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Moxetumomab Pasudotox

Generic Name: Moxetumomab Pasudotox (mox e TOOM oh mab pa SOO doe tox)
Brand Name: Lumoxiti

Medically reviewed by Drugs.com. Last updated on Jul 29, 2019.

Warning

  • Capillary leak syndrome (CLS) is a very bad health problem that has happened with moxetumomab pasudotox. Sometimes, CLS can be deadly. Tell your doctor right away if you get signs of CLS like change in how much urine is passed; not able to pass urine; blood in the urine; a fast or abnormal heartbeat; chest pain or pressure; dizziness or passing out; shortness of breath; a big weight gain; swelling; throwing up blood or throw up that looks like coffee grounds; or if you have black, tarry, or bloody stools.
  • A blood problem called hemolytic uremic syndrome (HUS) has happened with moxetumomab pasudotox. Sometimes, this has been life-threatening. Call your doctor right away if you feel very tired or weak or have any bruising or bleeding, change in how much urine is passed, confusion, dark urine, fast heartbeat, fever, mood or behavior changes, pale skin, seizures, shortness of breath, stomach pain, or throwing up.
  • Talk with your doctor to see if you need to drink extra fluids while you take moxetumomab pasudotox.

Uses of Moxetumomab Pasudotox:

  • It is used to treat a type of leukemia.

What do I need to tell my doctor BEFORE I take Moxetumomab Pasudotox?

  • If you have an allergy to moxetumomab pasudotox or any part of moxetumomab pasudotox.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have kidney disease.
  • If you have ever had any of these health problems: Hemolytic uremic syndrome (HUS) or thrombotic microangiopathy (TMA).

This is not a list of all drugs or health problems that interact with moxetumomab pasudotox.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take moxetumomab pasudotox with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Moxetumomab Pasudotox?

  • Tell all of your health care providers that you take moxetumomab pasudotox. This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • You will need to have your weight and blood pressure checked as you have been told by your doctor.
  • Infusion reactions have happened with moxetumomab pasudotox. Tell your doctor if you have cough; dizziness, headache, or passing out; fast heartbeat; feeling hot; fever or chills; flushing; muscle pain; shortness of breath; upset stomach or throwing up; wheezing; or any other effects during the infusion.
  • If you are 65 or older, use moxetumomab pasudotox with care. You could have more side effects.
  • This medicine may cause harm to the unborn baby or loss of the unborn baby if you take it while you are pregnant.
  • If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting moxetumomab pasudotox. Talk with your doctor.
  • Use birth control that you can trust to prevent pregnancy while taking moxetumomab pasudotox and for 1 month after stopping moxetumomab pasudotox.
  • If you get pregnant while taking moxetumomab pasudotox or within 1 month after your last dose, call your doctor right away.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Moxetumomab Pasudotox) best taken?

Use moxetumomab pasudotox as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as an infusion into a vein over a period of time.
  • Other drugs may be given to help with infusion side effects.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Swelling.
  • Change in eyesight.
  • Numbness or tingling.
  • Low blood cell counts have happened with moxetumomab pasudotox. If blood cell counts get very low, this can lead to bleeding problems, infections, or anemia. Call your doctor right away if you have signs of infection like fever, chills, or sore throat; any unexplained bruising or bleeding; or if you feel very tired or weak.

What are some other side effects of Moxetumomab Pasudotox?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Moxetumomab Pasudotox?

  • If you need to store moxetumomab pasudotox at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time moxetumomab pasudotox is refilled. If you have any questions about moxetumomab pasudotox, please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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