Tirzepatide and Constipation: What Users Say (Page 2)

• Dee...
• Taken for 1 to 6 months
• April 6, 2025

For Weight Loss (Obesity/Overweight) "I started in January and have moved doses up monthly. This morning I took my 4th 7.5 mg dose. I did have a 2.5 mg pen malfunction and moved up to 5 a week early. I've been losing 1-3 pounds a week, for a total today of 28 lb loss. My goal is to lose 50. As far as side effects, they really aren't too bad for me. Daily Colace helps any constipation, which has not been much of an issue anyway. Occasional nausea is fleeting and is helped with Coke One. I know some are against drinking soda, but Coke One does not have sugar and has been my nausea cure for as long as it's been on the market. My appetite is diminished, but not gone. I've changed my eating pattern to several small, healthy mini-meals during the day instead of 3 'regular' meals. Zero cravings for junk food or much snacking at all. Part, I'm sure, is that I'm keeping those mini meals full of protein and vegetables. The only real issue that I've had is fatigue. It hits about an hour after the shot and lasts about 36 h."

• Sus...
• Taken for 1 to 6 months
• October 19, 2024

For Weight Loss (Obesity/Overweight) "Been taking Zepbound 2.5 mg for four weeks - just had my fifth injection last night. Started at 254 lbs. and have lost 18 lbs!! My last weigh-in was 236 lbs.! The only annoying side effect I had was mild constipation. I had no idea what food noise was until it was gone. Wow. Finally understand what it is to be normal. Not sure what my goal weight will be yet, somewhere between 175-150 lbs. I'm in my early 50s and finally confident I'll have sustainable weight loss."

• Hel...
• Taken for 1 to 6 months
• March 7, 2023

For Type 2 Diabetes "I know this med doesn't work for everyone, and some people have some pretty horrific side effects. Luckily, I am one of those people who it DOES work for. In 4 months, went from A1C of 7.5 to 5.0. All of my other regular labs are in normal range. Going off atorvastatin (10 mg for cholesterol) and lisinopril (10 mg for high blood pressure) soon. Also, lost 45 lbs. The only side effect worth mentioning is constipation, but I think I finally have a handle on that (with magnesium supplement). Started on 2.5 mg for 8 shots, 5.0 mg the rest of the time. My biggest problem is supply issues. I have a prescription for 7.5 mg but haven't been able to find any yet. Shortage is supposedly ending, so hopefully that will be resolved soon."

• NJ-...
• Taken for 1 to 6 months
• January 23, 2025

For Weight Loss (Obesity/Overweight) "I've finished my 5th month of Zepbound injections. The dose pen makes the injection simple and painless. It took me a few weeks to actually feel that this was changing my appetite or cravings, but once it did, I have no problem resisting the habitual munching. Although my diet changes have helped the amount of food I eat at one time, I don't get the full feeling that a lot of people talk about. So I have to know when to push away from the servings. This was prescribed for weight loss, but I do have sleep apnea as well. I've lost 20 lbs, which matches the estimated 1 lb per week under this med. My goal weight is a 40 lb reduction. The only side effects that I've noticed are primarily increased gas and constipation if I don't push the fluids. So far, it's been a positive experience and I look forward to added results."

• CJa...
• Taken for 1 to 6 months
• April 1, 2025

For Weight Loss (Obesity/Overweight) "I started 3 months ago with the 2 ml, then 5, and now 7.5. I have been nauseous every single day for those 3 months. I have been constipated almost every week. I finally am able to go. I noticed that after the injection, I vomit every time the next day. I am 5'7 and weighed 233. I am now 209. The nausea is sometimes unbearable. I feel like not taking this medicine. Everyone's body is different."

• Kim...
• Taken for 1 to 6 months
• June 19, 2023

For Weight Loss (Obesity/Overweight) "I am starting my 3rd month on Mounjaro. I have been overweight/obese most of my adult life. I have lost some weight but not as much as I expected. I feel terrible - I suffer with exhaustion, constipation, indigestion, depression, and nausea. I just do not feel good. It has sucked the joy out of my life. I used to exercise much more when I was not taking Mounjaro. I don't want to do anything. I am wondering if it is worth it?"

• She...
• Taken for 6 months to 1 year
• April 27, 2023

For Weight Loss (Obesity/Overweight) "In October 2022, I was pre-diabetic. My daughter had good luck with Mounjaro, so I went to my doctor to ask her if it might work for me. I am a 65-year-old female. I am 5'2" tall and weighed 182 lbs and wear size 16. I started Mounjaro in the middle of October 2022. Today, April 27, 2023, I weigh 122 lbs and wear a size 4. I am now just trying to maintain my weight. The side effect that I experienced was constipation, as I would only have a bowel movement once a week. I rarely experience hunger and have to remind myself to eat. I do not crave sugar or any other food. I started on the 2.5 mg dosage for a couple of months and then went to the 5 mg dosage for two months. I have been on 7.5 mg for the last few months. I stopped my acid reflux medicine last month and have not experienced any acid reflux since I stopped it. I have so much more energy now and feel great. I would highly recommend Mounjaro, it has changed my life."

• Mar...
• Taken for 1 to 6 months
• May 25, 2024

For Weight Loss (Obesity/Overweight) "Started using Zepbound in March 2024, at 2.5 mg. History of Obesity (BMI > 29) and Hypertension. Starting weight was 202 lb. and Blood Pressure Avg. of 153/90. As of today, May 24, 2024, currently on 10mg. My weight is currently 177 lb, having lost 25 lbs (12%) of starting weight. It was easy to learn how to use the injection pen, and it is a painless process. I am also exercising, running 4-5 days per week and weight training 2 days per week. Exercise is an important adjunct to weight loss treatment, and can help maintain muscle mass while losing weight. It is also imperative to eat foods rich in protein and green, leafy vegetables. Side effects have been minimal, with occasional constipation, which is remedied by using Miralax or similar products."

• Anonymous
• Taken for 6 months to 1 year
• April 24, 2023

For Weight Loss (Obesity/Overweight) "Obesity runs on my father's side, and my weight gain has been a lifelong struggle. I did my best, but by reaching 275 lbs at 50 years old, I knew I needed something more than all the traditional weight loss programs. I began taking Mounjaro in Nov 2022. My doctor did a low dose to start (1.5 mg). I experienced the more common side effects: sulfurous belching, heartburn, constipation for a day or two after the weekly injection, stomach feeling sour, etc. I manage these symptoms with my doctor's OTC recommendations. We advanced to a 5.0 mg dose, and I continue to experience these side effects, but they are becoming more manageable. It's the end of April, and I've lost 40 lbs so far. I have more energy, manage my diet better/easier, and make better eating choices. I have just begun to experience hair loss, and after reading the other reviews, I feel better knowing it too will pass. Please know your reviews, including side effects, successes, and thoughts, have been a huge help. ~Thanks"

• SIM...
• Taken for less than 1 month
• June 12, 2023

For Weight Loss (Obesity/Overweight) "I have been on Mounjaro for 3 weeks (2.5 mg injection), and it has helped me tremendously. I started out at 333 lbs. Now I weigh 319 lbs. I feel full for longer. Just feel tired a lot, but I take vitamins and something for energy, so that has helped. I take stool softeners so I won't get constipated. I had a slight headache for a couple of days when I first started, but not bad. I don't crave snacks, caffeine, or sweets like I used to on a daily basis. If I even overeat a little, I feel miserable, so I have to watch that. Managing your portions is very important. I'm doing better with that now. It doesn't take much for me to eat and drink to be satisfied. My BP has been good. My doctor said I may be able to get off BP meds soon. I am so grateful for this new med. Can't wait to move up to the next dosage."

• cli...
• Taken for 1 to 6 months
• July 31, 2024

For Weight Loss (Obesity/Overweight) "I asked my doctor about starting Wegovy since my efforts weren't working, but she recommended Zepbound - and I am so glad she did! My appetite is no longer controlling me, and yet those pre-diabetic low blood sugar drops are gone. After 3 months at the 5 mg dose, I'm still consistently losing about 1% of my weight each week. The only side effects are minor constipation and heartburn, but they encourage me to drink more water. I was hesitant to start because...needles...but it's so tiny I don't feel it at all. I wish I had started sooner!"

• Ano...
• Taken for 1 to 6 months
• April 29, 2025

For Weight Loss (Obesity/Overweight) "My wife has been taking it since January this year and has lost just a hair over 50 lbs. It has done very well for her and the weight is staying off. The only side effects noticed so far are that it makes you very gassy, somewhat indigestion, and every now and then a little constipation."

• Anonymous
• Taken for 1 to 6 months
• February 16, 2025

For Weight Loss (Obesity/Overweight) "My side effects are constipation, headaches, vision is foggy, insomnia, stomach pain, nervousness, dehydration, frequent urination, bumps on my labia. It is very easy to use. I have lost 14 pounds in two months. It does cut your hunger."

• KCP...
• Taken for 1 to 6 months
• August 30, 2024

For Weight Loss (Obesity/Overweight) "Life-changing. Down 30 pounds in 5 months. Within a few hours of the first dose, I experienced hunger suppression, increased satiety, and best of all, reduced food noise. I thought about food 24/7 before taking this medication. Despite tracking calories and eating whole foods and eliminating most sugar, I always craved sweet and high-fat foods like ice cream and felt hungry even after a meal. On this medication, I crave veggies and fruit and protein. Side effects: as a woman going through menopause, the hot flashes have been miserable. I also have always had an extreme heat intolerance for hot weather. On this medication, hot flashes are gone and I've enjoyed summer for the first time in my life. Negative side effect: constipation. Easily manageable with Miralax and Benefiber."

• dem...
• Taken for 1 to 6 months
• April 28, 2025

For Weight Loss (Obesity/Overweight) "Does everything it says. I love it, the only side effect I have is extreme constipation. I've been taking it for about 5 months and down 46 lbs, and I feel much better. I have chronic pain in my lower back, but with weight loss, it helps a little."

• dmj...
• Taken for 1 to 6 months
• May 8, 2023

For Weight Loss (Obesity/Overweight) "You do lose weight, but the waves of nausea, vomiting, severe constipation, and hypoglycemia are so unpleasant, and if you escalate and find it too much - it lasts for a whole week. Consider liraglutide daily, much easier to titrate, and if you escalate and find it too much, you can lower down and only have one day of downtime."

• Eli...
• Taken for 1 to 6 months
• January 3, 2023

For Type 2 Diabetes "I have been on Mounjaro for 9 weeks. I had to jump from 5 to 10 mg last week due to shortage issues. I am having several problems with severe bloating, constipation, headache, and stomach pain. I have severe gas that keeps me up most of the night and can be a sign of impending intermittent diarrhea at times. I am always full and started pushing myself to eat as I can go all day with nothing. Now I have small welts and itching at injection sites. Total weight loss: “0.” My blood sugar is higher, especially in the morning. This drug is horrible, and I won’t put my body through it anymore. I can lose weight easier and healthier than this since it ruined my Thanksgiving, Christmas, and New Year’s Eve. I was so excited to try it and had hope. I’m thankful for all those who are benefiting from it. Good luck to all. It just wasn’t for me."

• Ano...
• Taken for less than 1 month
• April 26, 2025

For Weight Loss (Obesity/Overweight) "I am on my 5th week. Just started 5 mg Friday 04/25/25. I started 03/28/25 on the 2.5 mg. My second day I was nauseous, but nothing Sprite and Zofran couldn’t fix. Fast forward to today. I have been sleeping really well, inflammation is gone, my hunger and food noise is gone. Now I notice the day before my shot day I start to crave some, but I just drink my water to stay full. Also, a little minor constipation. I take a stool softener with my morning vitamins, which helps, plus water, water, water!! I am loving this medicine so far, I am down 10 lbs, which I don’t think that’s bad in 5 weeks."

• lif...
• Taken for 1 to 2 years
• May 23, 2024

For Type 2 Diabetes "It’s been 2 years. Yes, there were challenges. Some nausea. Lot’s of constipation. Some fatigue. And mostly good aversion. I understand fully the phrase eat to live. This medication was/is a game changer for long-time diabetes sufferers. I lost 50 pounds. Got off of insulin shots. Cholesterol meds. BP meds. I am over 60 years old and feel better than I did at 40. I would rate my experience on Mounjaro on a scale from 1-10, a solid 10. Everyone’s journey is unique, based on many different factors. I would rate my journey as successful."

• Jav...
• Taken for less than 1 month
• December 14, 2022

For Type 2 Diabetes "I had previously been on Trulicity, and the doctor switched me to Mounjaro since I have so much extra weight on me. He started me on the 5 mg pen since I had already been on Trulicity. I lost minimal weight on Trulicity. Some, but not enough to say it's awesome. The only side effect I've had on Mounjaro is occasional constipation/reflux, which is manageable. Maybe it is because I got past/thru all the nasty side effects while on Trulicity, and that minimized the effects of Mounjaro? I feel bad for all those that have had adverse effects on Mounjaro. I have lost about 10 pounds so far in just over 2 weeks, and I can tell a HUGE difference in my appetite. I mean HUGE. I'm not hungry like I used to be. In fact, this drug curbs my appetite SO much, that I have to force myself to eat sometimes, and in having to do that, it makes me instinctively want to eat more healthy food. This drug has helped with weight loss, and I am excited to see how much I will lose and get my A1C down."

• DWA...
• Taken for 1 to 6 months
• October 14, 2024

For Type 2 Diabetes "My doc insisted that I give this med a shot. My A1c was just over 7, but I am 59, 6’, and hit my heaviest weight in my life of 283.3 lbs on July 3, 2024. I started taking the 2.5 mg on July 12, 2024, and 3 months later, now at the 7.5 mg dose, I have lost 33 lbs! I do get acid reflux if I overeat (I still love food) and constipation if I don’t drink enough water, but otherwise, every Monday I give myself a shot - tired for a day and then back to normal. I had tried in the past to shed a few pounds, but nothing ever worked, so I had learned to live with it. This is some magic potion in the form of science that is giving me my life back. My goal is 225 lbs by the end of 2024 and 200 lbs in 2025. Biggest problem is my pants no longer fit!"

• Sha...
• Taken for 1 to 6 months
• December 1, 2024

For Weight Loss (Obesity/Overweight) "I started using Zepbound on October 31st of this year. The beginning dosage was 2.5 mg. I started to lose 1-3 lbs. a week. The dosage was increased to 5 mg, which I started on the 4th week. Current total loss of 11.5 lbs. My provider has suggested that I increase the dose to 7.5 mg for my next refill. I do have side effects: nausea, constipation, dry mouth. My appetite has diminished, but I have to make a conscientious effort to eat. Cravings for specific foods have gone as well. I have a fear of needles, but do not feel the injections or any discomfort associated with normal 'shots.' Overall, my experience has been a good one, but it is still early."

• Tam...
• Taken for 1 to 6 months
• February 23, 2023

For Type 2 Diabetes "I am overweight and was sent to an endocrinologist by my PCP. A1C came back 6.9, and I received the dreaded diabetes diagnosis. The endocrinologist asked me about my eating habits and suggested Mounjaro once a week injection. Sceptical I was, but I was willing to try to get my weight down and get my A1C down. First injection, no severe vomiting or anything. The only side effect I had was the constipation, I was put on a stool softener and take fiber daily, which eliminated that side effect. Within two months, I was down 15 pounds, have not given in to eating a Boston crème doughnut, on which I tend to binge, limited on my intake of food because overindulging makes me feel lousy and gives me indigestion. Within three months, my A1C is down to 5.3, and my weight is still going down. Thank you so much to the researchers who created this drug because it has saved my life and gotten me on the road to better health. The needle doesn't even hurt when I self-inject. I am grateful."

• Myk...
• Taken for 1 to 6 months
• December 20, 2024

For Weight Loss (Obesity/Overweight) "Have lost approximately 25 lbs in about 4.5 months. No major side effects. Occasional constipation, but I'm taking fiber supplement gummies, which help with regularity. Taking 7.5 mg dosage at present. Will increase to 10 mg next refill. I feel full for longer periods, which has helped control hunger bingeing. My goal would be to drop another 25-30 lbs. Still looking to start an exercise routine, which I can commit to, but life's demands interrupt my progress. I'm very grateful for this medicine."

• Ski...
• Taken for 1 to 6 months
• March 5, 2023

For Type 2 Diabetes "In November 2022, my ACI was 7.4%, and I weighed 258 pounds at 67 years old. The wake-up call was when I renewed my life insurance, a big jump in premium due to the AC1 and weight. I was now tagged as a Type 2 Diabetic. I was referred to an endocrinologist who did extensive blood work. It was agreed to go on Mounjaro 2.5 mg. The first week I suffered some side effects such as nausea, constipation, and acid burps. Within 10 days, the symptoms subsided due to stool softeners, lots of fruit (berries), and Nexium. The first month I dropped 10 pounds with no dieting, just was not hungry at all. I had no cravings, especially for sweets like cookies, donuts, and candy-all things that I used to eat. Fast forward to March 2023, I am down to 217 pounds and 20 more to go. I am now on Mounjaro 10 mg, it's a bit strong, but the results are fantastic. My AC1 is now 5.6%, which is fantastic. The bad news is nothing fits- all new suits for the spring."