Generic Name: pancrelipase (PAN-kree-LYE-pase)
Brand Name: Examples include Creon and Zenpep
Creon is used for:
Improving food digestion in patients who cannot digest food properly because they have a pancreas problem (exocrine pancreatic insufficiency) caused by cystic fibrosis or certain other conditions.
Creon is a digestive enzyme combination. It works by helping the body to digest protein, starch, and fat.
Do NOT use Creon if:
- you are allergic to any ingredient in Creon
Contact your doctor or health care provider right away if any of these apply to you.
Before using Creon:
Some medical conditions may interact with Creon. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances (including pork proteins)
- if you have gout or high uric acid levels
- if you have a history of kidney problems, high blood sugar levels, or diabetes
- if you have a history of pancreas problems or stomach or bowel problems (eg, blockage, scarring or thickening, short bowel syndrome, Crohn disease), or if you have had bowel surgery
- if you have trouble swallowing capsules
Some MEDICINES MAY INTERACT with Creon. However, no specific interactions with Creon are known at this time.
Ask your health care provider if Creon may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Creon:
Use Creon as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Creon comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Creon refilled.
- Take Creon by mouth with each meal or snack as directed by your doctor.
- Swallow Creon whole with enough liquid to swallow it completely. Do not break, crush, chew, or hold Creon in your mouth before swallowing. Doing so may increase the risk of mouth irritation from Creon. Follow with a glass of water or juice. Contact your doctor if you experience mouth irritation while taking Creon.
- If the patient is an infant (up to 12 months old), open the capsule and sprinkle the contents into the infant's mouth or over a small amount of applesauce at room temperature. Do NOT mix Creon directly in breast milk or formula. If sprinkled onto applesauce, give the mixture to the infant right away. After giving Creon, follow it with breast milk or formula. Be sure that none of the medicine is crushed, chewed, or left in the mouth.
- If the patient is an adult or child older than 12 months old who cannot swallow the capsule whole, open it and sprinkle the contents over a small amount of acidic soft food (such as applesauce) at room temperature. Mix the medicine with the food and swallow the entire mixture right away, followed by a glass of water or juice. Be sure that none of the medicine is crushed, chewed, or left in the mouth. Check with your doctor if you are unsure which foods you may mix with Creon.
- If you miss a dose of Creon, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once or take a dose without a snack or a meal.
Ask your health care provider any questions you may have about how to use Creon.
Important safety information:
- Do NOT take more than the recommended dose without checking with your doctor.
- Do not switch between Creon and another pancreatic enzyme medicine without first checking with your doctor.
- Diabetes patients - Creon may affect your blood sugar. Check your blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Creon may increase the risk of developing a rare, serious condition called fibrosing colonopathy. When this occurs, it is usually with high doses over a long period of time. It has been most commonly reported in children with cystic fibrosis. Contact your doctor right away if you experience unusual or severe nausea, vomiting, or stomach pain; stomach bloating; or severe or persistent loose stools, constipation, or diarrhea.
- Creon comes from pork (pig) pancreas tissue. There is an extremely rare risk of developing a viral disease from this product. No cases of viral disease from pork pancreas products have been identified.
- Caution is advised when using Creon in CHILDREN; they may be more sensitive to its effects, especially fibrosing colonopathy.
- PREGNANCY and BREAST-FEEDING: It is not known if Creon can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Creon while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use Creon, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Creon:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; decreased appetite; dizziness; gas; headache; irritability; mild diarrhea; sore throat or cough; stomach pain; vomiting; weight loss.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); mouth irritation; painful, swollen joints; severe or persistent loose stools, diarrhea, or constipation; severe or unusual nausea, vomiting, or stomach pain; stomach bloating.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Creon:
Store Creon at room temperature up to 77 degrees F (25 degrees C). Avoid heat. Brief storage at temperatures between 59 and 104 degrees F (15 and 40 degrees C) is permitted. Keep the bottle tightly closed. Store in the original container away from heat, moisture, and light. Do not remove any moisture control packs that may come in the bottle. Do not store in the bathroom. Keep Creon out of the reach of children and away from pets.
- If you have any questions about Creon, please talk with your doctor, pharmacist, or other health care provider.
- Creon is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Creon or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Creon. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Creon. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Creon.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about Creon (pancrelipase)
- Side Effects
- During Pregnancy
- Dosage Information
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- Drug Interactions
- Support Group
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- Drug class: digestive enzymes