Tirzepatide and Fatigue: What Users Say (Page 2)

• Anonymous
• Taken for less than 1 month
• January 12, 2025

Tirzepatide for Type 2 Diabetes "Mounjaro has helped me bring down my A1C. I'm only on a relatively low dose, but I am experiencing troubling side effects: stomach pain, indigestion, nausea, fatigue. I have the side effects mostly a day or two after the injection. I noticed a slight weight loss at first, but I think I gained the weight back somehow."

• agm...
• Taken for 1 to 6 months
• December 18, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "I have been on Zepbound for 16 weeks. I have lost 23 lb. I am a 6'3" 74-year-old man. I wanted a kick start to get to my goal, which I am at. Except for three weeks at 5 mg, I have been on 2.5 and am now after a brief go at 5 mg. My experience has been generally acceptable, but nausea and fatigue are a real challenge. No vomiting or diarrhea. I have had some acid reflux. The key has been to eat good clean food and stay away from fried or greasy. I have reduced my alcohol intake, but they are empty calories, and why do it? It just makes it tougher. The reason I drink some is usually social, but I have found it easier to abstain than I expected. Here's the deal: I think people lose weight on these drugs because they don't want to get sick and choose to behave and stay at a calorie deficit, and bingo, the math kicks in. It's not rocket science. I have taken a week off while on an overseas trip. Again, I didn't want to get sick. I am about to take another week off."

• Ann...
• Taken for less than 1 month
• May 31, 2023

Tirzepatide for Type 2 Diabetes "I am starting week three. As others have stated, it changed my relationship with food. I no longer focus or have cravings for salty and sweet, carbs, beginning day 3. No urge for late-night snacking. I can't eat carbs like potatoes or bread, or I get a stomach ache. A big improvement – I was so fatigued before, I could barely make it through the day, and now I have the energy to go into the pool and do some gentle exercising. I just don't get hungry. I was able to drop pop completely for water. I don't know what is in this medicine, but it really has made a profound impact on my life. I've lost 6 pounds so far, but it feels like I've lost a couple of inches in my clothes. Highly recommend."

• sve...
• Taken for 1 to 6 months
• March 1, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I have been taking Mounjaro for 4 months and have lost 20 lbs. I am currently taking 7.5 mg, and since I have been on this dosage, I have experienced nausea, stomach cramps, heartburn, and fatigue. I plan on lowering my dosage to maintain."

• Kat...
• Taken for less than 1 month
• May 15, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I started 2.5 mg of Mounjaro 5 days ago and have already lost 5 pounds. It makes me super thirsty, so I'm downing the water, which is a plus. I am not hungry at all and have to force myself to eat throughout the day. I am pre-diabetic with a fatty liver, so it's super important that I get my weight down for my health and happiness. I'm a 62-year-old woman, 5'11, 204 starting weight. As far as side effects, I'm not feeling any except I'm thirsty and don't have much energy. I know I'll feel better when I get down in size. I'm super excited about being thin again. I don't want anyone to see me at this weight, this weight gain has affected my life in so many ways. Fingers crossed it keeps working."

• Hon...
• Taken for 1 to 6 months
• October 6, 2022

Tirzepatide "I have been taking Mounjaro for 7 weeks. 4 weeks of that I was on the 2.5 mg dose and lost 15 lbs by the 4th week. The last 3 weeks I've been on the 5 mg and I've lost ZERO lbs. Seems kind of useless to take when you have all the side effects (constipation, diarrhea, bloating, gas, nausea, headache, severe fatigue) for 3 weeks straight with no weight loss. I am considering going off this medication, I think it was all just hype. I've also stopped having periods. 40 years old, SW 199, CW 185, GW 140. Also following website food/calories recommendations. I have no other disease, just obesity."

• Joh...
• Taken for less than 1 month
• September 26, 2022

Tirzepatide "I’m on 5 mg, and the good news is I am not hungry at all, as a matter of fact, the thought of food makes me sick. The bad news is get ready to feel sick all day, like nausea, upset stomach, dizziness, and extreme fatigue. Getting up in the morning, even after 8 hours of sleep, is a task."

• Chi...
• Taken for 6 months to 1 year
• January 28, 2023

Tirzepatide for Type 2 Diabetes "This medication works well for weight loss. I have been on it for 6 months and have lost 40 pounds, to where I am within 10 pounds of a normal weight. I’ve been on all of the doses. The gastro effects were very hard at first, but did go away. The more difficult and harder-to-tolerate side effects for me are increased heart rate and extreme fatigue, almost flu-like for 5 days after taking each shot. It makes me not want to get out of bed at all. It’s pretty close to depression. I’m trying to space out the medication to maintain my weight loss but not feel like I got run over by a truck all the time."

• Lis...
• Taken for 1 to 6 months
• March 5, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "My experience is a lot better than I was expecting. I'm on the 2.5 mg a week. So far, the side effects are manageable. I barely get nauseous, but the constipation is real. I really like the once-a-week dosage because I don't particularly care for needles. My weight loss is slow, mainly due to a lack of working out. I'm extremely fatigued and just want to rest. The fatigue hits me early in the morning and late in the afternoon. Stay hydrated!"

• Chi...
• Taken for 6 months to 1 year
• June 15, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I have been on Mounjaro for almost a year. Started at 194 lbs, now averaging 145-150 lbs. In the beginning, I had the usual gastro effects - upset stomach, diarrhea, and no appetite even for water. Despite eating low calories, I lost slowly, about 1 lb a week. I had no energy to work out. If I tried staying on lower doses to minimize side effects, then the appetite would come back. After a few months, the gastro effects mostly went away, and I am left with sulfur burps, fatigue, irritability, and a general meh attitude about everything. I am someone who I would say has an addictive personality, and addiction runs in my family, and this drug works on your reward systems as well, so I’m not surprised it takes away my motivation. Despite the bad, it’s the only thing that has worked for me for weight loss. Currently, I take the injection every 14 days to minimize side effects and also to keep it affordable. Doing this keeps me at the weight I’m at, which I would like to be about 10 pounds less."

• Pro...
• Taken for 6 months to 1 year
• February 25, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I’ve been on Zepbound since 8/1/24 (305 lbs, 5’6). So far, I lost 65 lbs, I’m 45 lbs away from my goal. My current dose is 10 mg. I experience side effects within 24 hours of injection administration, ranging from nausea, vomiting, belching, diarrhea, abdominal pain, fatigue, and dizziness. The side effects last about 24-36 hours. The medication definitely decreases my appetite and cravings. My doctor stopped my BP medication as I continue losing weight and my BP readings are good. My husband has noticed that I stopped snoring, lol. My plan is to reach my weight goal and stop the medication. I have changed my relationship with food. I look at food more as fuel for my body instead of indulging and overeating. I also introduced portion control and exercise, mostly walking and swimming. My insurance covers the medication."

• Amy...
• Taken for 1 to 6 months
• October 21, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "I’ve lost about a pound per week, starting with the smallest dose and leveling up every month. I started at 187 pounds and am down to 172. Side effects: constipation, belching, and fatigue (probably due to not eating enough). I like the pens and got over my fear of the needle. Sometimes it leaves a red welt in my tummy, but not usually. The worst part about it is the cost. My insurance doesn’t cover it, even though I was obese, had pre-diabetes, and sleep apnea (which I didn’t have when I was thinner). Imagine how many health issues could be solved if people could use this to lose weight."

• Mcl...
• Taken for 6 months to 1 year
• February 16, 2025

For Weight Loss (Obesity/Overweight) "Started taking tirzepatide in June 2024 at a max of 10 mg and lost 66 pounds without working out. Side effects were an itchy, warm rash at injection sites, which I was told was a mild allergic reaction. Extreme fatigue, couldn’t work out, get up from the couch, or even go up the stairs. It never really went away. Extreme nausea every time I went up a dosage or overate. Lots of stomach pains, mostly in the beginning because I was still trying to eat what I normally do and got full way too easily. Can only eat one small meal a day. Easily dehydrated, still trying to work on that. Heart rate lowered significantly and I still don’t know why. Still taking it as of now, 2025, but I think I would have rather stayed at 7.5 mg because it was more comfortable, just lost less weight that way. Unfortunately, I know for a fact that I’d gain some weight back if I stopped taking it."

• Tum...
• Taken for less than 1 month
• November 2, 2022

For Weight Loss (Obesity/Overweight) "I started the 2.5 Mounjaro injection prescribed by my doctor a week ago to help lose weight. I was happy that the injection was super easy and didn’t hurt at all. The first 2 days I felt great! I had zero appetite, even on the first day, and had to force myself to eat. By the 3rd day… it was a nightmare! I had nonstop diarrhea, the kind you get with colonoscopy prep stuff! I also experienced horrible, sulfur-like belching, especially when getting up in the morning, and had extreme pain in my lower back. Then, last night, I had extremely forceful vomiting, which is crazy because I don’t really have anything in my system! I still have the horrible diarrhea 7 days later, also pretty extreme fatigue, slight heartburn, and a nauseated feeling. I am just praying this stuff gets out of my system ASAP! I just wish someone could tell me how long before I feel better! I will not be using the rest of my Mounjaro injections after the experience I’ve had this first week."

• Gre...
• October 15, 2023

Tirzepatide for Type 2 Diabetes "I am 5'9", 64 years old, and female. I weighed in at a high normal body weight, but my A1C was nearly 13. My doctor tried Metformin with fast and long-acting insulin and also Januvia, and my blood sugars were horribly unstable, dropping to 45 in the middle of the night and waking up over six hundred. I also have fatty liver disease with stage four cirrhosis. I've been on Mounjaro for eight weeks and lost 24 pounds, which still leaves me at the higher end of normal body weight, but my A1C fell to 7 after a month. I am on the 5 mg but wish I had stayed at 2.5 for a while, as the side effects like bloating, indigestion, and diarrhea have started again, and I don't really need a lot of weight loss. The fact that it breaks down fat in the liver and controls my diabetes is the best thing. The worst thing is the waves of nausea, fatigue, and dizzy spells I get in the first few days after taking it, but it's still worth it."

• Bec...
• Taken for 6 months to 1 year
• May 30, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I had insulin resistance and was overweight. I started taking Mounjaro and have lost 34 lbs and am now within 8 lbs of my goal weight. I have not increased my physical activity. My A1C has gone from 7.0 to 5.4. I started taking it 7 months ago. I have been on the 10 mg dosage for the last 2 months. I find that it is very easy to use. The side effects at first were nausea and diarrhea. They were very severe at first, but have calmed down and now I might experience some slight nausea the day after my injection. I also find that I really do not have any interest in food and do not feel hungry. I need to eat small meals of mostly protein and get full on very little food. Another side effect that seems to have gotten worse in the last 2 or 3 months is extreme fatigue. I find that I have very little energy."

• Jan...
• Taken for less than 1 month
• November 24, 2024

Tirzepatide for Type 2 Diabetes "I've only had 2 shots and 2 days until the next one. I find it very convenient to administer. However, I have had some nasty side effects! I've had diarrhea, nausea, vomiting, fatigue. I will continue taking the medication hoping the side effects will 'calm down.'"

• 215...
• Taken for 1 to 6 months
• November 11, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "First things first. I'm a 40-year-old woman. My height is 5'9", and my starting weight was 214. During my first month on Zepbound 2.5 mg, I experienced fatigue, dry mouth, and slight constipation. I'm on my second month dosage of 5 mg now, and I'm experiencing nausea and migraines. This is my sixth injection, and the weight fell off during the first month, and now I'm at a standstill. I'm weighing in at 195 for the last 2 weeks. During my first month, I had no carbs at all. I made sure I had at least 120 g of protein a day, and I weight trained four times a week, getting my goal of 10,000 steps a day. I haven't kept that same training routine these past two weeks, which is why I probably haven't lost any weight. I'd say the medicine really works. I'm not looking to stay on long-term. Since I hit 40, I've struggled with weight, perimenopause, etc. This has been a game changer."

• Kat...
• Taken for 1 to 6 months
• September 2, 2024

Tirzepatide for Type 2 Diabetes "I began my journey on April 12th, 2024. I'm currently on my second dose of 7.5. A bit more stomach issues, diarrhea, and extreme fatigue. No desire to eat whatsoever. Since I've started, I have lost a total of 50 lbs. as of 9/2/24. Yes, I'm Type 2 diabetic, but I wanted to give this medication a try to see if it would be of any help for me to lose weight. It has far exceeded my expectations! It's been a bit rough, but I'm seeing great results. I'll continue on this journey with hopes of meeting my own personal weight loss goals."

• Liz...
• Taken for 1 to 2 years
• August 14, 2024

For Weight Loss (Obesity/Overweight) "Good results were decreased appetite, decreased alcohol cravings, less hot flashes, skin tags shrivel up, less hair on face, lips, chin, weight loss, and food noise gone! Side effects were nausea, increased tiredness, fatigue, constipation, and skin sensitivity."

• Mea...
• Taken for less than 1 month
• October 14, 2022

For Weight Loss (Obesity/Overweight) "I started the Mounjaro 2 weeks and 6 days ago for obesity and due for my 3rd shot tomorrow. I started on the 2.5 mg dose. After my 1st injection, I felt fine that first day. The second day, I woke up feeling dizzy, almost like I was drunk, and extremely fatigued and exhausted. I felt almost back to normal by noon but was very nauseous the whole day. I spent the majority of the first week nauseous and had a significantly decreased appetite. I did not lose any weight. In the second week, nausea was a little worse. I noticed that if I ate a bite occasionally, I wouldn’t get as nauseous. I was barely eating, but as the week went on, my appetite turned normal. Also, at the end of the 3rd day of my 2nd week, I had a severe headache. I have Crohn’s, and I am used to having diarrhea daily. I have been slightly constipated, the 2nd week worse than the 1st. But I have actually gained 2.2 lb! How? I don’t eat much due to nausea! I will stay the course for now… My appetite is definitely down, little cravings."

• CMH...
• Taken for 6 months to 1 year
• July 13, 2023

For Weight Loss (Obesity/Overweight) "Started Jan 6 at 191. 57F, 5'6'. July 12, 143. So almost 50# in 6 mo. First month or so on 2.5, I had mild nausea (Zofran worked great), indigestion (Pepcid chewables for that), and occasional constipation. Diarrhea maybe twice. Experienced some fatigue initially, but likely the result of very low calorie intake. Have been on 5 mg since, with only mild constipation. This drug is an absolute game changer for me. I had tried for almost 2 years to drop the weight with diet and exercise with basically zero success. Now I'm approaching my lowest adult weight with minimal effort! Biggest downfall is having to spend money on new smaller clothes."

• Rub...
• Taken for 6 months to 1 year
• May 23, 2023

For Weight Loss (Obesity/Overweight) "This has been a lifesaver for me! I struggled with weight loss, fatigue, brain fog, decreased libido, and hormonal imbalances. I didn't realize how bad I felt until I started feeling better. I have been on it for about 6 months now, and I feel like I have my life back. I have increased energy, better sleep, improved vision, lowered blood pressure, regained my libido, balanced my hormones, improved focus, and enhanced my overall mental well-being. I hope that more research will be conducted on this, as it could potentially help many others who have experienced these symptoms and have been dismissed by doctors, who have been told it's just a normal part of aging, and who have made lifestyle changes without seeing any results."

• Hea...
• Taken for 1 to 6 months
• December 16, 2024

For Weight Loss (Obesity/Overweight) "The medication was easy to use with its once-weekly injections. After my first injection, I experienced strange, all-over skin aching, especially in my posterior neck. This resolved in a day or two and didn’t happen with subsequent injections. It noticeably decreased my appetite. I also noticed fatigue and significant nausea, more so in the first few days following the injection. I haven’t noticed the amount of weight loss I was expecting given how little I’m eating. Only about 10 pounds in three months."

• Mk6...
• Taken for 1 to 6 months
• March 10, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I started in January 2025 with the 2.5 dose. For the first two weeks, I experienced nausea and diarrhea off and on. For the last two weeks, I was fine. I am on my second week of 5 mg. The first week, I was so sick - I take the shot late Friday afternoon - I was in bed most of the day on Saturday with nausea and fatigue. I did vomit once. Sunday was the same. The rest of the week, I felt fine. Second shot last Friday - I was okay on Saturday - able to function but very nauseous. Woke up on Sunday and spent most of the day in bed due to nausea and fatigue. The anti-nausea medicine helps but not so much for me. Today I am functioning with some nausea. The benefits of this drug are obvious. I don't eat as much as I did before the medicine. I've lost 16 lbs so far. The nausea bothers me. I should be able to function and not get sick every weekend after a shot. I no longer have diarrhea - I am constipated instead. When I take Miralax, I cannot think about it or I get sick."