Tirzepatide and Constipation: What Users Say (Page 3)

• chu...
• Taken for 1 to 6 months
• June 1, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "5’ 8” and 272 was my starting stats. I did four weeks of 2.5 then went up to 5.0. I am only on my 6th week (4 2.5s and 2 5.0s) and I have already lost 30 pounds. Now, at 242, I am looking to take off another 30-50 pounds. I am trying to be put on a list to have a transplant and have to lose a certain amount of weight to make the list. I give the medication a 100% A+. If you need to drop weight, this is a great medication. Side effects: Constipation. Drink as much water as you can and be prepared to take laxatives to poo. I’m talking rock pebbles harder than pleasing a Gold-digger on a date, you’ll definitely have to take some laxatives to poo. I suggest flavoring your water. It helps. Candy: You will crave sugary candy like Gobstoppers, Sour Patch Kids, Skittles, pretty much anything you can get your hands on. Try dark chocolate almonds and just small nibbles of candy when you get really, really sleepy. Bottom line: It works! It's worth the hard rock poo."

• Jan...
• Taken for 1 to 6 months
• November 30, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Minimal weight loss in 5 weeks. Continual feeling of acidic stomach, some reflux. Constipation if not taking a stool softener. It has decreased my appetite. It also lets me know if I eat a food high in flour or sugar with severe acid reflux. Overall, I feel miserable while on it."

• Jus...
• Taken for 1 to 6 months
• January 15, 2023

Tirzepatide for Type 2 Diabetes "I’ve been taking Mounjaro now for 4 months. I was prescribed it to treat my type 2 diabetes as well as for weight loss. Let me just say this drug has been a miracle! I started out at 268 lbs (5 ft 6 in male), I am now at 225 lbs! Over 40 pounds in 4 months! The only other weight loss program that helped me like this was the military! Now let me just say it’s not all Mounjaro, I’ve changed my eating habits and changed what foods I’m actually eating, and boom, working like a dream. My A1C has also dropped from 7.5% to 5.8%, this drug is an amazing stepping stone to a healthier life. The only side effects I’ve experienced since starting are loss of appetite and constipation, not too bad in my opinion!"

• fat...
• Taken for 1 to 6 months
• June 16, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Just under 5 months. Down 36 pounds from size 16 to a 12/14. Almost 50. 5'9'. F. Started at 2.5, of course. Currently on 10mg. The biggest issue for me has been finding the medication in stock. It makes me not think of food until I'm hungry and then I eat a little something. I stay full a long time. I can only assume this is what normal people without food issues are like. I have lost upwards of 100 pounds with very hard work over a period of 2-4 years at two different times in my life. I need help this time around. Even when I was doing well with diet and exercise prior to this medication being available, all I did is think about how many calories I had eaten and how many I had left. I don't even count calories now. I have almost no interest in eating. The day before my injection is due, I am more hungry but still not eating more than 1800c. No real side effects aside from constipation in the beginning. It's amazing."

• Lis...
• Taken for 6 months to 1 year
• March 29, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "Best method for weight loss and keeping the weight off. I've lost over 100 lbs and am finally comfortable in my skin again. When you change mg dosage, fatigue could be concerning, and it does happen. Working out helps, making sure you stay hydrated, and working out was the biggest help for me. I did have constipation, and it was managed. I did have hair thinning and started taking Nutrafol. I've struggled with my weight my entire life. Not anymore. I wish we could add photos, but we can't. Portion food sizes of what you can eat are minimized. The sugar cravings were gone. Not only did those cravings disappear, but so did the cravings for food that your body turns to sugar. For example, I haven't eaten a potato chip in over 7 months. No desire for breads, mayo, Miracle Whip, and numerous other things. I FEEL so much better. It is costly, but so is poor health and obesity. I wish big pharma would realize how many Americans struggle with obesity and cover this through insurance."

• peb...
• Taken for 1 to 6 months
• February 26, 2023

Tirzepatide for Type 2 Diabetes "Started this 7 weeks ago and have one more injection. The first set was at 2.5 mg from the gynecologist. Within the first week, I lost 5 pounds and by week 5 I saw a huge difference! I went from a 22 waist to a true size 18 and still shrinking. I was having trouble catching my breath before I started this. I had a couple of pains in my stomach, similar to gas pains like clockwork, the day after the injection. But it was bearable. Sometimes I get a smelly burp issue. But now I have lost 20 pounds at week 7 and feel amazing. Please do yourself a favor and take fiber daily, this medicine will get you constipated."

• Jud...
• Taken for 1 to 6 months
• January 22, 2025

Tirzepatide for Type 2 Diabetes "I started Mounjaro 8 weeks ago. I’m 69 years old with T2D and weighing 234 lbs. I now weigh 214. I start on 7.5 this weekend. I have had light nausea and light constipation, and the lovely burps, but other than that, all is good. I eat better, no hunger 24/7, and I feel so much better. No more metformin. Yay!!!!"

• Wee...
• Taken for 1 to 6 months
• August 1, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Started on 2.5 for 4 weeks, lost 4.5 kg, forgot to eat, total loss of appetite, felt dizzy, probably because I wasn't drinking enough water. Week 5, went to 5 mg, lost just over 1 kg. Now in week 6, have been constipated, having to take laxative, will finish the 5 mg jab another 2 weeks and see how I feel. Amazing result in never hungry and, as a crisp lover, could never have another packet with all the salt, yuk! Usually have chicken fillets, chips, and bread and butter, just don't want bread at all, can only have two small chicken pieces, nothing else, and only because I know I have to eat something. Went to McDonald's with the grandkids, haven't told anyone I'm on this drug. Kids were happy as Nana couldn't finish her burger and chips. Have started craving fruit, which I never eat, will try and carry on and see if I can be sensible."

• mou...
• Taken for less than 1 month
• June 1, 2023

Tirzepatide for Type 2 Diabetes "My husband suffered from severe nausea, mostly at night, but also from loss of appetite, constipation, and increased fatigue. He could not even get out of bed after one injection. He will not take a second dose."

• Son...
• Taken for 1 to 6 months
• March 19, 2025

Tirzepatide for Type 2 Diabetes "Started on 2.5 mg in December and have titrated up every 4 weeks to 12.5 mg currently. So far I have been losing 2-3 lbs a week and have lost 34 lb, and up until now I haven't really noted any serious side effects other than occasional constipation and slight nausea if I don't eat something small every few hours, or if I eat something really fatty. The last two titrations I have noticed some extreme fatigue and being cold on the first day after my shot, but then it usually starts to go away on the 2nd day and I feel better. I have also noticed that if I try to push through the tiredness and try exercising, I usually feel better. I have tried to stick to a 1200-1500 calorie diet and do eat a lot more fruits and veggies, and I feel better than I have in a long time. Overall, it’s been a good experience and I’m super excited to see how much more weight I can lose."

• S-L...
• Taken for 1 to 6 months
• November 6, 2022

Tirzepatide for Type 2 Diabetes "I tried to leave a review, but for some reason, it wasn't posted, so I will try again. My doctor took me off of Mounjaro recently. I developed large welts about 24 hours after I injected the 75 doses and 10. My doctor fears I am developing an allergic reaction, so I am going back to the rival insulin alternative. (I had more side effects with the Ozempic: exhaustion, extreme nausea, and constipation, but hopefully, over time, they go away this time.) Too bad, because I really wanted to stay on Mounjaro. It should be noted that I really like Mounjaro very much. Well-controlled sugar, once I was on my maintenance dose of 10. For some reason, I gained five pounds while on Mounjaro, I never lost weight, where I lost about 15 pounds on the other mentioned insulin alternative. It seems that other patients on other review sites have this welt issue too. The issue should be reported not only to the doctor, but per the request of the manufacturer, please report to them as well."

• WE...
• Taken for less than 1 month
• November 8, 2022

Tirzepatide for Type 2 Diabetes "Went to the doctor and asked for something to help lose weight. He prescribed this medication. Day 1 and 2... nothing. Day 3 woke up with horrible heartburn and sour sulfur burps and facts and was constipated. By day 3 evening, I no longer had constipation but just the opposite... diarrhea! And not just any kind, it was like yellow water and very acidic. It hurt! Had horrible gas and belching all day Saturday, and Sunday couldn't hardly leave the bathroom to go buy Imodium. Imodium helped with that, but the gas is now trapped, and my stomach hurts badly, and I am full of gas with bad heartburn and belching. I saw a correlation between fatty foods and severe side effects of this product. But unless you're a vegan, you eat fat, and that's a major problem with this product. It is now Monday night, and I cannot seem to get my work done, I hurt so badly. I will never take this product again, and I cannot in good conscience recommend it with all the terrible side effects. Shame on Mounjaro!"

• WVN...
• Taken for 1 to 6 months
• December 27, 2022

Tirzepatide for Type 2 Diabetes "I started on the 2.5 dose in October, my doctor felt that the weight loss would help with my joint pain and lower my A1C. From day 1, I was extremely nauseous, had no desire to eat, had sulfur burps, and had constipation. I spoke with my doctor, who encouraged me to ride it out. On week four, I was stepped up to the 5 mg dosage. The doctor called in Zofran for stomach issues. On week six, I called her and said I could no longer function. During this time, I was so fatigued and was having heart palpitations and was barely able to walk 20 feet without being totally exhausted. I chalked it up to being so nauseous and not eating. Then my legs started to burn like I had walked up a steep hill and felt so sore and bruised I could barely sit. That week, I had my follow-up appointment with my doctor. I told her about my symptoms, and she said that rhabdomyolysis is not a side effect of Mounjaro. I was never dehydrated, but my CK levels were still 440 two weeks off the medication! Eight weeks later, and no improvement!"

• Anonymous
• Taken for 1 to 6 months
• March 17, 2025

For Weight Loss (Obesity/Overweight) "I am on my fifth week today. Have very little appetite and burning in my throat and nausea. Have been constipated also. The burning in the throat is the worst. I told them and prescribed nausea pills. I took one tonight, but it's not helping. Feel like I am going to void. Took Roland. Nothing helps. I was on semaglutide 2 years ago and never had this burning in my throat. Constipated on both. Am losing weight faster after 4 weeks. Right now, I can’t even imagine increasing the dose because of this awful burning in my throat."

• L9-...
• Taken for 6 months to 1 year
• March 17, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I have lost 54 lbs. in 6 months. It’s been easy, my only issues have been constipation and some hair loss. I increased my dosage each month to 15 mg. I am now reducing my dosage to wean off the drug. I wish there was more information about stopping the drug. Also, I had to spend thousands of dollars because it’s so expensive. I worry about stopping the drug."

• Fat...
• Taken for 6 months to 1 year
• February 6, 2025

Tirzepatide for Type 2 Diabetes "My experience has been very good. I took drastic steps to change eating habits, cutting carbs where possible. Rather than eating chips at home, I go through 6 lbs of carrots per week. I divorced French fries. Aside from that, I still eat what I want when dining out. Dropped from 330 lbs to 262 lbs in 8 months. No side effects aside from constipation - daily fiber and stool softeners make that manageable. I feel that part of the weight loss was simply the change in diet, but the Mounjaro certainly helped. I'm on the 2.5 dosage."

• Duc...
• Taken for 1 to 6 months
• October 16, 2022

Tirzepatide for Type 2 Diabetes "I was using Ozempic, but Dr. switched to Mounjaro. It has been terrible! I lost a lot of weight on Ozempic but gained some back since being on Mounjaro. Also, my blood sugar rose 10-15 points since switching! I have had numerous side effects, mainly headaches and constipation. When giving it, it always seems to leak back out of my skin, and I've tried stomach, arms, thighs- all the same! I am not happy."

• MJs...
• Taken for 1 to 6 months
• February 17, 2023

Tirzepatide for Type 2 Diabetes "3.5 months from 2.5 mg to 5.0 mg. Even before starting 7.5 mg, my experience has been positive. Less stressful, as if my cortisol levels are low. No desire to drink alcoholic beverages. Appetite suppressed, loss of inches before any noticeable weight loss. Slow loss of excess weight. PCOS symptoms have mostly disappeared, however, when refills were not available, all symptoms almost immediately presented again, including desire to snack. Constipation is noticeable at 5.0 mg. Starting 7.5 mg now. 22 lb of excess weight lost after 3.5 months of use."

• Mar...
• Taken for 1 to 6 months
• October 28, 2024

Tirzepatide for Type 2 Diabetes "I started taking Mounjaro 2.5 mg in March of this year (2024). Every month, my doctor increased my dose to the next level. I was put on the medication to help with my A1C because it would go up and down but not at a normal number. After 3 months, it went from a 7 to 4.5. I was so happy with the result. I am currently on 15 mg and I am down 50 lbs (over 6 months) and A1C is staying at 4.5. My original goal was 30 lbs by September and 60 by next March. I am so excited that I am already close to my year weight goal loss. The only side effects that I have had were the sulfur burps, which I figured out how to control and prevent and stop. And occasional constipation, which I just increased fiber intake to help. Everyone's experience is different. I went into taking it and researching all the side effects and being careful. I am thankful to my doctor for helping me, and I am happy with the results so far."

• Kir...
• Taken for less than 1 month
• June 25, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Benefits: Completely stopped the food noise and cravings for fatty and sweet foods, decreased appetite within the first 2 days of injection. Injection not painful at all, tiny needle. Side effects: feelings of fatigue for 2 or 3 days after injection, can feel very bloated due to constipation. Feelings of a lump in the throat due to some acid reflux. Sometimes feel more emotional than normal. Increased periods, 2 periods within 1 month, very heavy and prolonged, appetite increased slightly on last 2 days before next injection due. Can feel shaky/weak if not eating enough calories due to decreased appetite. 1st month of use experience on 2.5 mg."

• Bri...
• Taken for 6 months to 1 year
• December 4, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Zepbound has been a godsend. I started at 244 lbs with a BMI of 36. I am down 60 lbs to 184. I started at the end of April, so just a little over 7 months. The only side effect I have had is the expected slow digestion, so you have constipation, with only having bowel movements every 2-3 days on average. However, some days you have a day where you have multiple movements in a day. Due to availability issues, I have not been on the proper dosing. Normally you start at 2.5 mg for the first month, then 5, 7.5, etc., for each month after until you max out at 15 mg. I started at 2.5 mg for the first month, but when I tried finding 5 mg, the only place was my insurance online pharmacy, and they only did 3-month prescriptions -- but 3 months at $100 (and the first month Eli Lilly gave me an $80 discount). I've only been able to find the 5 mg in order to not miss any doses. So, the good news is I was able to sustain the weight loss by staying at the same dose. If you can get it, it works great."

• ECT...
• Taken for 6 months to 1 year
• April 11, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "Effortlessly went from 250 lbs to 198 lbs in 9 months, with very minimal side effects! It took me this long to go through the gradual dosage increases. When I missed a few weeks here and there, I regained weight. I’ve been extra committed to the regularity of doses after that! My only side effects have been: some mild constipation (take mg citrate to fight that), very mild diarrhea, heartburn that increased as the dosage mg increased, although eating TUMS like candy took care of it (but expensive because I insist on having the TUMS that taste good to me), and injection site reactions (similar to a mosquito bite ≈ 3 days, managed with OTC cortisol cream and/or OTC roll-on 4% lidocaine). I used to have no off switch; was always hungry! Now, my mom (Wegovy) and I look at each other in amazement and ask, “Is this what it feels like to be normal?” She’s been up to 300 lbs, had bariatric surgery, we’ve both done keto, nothing lasted. She’s now 160!"

• J W...
• Taken for 1 to 6 months
• September 20, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "I am a 60 y/o female, 5’7” and 288# on August 2, 2024. I was borderline diabetic and felt as though something had to be done considering my family history of diabetes and heart disease. I began Zepbound at the 2.5 dose. Seven weeks later, I weigh 252 and am very happy with my progress. My goal weight is 185, which is realistic for my height. I’m not taking this to become thin, I’m taking it to become healthy. My adverse side effects have been severe constipation and gas, which are easily mitigated with laxatives and gas reducers. I am eating healthier and am no longer controlled by excessive sugar cravings. While I once ordered a large ice cream, I now order a small and split it with my husband. My diet consists primarily of vegetables, and I have to remind myself to include at least a little protein to balance my diet. I am focusing on my relationship with food so I can continue to succeed when I am no longer using the medication after 12 months. My co-pay is $25.00."

• CPA...
• Taken for 1 to 6 months
• July 17, 2024

Tirzepatide for Type 2 Diabetes "I started the medication in November of last year. I started with 5 mg and incrementally increased the dosage up to 15 mg. The small hypodermic needle made it easy to inject. At 10 mg, I reached a plateau with the weight loss. I eventually went up to 15 mg and stayed on that dose for 2 months. The primary reason for taking it was for type 2 diabetes, and I benefited from weight loss as I was also overweight. As of today, I have lost 35 lbs but stopped the Mounjaro about a month ago. My appetite seemed to slowly get back to normal, which is not a good thing. I also did intermittent fasting, so that helped a lot with the cravings, etc. I also get some bouts of constipation, but my diet made up for that. My urine smelled different. I pray there were no effects on my kidneys. My blood sugars are normal. My A1C is 5.2, so I chose to stop the medication and continue the weight loss journey naturally."

• Ala...
• Taken for 1 to 6 months
• January 4, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "My wife had been on Mounjaro for several months and had seen dramatic weight loss. Our bro-in-law had a prescription but had a reaction, so he gave his supply to me. (My insurance doesn't cover it.) After 5 months, I had lost 50+ lbs. In 15 months, my wife lost over 170 pounds. Both of us combined our course with a keto diet: low carbs, high fat, and protein. The wife's sisters had also seen similar results while also using the keto diet. I am not diabetic, but my wife is. She has cut her use of insulin to the bare minimum and will still occasionally have low blood sugar. While I have run out of my supply, I used 5, 7.5, and 10. My wife has had a more managed regimen, gradually increasing to her current 12.5. Our only real side effect has been constipation. We are trying to handle that with an increase in eating more fiber and fiber supplements, along with using laxatives. To deal with our decreased food intake, we are both also taking vitamin supplements."