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Ciprofloxacin / hydrocortisone otic Side Effects

Medically reviewed by Last updated on Feb 24, 2023.

Applies to ciprofloxacin/hydrocortisone otic: otic suspension.

Serious side effects

Along with its needed effects, ciprofloxacin/hydrocortisone otic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ciprofloxacin / hydrocortisone otic:

Incidence not known

  • Blistering, crusting, irritation, itching, or reddening of the skin
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • cracked, dry, or scaly skin
  • hives or welts
  • itching
  • redness of the skin
  • skin rash
  • swelling

Other side effects

Some side effects of ciprofloxacin / hydrocortisone otic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Incidence not known

For Healthcare Professionals

Applies to ciprofloxacin / hydrocortisone otic: otic suspension.


The most commonly occurring side effects included headache, fever, and pruritus.[Ref]


Common (1% to 10%): Fever, otitis externa (non-treated ear), otitis media

Uncommon (0.1% to 1%): Full sensation of the ear

Postmarketing reports: Hearing disorder, hypoacusis, tinnitus[Ref]


Common (1% to 10%): Pruritus

Uncommon (0.1% to 1%): Rash, urticaria

Frequency not reported: Alopecia, fungal dermatitis

Postmarketing reports: Fungal skin infection, skin exfoliation[Ref]

Nervous system

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Hypesthesia, paresthesia

Frequency not reported: Migraine

Postmarketing reports: Dizziness[Ref]


Common (1% to 10%): Nausea[Ref]


Common (1% to 10%): Infection[Ref]


Uncommon (0.1% to 1%): Ear disorder, ear pain

Postmarketing reports: Ear canal erythema, ear congestion, ear discomfort, ear pruritus, medication residue with/without symptoms[Ref]


Frequency not reported: Cough[Ref]


Postmarketing reports: Blurred vision


1. Product Information. Cipro HC (ciprofloxacin-hydrocortisone otic). Bayer.

2. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.