Ciprofloxacin and hydrocortisone (Otic)
sip-roe-FLOX-a-sin hye-droe-KLOR-ide, hye-droe-KOR-ti-sone
Medically reviewed on June 7, 2018
Commonly used brand name(s)
In the U.S.
- Cipro HC
- Cipro Hc
Available Dosage Forms:
Therapeutic Class: Anti-Infective/Anti-Inflammatory Combination
Pharmacologic Class: Adrenal Glucocorticoid
Chemical Class: Ciprofloxacin
Uses For This Medicine
Ciprofloxacin and hydrocortisone is a combination medicine used to treat otitis externa. Otitis externa, also known as Swimmer's ear, is an infection of the outer ear canal caused by bacteria. The ear canal and outer part of the ear may be swollen, red, and painful.
Ciprofloxacin belongs to the class of medicines known as fluoroquinolone antibiotics. It works by killing the bacteria or preventing their growth. Hydrocortisone is a corticosteroid (cortisone-like medicine) that is used to relieve the redness, itching, and swelling caused by ear infections.
Ciprofloxacin and hydrocortisone is available only with your doctor's prescription.
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ciprofloxacin and hydrocortisone, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to ciprofloxacin and hydrocortisone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ciprofloxacin and hydrocortisone combination in children.
No information is available on the relationship of age to the effects of ciprofloxacin and hydrocortisone combination in geriatric patients.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking ciprofloxacin and hydrocortisone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using ciprofloxacin and hydrocortisone with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Rotavirus Vaccine, Live
Using ciprofloxacin and hydrocortisone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Amtolmetin Guacil
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Cholera Vaccine, Live
- Choline Salicylate
- Doxorubicin Hydrochloride Liposome
- Flufenamic Acid
- Inotuzumab Ozogamicin
- Insulin Aspart, Recombinant
- Insulin Bovine
- Insulin Degludec
- Insulin Detemir
- Insulin Glargine, Recombinant
- Insulin Glulisine
- Insulin Lispro, Recombinant
- Mefenamic Acid
- Niflumic Acid
- Nimesulide Beta Cyclodextrin
- Salicylic Acid
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
- Sodium Salicylate
- Tiaprofenic Acid
- Tolfenamic Acid
Using ciprofloxacin and hydrocortisone with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aminolevulinic Acid
- Lanthanum Carbonate
- Mycophenolate Mofetil
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using ciprofloxacin and hydrocortisone with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use ciprofloxacin and hydrocortisone, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of ciprofloxacin and hydrocortisone. Make sure you tell your doctor if you have any other medical problems, especially:
- Viral ear infections (e.g., varicella or herpes simplex)—Should not be used in patients with these conditions.
Proper Use of This Medicine
Ciprofloxacin and hydrocortisone is to be used only in the ear. Do not use it in the eyes and do not take it by mouth. If ciprofloxacin and hydrocortisone is accidently swallowed, call your doctor right away.
It is important that the infected ear remains clean and dry. When bathing, avoid getting the infected ear wet. Avoid swimming unless your doctor has instructed you otherwise.
To use the ear drops:
- Wash your hands thoroughly with soap and water.
- Hold the bottle in your hands for 1 or 2 minutes to warm up the solution before putting it in your ear. Putting a cold solution in your ear could cause you to become dizzy.
- Shake the bottle well.
- Lie down on your side with your infected ear facing up.
- Put the drops in the infected ear. You should remain on your side for at least one minute.
- Repeat the above steps if both ears are infected.
To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the ear). Also, keep the container tightly closed.
Keep using ciprofloxacin and hydrocortisone for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon. Do not miss any doses.
The dose of ciprofloxacin and hydrocortisone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of ciprofloxacin and hydrocortisone. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For ear drops dosage form:
- For ear infections:
- Adults and children above 1 year of age—Place 3 drops in the affected ear two times a day.
- Children younger than 1 year of age—Use and dose must be determined by your doctor.
- For ear infections:
If you miss a dose of ciprofloxacin and hydrocortisone, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions While Using This Medicine
If your symptoms do not improve, or if they become worse, check with your doctor.
Ciprofloxacin and hydrocortisone may cause serious allergic reactions including anaphylaxis, which can be life-threatening and require immediate medical attention. Stop using ciprofloxacin and hydrocortisone and call your doctor right away if you have itching; hives; hoarseness; rash; shortness of breath; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth.
This Medicine Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Incidence not known
- Blistering, crusting, irritation, itching, or reddening of the skin
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- cracked, dry, or scaly skin
- hives or welts
- redness of the skin
- skin rash
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- hair loss or thinning of hair
- headache, severe and throbbing
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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