Venous Thromboembolism

Medically reviewed by Drugs.com. Last updated on May 4, 2025.

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AMBULATORY CARE:

A venous thromboembolism (VTE)

is a blood clot (thrombus) that has formed in a vein. A VTE can form anywhere in your body and block blood flow. A VTE in the deep veins in the calfs, thighs, pelvis, or arms is called a deep venous thrombosis (DVT). A piece of the clot may break loose. This is called an embolus. The embolus can travel to your lungs and cause a life-threatening clot called a pulmonary embolism (PE). It is important to go to follow-up appointments and to take blood thinners as directed. Blood thinners help prevent a PE and another VTE.

Signs and symptoms

will depend on the location of the clot. You may have any of the following:

• Swelling
• Redness
• Warmth, pain, or tenderness

Call your local emergency number (911 in the US) if:

• You feel lightheaded, short of breath, and have chest pain.
• You cough up blood.

Seek care immediately if:

• Your arm or leg feels warm, tender, and painful. It may look swollen and red.

Drugs used to treat this and similar conditions

Treatment options

The following list of medications are related to or used in the treatment of this condition.

• Eliquis
• Fragmin
• Dextran 40
• Pradaxa
• apixaban

View more treatment options

Call your doctor or hematologist if:

• You have questions or concerns about your conditions or care.

Treatment for a VTE

may include any of the following:

• Blood thinners help prevent blood clots. Clots can cause strokes, heart attacks, and death. Many types of blood thinners are available. Your healthcare provider will give you specific instructions for the type you are given. The following are general safety guidelines to follow while you are taking a blood thinner:
  • Watch for bleeding and bruising. Watch for bleeding from your gums or nose. Watch for blood in your urine and bowel movements. Use a soft washcloth on your skin, and a soft toothbrush to brush your teeth. This can keep your skin and gums from bleeding. If you shave, use an electric shaver. Do not play contact sports.
  • Tell your dentist and other healthcare providers that you take a blood thinner. Wear a bracelet or necklace that says you take this medicine.
  • Do not start or stop any other medicines or supplements unless your healthcare provider tells you to. Many medicines and supplements cannot be used with blood thinners.
  • Take your blood thinner exactly as prescribed by your healthcare provider. Do not skip a dose or take less than prescribed. Tell your provider right away if you forget to take your blood thinner, or if you take too much.
• Clot busters are emergency medicines that work to dissolve blood clots. They cannot be used during pregnancy or in people with medical conditions that increase their risk of bleeding.
• A vena cava filter may be placed inside your vena cava to treat your VTE. The vena cava is a large vein that brings blood from your lower body up to your heart. The filter traps blood clots and prevents them from going into your lungs.
• Surgery called a thrombectomy may be done to remove the clot. A procedure called thrombolysis may instead be done to inject a clot buster that helps break the clot apart.

Manage a VTE:

• Wear a compression device as directed. Examples include pressure stockings, intermittent pneumatic compression, and sequential compression devices. A compression device puts pressure on your lower legs to help keep blood from pooling in your leg veins. Your healthcare provider can prescribe the right device for you. Do not buy over-the-counter devices unless your provider says it is okay. They may not fit correctly or may have elastic that cuts off your circulation. Ask your provider when to start wearing a compression device and how long to wear it.
• Elevate your legs above the level of your heart. Elevate your legs when you sit or lie down, as often as you can. This will help decrease swelling and pain. Prop your legs on pillows or blankets to keep them elevated comfortably.

Prevent another VTE:

• Maintain a healthy weight. Ask your healthcare provider what a healthy weight is for you. Ask your provider to help you create a weight loss plan if needed.
• Change your body position or move around often. Move and stretch in your seat several times each hour if you travel by car or work at a desk. In an airplane, get up and walk every hour. Move your legs by tightening and releasing your leg muscles while sitting. You can move your legs while sitting by raising and lowering your heels. Keep your toes on the floor while you do this. You can also raise and lower your toes while keeping your heels on the floor.
• Exercise regularly to help increase your blood flow. Walking is a good low-impact exercise. Talk to your healthcare provider about the best exercise plan for you.
• Do not smoke. Nicotine and other chemicals in cigarettes and cigars can damage blood vessels and make it more difficult to manage your VTE. Ask your healthcare provider for information if you currently smoke and need help to quit. E-cigarettes or smokeless tobacco still contain nicotine. Talk to your healthcare provider before you use these products.
• Ask about birth control if you take the pill. Birth control pills increases the risk for PE if you are older than 35, smoke cigarettes, or have a clotting disorder. Talk to your healthcare provider about other ways to prevent pregnancy, such as a cervical cap or intrauterine device (IUD).

Follow up with your doctor or hematologist as directed:

You may need to come in regularly for scans to check for blood clots. Your blood may checked to see how long it takes to clot. Your doctor or hematologist will tell you if you need to have this test and how often to have it. Write down your questions so you remember to ask them during your visits.

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