.

Geriatric

No information is available on the relationship of age to the effects of ciprofloxacin ear suspension in geriatric patients.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving ciprofloxacin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using ciprofloxacin with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Agomelatine
  • Amifampridine
  • Amisulpride
  • Bepridil
  • Cisapride
  • Dronedarone
  • Flibanserin
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Tizanidine
  • Ziprasidone

Using ciprofloxacin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acalabrutinib
  • Acarbose
  • Acecainide
  • Acetohexamide
  • Alfentanil
  • Alfuzosin
  • Alogliptin
  • Alosetron
  • Amiodarone
  • Amitriptyline
  • Amoxapine
  • Anagrelide
  • Apomorphine
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Astemizole
  • Azimilide
  • Azithromycin
  • Bendamustine
  • Benfluorex
  • Benzhydrocodone
  • Betamethasone
  • Bosutinib
  • Bretylium
  • Budesonide
  • Buprenorphine
  • Buserelin
  • Canagliflozin
  • Chlorpromazine
  • Chlorpropamide
  • Cholera Vaccine, Live
  • Cilostazol
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clozapine
  • Codeine
  • Corticotropin
  • Cortisone
  • Cosyntropin
  • Crizotinib
  • Cyclobenzaprine
  • Dabrafenib
  • Dapagliflozin
  • Dasatinib
  • Deflazacort
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Deutetrabenazine
  • Dexamethasone
  • Dihydrocodeine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Droperidol
  • Efavirenz
  • Eliglustat
  • Eltrombopag
  • Encorafenib
  • Erlotinib
  • Ertugliflozin
  • Erythromycin
  • Escitalopram
  • Exenatide
  • Fentanyl
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fludrocortisone
  • Fluocortolone
  • Fluoxetine
  • Foscarnet
  • Gatifloxacin
  • Gemifloxacin
  • Gliclazide
  • Glimepiride
  • Glipizide
  • Gliquidone
  • Glyburide
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Histrelin
  • Hydrocodone
  • Hydrocortisone
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibrutinib
  • Ibutilide
  • Ifosfamide
  • Iloperidone
  • Imipramine
  • Inotuzumab Ozogamicin
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Bovine
  • Insulin Degludec
  • Insulin Detemir
  • Insulin Glargine, Recombinant
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Ivacaftor
  • Ivosidenib
  • Ketoconazole
  • Lapatinib
  • Leuprolide
  • Levofloxacin
  • Linagliptin
  • Liraglutide
  • Lofexidine
  • Lopinavir
  • Lumefantrine
  • Lurasidone
  • Macimorelin
  • Mefloquine
  • Meperidine
  • Metformin
  • Methadone
  • Methylprednisolone
  • Metronidazole
  • Mifepristone
  • Miglitol
  • Moricizine
  • Moxifloxacin
  • Nafarelin
  • Naloxegol
  • Nateglinide
  • Neratinib
  • Nilotinib
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Olaparib
  • Ondansetron
  • Osimertinib
  • Oxycodone
  • Paliperidone
  • Panobinostat
  • Pasireotide
  • Pazopanib
  • Pentazocine
  • Pimavanserin
  • Pioglitazone
  • Pirfenidone
  • Pitolisant
  • Pomalidomide
  • Posaconazole
  • Pramlintide
  • Prednisolone
  • Prednisone
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Rasagiline
  • Repaglinide
  • Ribociclib
  • Rosiglitazone
  • Salmeterol
  • Saxagliptin
  • Sematilide
  • Sertraline
  • Sevoflurane
  • Simeprevir
  • Simvastatin
  • Sitagliptin
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sonidegib
  • Sorafenib
  • Sotalol
  • Sufentanil
  • Sulpiride
  • Sunitinib
  • Tacrolimus
  • Tasimelteon
  • Tedisamil
  • Telavancin
  • Telithromycin
  • Tetrabenazine
  • Tezacaftor
  • Theophylline
  • Tolazamide
  • Tolbutamide
  • Tolvaptan
  • Toremifene
  • Tramadol
  • Trazodone
  • Triamcinolone
  • Trifluoperazine
  • Trimipramine
  • Triptorelin
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venetoclax
  • Vildagliptin
  • Vinflunine
  • Voriconazole
  • Warfarin
  • Zolpidem
  • Zuclopenthixol

Using ciprofloxacin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aceclofenac
  • Aminolevulinic Acid
  • Chloroquine
  • Cyclosporine
  • Diclofenac
  • Dutasteride
  • Fosphenytoin
  • Itraconazole
  • Lanthanum Carbonate
  • Mycophenolate Mofetil
  • Olanzapine
  • Phenytoin
  • Probenecid
  • Rifapentine
  • Ropinirole
  • Ropivacaine
  • Sildenafil

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using ciprofloxacin with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use ciprofloxacin, or give you special instructions about the use of food, alcohol, or tobacco.

  • Caffeine

Proper Use of ciprofloxacin

A doctor or other healthcare professional will give your child ciprofloxacin. Ciprofloxacin is to be given through a needle into your child's middle ear.

Precautions While Using ciprofloxacin

Your doctor will check your child's progress closely while you are receiving ciprofloxacin. This will allow your doctor to see if the medicine is working properly and to decide if your child should continue to receive it.

Call your child's doctor right away if your child has fluid that continues to drain from the ear beyond the first few days after the ear tube surgery, or if the ear becomes painful.

Ciprofloxacin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

  • Fever
  • headache
  • muscle aches
  • sore throat
  • stuffy or runny nose
  • unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Irritability

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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