Anaphylaxis

Medically reviewed by Drugs.com. Last updated on May 4, 2025.

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Anaphylaxis is a life-threatening allergic reaction that must be treated immediately. Your risk for anaphylaxis increases if you have asthma or allergies. Medical conditions such as heart disease can also increase your risk. It is important to be prepared if you are at risk for anaphylaxis. Your symptoms can be worse each time you are exposed to a trigger.

DISCHARGE INSTRUCTIONS:

Steps to take for signs or symptoms of anaphylaxis:

• Immediately give 1 shot of epinephrine only into the outer thigh muscle. Even if your allergic reaction seems mild, it can quickly become anaphylaxis. This may happen even if you had a mild reaction to the allergen in the past. Each exposure can cause a different reaction. Watch for signs and symptoms of anaphylaxis every time you are exposed to a trigger. Be ready to give a shot of epinephrine. It is okay to inject epinephrine through clothing. Just be careful to avoid seams, zippers, or other parts that can prevent the needle from entering your skin.
• Leave the shot in place as directed. Your healthcare provider may recommend you leave it in place for up to 10 seconds before you remove it. This helps make sure all of the epinephrine is delivered.
• Call your local emergency number and go to the emergency department, even if the shot improved symptoms. Do not drive yourself. Bring the used epinephrine shot with you.

Call your local emergency number (911 in the US) if:

• You have a skin rash, hives, swelling, or itching.
• You have trouble breathing, shortness of breath, wheezing, or coughing.
• Your throat tightens or your lips or tongue swell.
• You have difficulty swallowing or speaking.
• You are dizzy, lightheaded, confused, or feel like you are going to faint.
• You have nausea, diarrhea, or abdominal cramps, or you are vomiting.

Seek care immediately if:

• Signs or symptoms of anaphylaxis return.

Drugs used to treat this and similar conditions

Treatment options

The following list of medications are related to or used in the treatment of this condition.

• EpiPen
• Auvi-Q
• Symjepi
• neffy
• Adrenalin

View more treatment options

Call your doctor or specialist if:

• You have questions or concerns about your condition or care.

Medicines:

• Epinephrine is medicine used to treat severe allergic reactions such as anaphylaxis. It is given as a shot into the outer thigh muscle.
• Medicines such as antihistamines, steroids, and bronchodilators decrease inflammation, open airways, and make breathing easier.
• Take your medicine as directed. Contact your healthcare provider if you think your medicine is not helping or if you have side effects. Tell your provider if you are allergic to any medicine. Keep a list of the medicines, vitamins, and herbs you take. Include the amounts, and when and why you take them. Bring the list or the pill bottles to follow-up visits. Carry your medicine list with you in case of an emergency.

Safety precautions:

• Keep 2 shots of epinephrine with you at all times. You may need a second shot, because epinephrine only works for about 20 minutes and symptoms may return. Your healthcare provider can show you and family members how to give the shot. Check the expiration date every month and replace it before it expires.
• Create an action plan. Your provider can help you create a written plan that explains the allergy and an emergency plan to treat a reaction. The plan explains when to give a second epinephrine shot if symptoms return or do not improve after the first. Give copies of the action plan and emergency instructions to family members, and work or school staff. Show them how to give a shot of epinephrine in case you are not able to give it to yourself.
• Be careful when you exercise. If you have had exercise-induced anaphylaxis, do not exercise right after you eat. Stop exercising right away if you start to develop any signs or symptoms of anaphylaxis. You may first feel tired, warm, or have itchy skin. Hives, swelling, and severe breathing problems may develop if you continue to exercise.
• Carry medical alert identification. Wear medical alert jewelry or carry a card that explains the allergy. Ask your provider where to get these items.
• Identify and avoid known triggers. Read food labels for ingredients. Look for triggers in your environment.
• Ask about treatments to prevent anaphylaxis. You may need allergy shots or other medicines to treat allergies.

Follow up with your doctor or specialist as directed:

Allergy testing may reveal allergies that can trigger anaphylaxis. Write down your questions so you remember to ask them during your visits.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

Further information

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