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Ciprofloxacin / hydrocortisone otic Side Effects

For the Consumer

Applies to ciprofloxacin / hydrocortisone otic: otic suspension

Along with its needed effects, ciprofloxacin / hydrocortisone otic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ciprofloxacin / hydrocortisone otic:

Incidence not known
  • Blistering, crusting, irritation, itching, or reddening of the skin
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • cracked, dry, or scaly skin
  • hives or welts
  • itching
  • redness of the skin
  • skin rash
  • swelling

Some side effects of ciprofloxacin / hydrocortisone otic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Headache
Incidence not known
  • Cough
  • hair loss or thinning of hair
  • headache, severe and throbbing

For Healthcare Professionals

Applies to ciprofloxacin / hydrocortisone otic: otic suspension


The most commonly occurring side effects included headache, fever, and pruritus.[Ref]


Common (1% to 10%): Fever, infection, otitis externa (non-treated ear), otitis media
Uncommon (0.1% to 1%): Ear disorder, full sensation of the ear, medication residue
Postmarketing reports: Ear congestion, ear discomfort, ear pain, hearing disorder, hypoacusis, tinnitus[Ref]

Nervous system

Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Hypoesthesia, paresthesia
Frequency not reported: Migraine
Postmarketing reports: Dizziness, hypesthesia[Ref]


Common (1% to 10%): Pruritus
Uncommon (0.1% to 1%): Rash, urticaria
Frequency not reported: Alopecia, fungal dermatitis
Postmarketing reports: Fungal skin infection, skin exfoliation[Ref]


Postmarketing reports: Ear canal erythema, ear pruritus[Ref]


Common (1% to 10%): Nausea[Ref]


Frequency not reported: Cough[Ref]


1. "Product Information. Cipro HC Otic (ciprofloxacin-hydrocortisone otic)." Bayer, West Haven, CT.

2. Cerner Multum, Inc. "Australian Product Information." O 0

Some side effects of ciprofloxacin / hydrocortisone otic may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.