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Generic Name: rho(d) immune globulin (human) (roe D ih-MYOON GLAH-byoo-lin)
Brand Name: Examples include MICRhoGAM and RhoGAM

MICRhoGAM may increase the risk of blood clots. The risk may be increased in older patients, if you will be confined to a bed or chair for a period of time, if you take estrogen products, or if you have certain catheters. The risk may also be increased if you have a condition that may increase your risk of blood clots, thick blood, heart problems, or a history of blood clots. Blood clots can occur if you do not have any of these conditions. Tell your doctor right away if you develop one-sided numbness or weakness; pain, redness, tenderness, warmth or swelling in the arms or legs; change in color of an arm or leg; chest pain or discomfort; shortness of breath; fast heartbeat; or coughing up blood. Discuss any questions or concerns with your doctor.

MICRhoGAM is used for:

Preventing certain blood problems that may occur during pregnancy or blood transfusion. It may also be used for other conditions as determined by your doctor.

MICRhoGAM is an immunoglobulin (Ig), which contains antibodies to the Rho(D) antigen. Exactly how it works is unknown.

Do NOT use MICRhoGAM if:

  • you are allergic to any ingredient in MICRhoGAM
  • you have had an allergic reaction to other human immune globulins
  • you have anti-immunoglobulin A (IgA) antibodies

Contact your doctor or health care provider right away if any of these apply to you.

Before using MICRhoGAM:

Some medical conditions may interact with MICRhoGAM. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had an allergic reaction to blood or blood products
  • if you have other blood problems (eg, anemia), bleeding problems, or IgA deficiency
  • if you are Rho(D) negative or if your spleen has been removed

Some MEDICINES MAY INTERACT with MICRhoGAM. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • Live vaccines (eg, measles, mumps, and rubella) because the effectiveness may be decreased by MICRhoGAM

This may not be a complete list of all interactions that may occur. Ask your health care provider if MICRhoGAM may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use MICRhoGAM:

Use MICRhoGAM as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • MICRhoGAM is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using MICRhoGAM at home, carefully follow the injection procedures taught to you by your health care provider.
  • If MICRhoGAM contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of MICRhoGAM, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use MICRhoGAM.

Important safety information:

  • MICRhoGAM may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to MICRhoGAM. Using MICRhoGAM alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Avoid vaccinations with live virus vaccines (eg, measles, mumps, oral polio) for 3 months after using MICRhoGAM. Vaccinations may be less effective.
  • MICRhoGAM is made from human plasma. There is an extremely low risk of developing a viral infection or Creutzfeldt-Jakob disease (CJD) after using MICRhoGAM. Discuss any questions or concerns with your doctor.
  • MICRhoGAM may affect certain lab test results. Make sure your doctor and other lab personnel know you are using MICRhoGAM.
  • LAB TESTS, including blood counts and antibody titers, may be required to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using MICRhoGAM during pregnancy. If you are or will be breast-feeding while you are using MICRhoGAM, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of MICRhoGAM:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Headache; mild fever; mild pain, swelling, or redness at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); back pain; blood in the urine; dark urine; decreased urination; fast heartbeat; nausea; severe or persistent fever; shaking and/or chills; shortness of breath; sudden weight gain; swelling; unusual tiredness or weakness; wheezing; vomiting; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dark urine; unusual tiredness or weakness; yellowing of the eyes or skin.

Proper storage of MICRhoGAM:

MICRhoGAM is usually handled and stored by a health care provider. If you are using MICRhoGAM at home, store MICRhoGAM as directed by your pharmacist or health care provider. Keep MICRhoGAM out of the reach of children and away from pets.

General information:

  • If you have any questions about MICRhoGAM, please talk with your doctor, pharmacist, or other health care provider.
  • MICRhoGAM is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take MICRhoGAM or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about MICRhoGAM. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to MICRhoGAM. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using MICRhoGAM.

Issue Date: June 3, 2015

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.