Generic Syfovre Availability

Last updated on Aug 7, 2024.

Syfovre is a brand name of pegcetacoplan ophthalmic, approved by the FDA in the following formulation(s):

SYFOVRE (pegcetacoplan - solution;intravitreal)

Manufacturer: APELLIS PHARMS
Approval date: February 17, 2023
Strength(s): 15MG/0.1ML (15MG/0.1ML) ^[RLD]

Has a generic version of Syfovre been approved?

No. There is currently no therapeutically equivalent version of Syfovre available in the United States.

Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Syfovre. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.

Related patents

Patents are granted by the U.S. Patent and Trademark Office at any time during a drug's development and may include a wide range of claims.

Cell-reactive, long-acting, or targeted compstatin analogs and related compositions and methods
Patent 10,035,822
Issued: July 31, 2018
Inventor(s): Francois Cedric & Deschatelets Pascal
Assignee(s): Apellis Pharmaceuticals, Inc.
Long-acting compstatin analogs comprising a clearance-reducing moiety attached to two compstatin analog moieties, each compstatin analog moiety comprising a cyclic peptide extended by a lysine residue or a sequence comprising a lysine residue at the N-terminus, C-terminus, or both, wherein the lysine residue is separated from the cyclic portion of the peptide by a rigid or flexible spacer comprising an oligo(ethylene glycol) moiety, the clearance reducing moiety comprises a linear polymer, wherein each end of the linear polymer is linked to one of the compstatin analog moieties by way of a carbamate, wherein (i) the spacer comprises —(CH2)— and —(O—CH2-CH2—)joined covalently, wherein m is between 1 and 10 and n is between 1 and 10; and/or (ii) the spacer comprises 8-amino-3,6-dioxaoctanoic acid (AEEAc) or 11-amino-3,6,9-trioxaundecanoic acid.
Patent expiration dates:
- November 15, 2033
  ✓
  Drug substance
Cell-reactive, long-acting, or targeted compstatin analogs and uses thereof
Patent 10,125,171
Issued: November 13, 2018
Inventor(s): Francois Cedric & Deschatelets Pascal
Assignee(s): Apellis Pharmaceuticals, Inc.
In some aspects, the present invention provides cell-reactive compstatin analogs and compositions comprising cell-reactive compstatin analogs. In some aspects, the invention further provides methods of using cell-reactive compstatin analogs, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ. In some aspects, the invention provides long-acting compstatin analogs and compositions comprising long-acting compstatin analogs. In some aspects, the invention further provides methods of using long-acting compstatin analogs, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ. In some aspects, the invention provides targeted compstatin analogs and compositions comprising targeted compstatin analogs. In some aspects, the invention further provides methods of using targeted compstatin analogs, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ.
Patent expiration dates:
- August 2, 2033
  ✓
  Drug substance
Cell-reactive, long-acting, or targeted compstatin analogs and related compositions and methods
Patent 10,875,893
Issued: December 29, 2020
Inventor(s): Francois Cedric & Deschatelets Pascal
Assignee(s): Apellis Pharmaceuticals, Inc.
In some aspects, the present invention provides compositions and methods of treatment comprising long-acting compstatin analogs. In some aspects, long-acting compstatin analogs comprise a clearance-reducing moiety attached to two compstatin analog moieties, wherein each compstatin analog moiety comprises a cyclic peptide comprising the amino acid sequence as set forth in SEQ ID NO: 28 extended by a lysine residue or a sequence comprising a lysine residue at the N-terminus, C-terminus, or both, wherein the lysine residue is separated from the cyclic portion of the peptide by a spacer comprising 8-amino-3,6-dioxaoctanoic acid (AEEAc) moiety, the clearance reducing moiety comprises a polymer, wherein each end of the polymer is linked to one of the compstatin analog moieties by way of a linker moiety that is or comprises a carbamate, and wherein the polymer is a PEG having an average molecular weight of about 40 kDa.
Patent expiration dates:
- November 15, 2033
  ✓
  Patent use: TREATMENT OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION BY INTRAVITREAL ADMINISTRATION OF PEGCETACOPLAN
  ✓
  Drug substance
Cell-reactive, long-acting, or targeted compstatin analogs and related compositions and methods
Patent 11,292,815
Issued: April 5, 2022
Inventor(s): Francois Cedric & Deschatelets Pascal
Assignee(s): Apellis Pharmaceuticals, Inc.
In some aspects, the present invention provides compositions and methods (e.g. methods of treating, preventing, making, etc.) comprising compstatin analogs. In some embodiments, compstatin analogs comprise a linear PEG moiety having a molecular weight of 40 kDa and coupled to each of two compstatin analog moieties; wherein each compstatin analog moiety is a CA28-AEEAc-Lys moiety, the linear PEG moiety is coupled to the Lys side chain of each CA28-AEEAc-Lys moiety via a carbamate and each CA28-AEEAc-Lys moiety is Ac-Ile-Cys*-Val-(1Me)Trp-Gln-Asp-Trp-Gly-Ala-His-Arg-Cys*-Thr-[NH-CH2CH2OCH2CH2OCH2-C(═O)]-Lys-NH2 (SEQ ID NO: 51); wherein the Cys* groups are joined by a disulfide bond.
Patent expiration dates:
- November 15, 2033
  ✓
  Patent use: TREATMENT OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION BY INTRAVITREAL ADMINISTRATION OF PEGCETACOPLAN
  ✓
  Drug substance
  ✓
  Drug product
Patent 11,661,441
Patent expiration dates:
- January 13, 2033
  ✓
  Patent use: TREATMENT OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION BY INTRAVITREAL ADMINISTRATION OF PEGCETACOPLAN
  ✓
  Drug substance
Patent 11,903,994
Patent expiration dates:
- February 22, 2037
  ✓
  Patent use: TREATMENT OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION BY INTRAVITREAL ADMINISTRATION OF 15 MG PEGCETACOPLAN EVERY OTHER MONTH
- February 22, 2037
  ✓
  Patent use: TREATMENT OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION BY INTRAVITREAL ADMINISTRATION OF 15 MG PEGCETACOPLAN MONTHLY
- February 22, 2037
  ✓
  Patent use: TREATMENT OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION BY INTRAVITREAL ADMINISTRATION OF 15 MG PEGCETACOPLAN MONTHLY OR EVERY OTHER MONTH
Patent 7,888,323
Patent expiration dates:
- December 4, 2027
  ✓
  Drug substance
Patent 7,989,589
Patent expiration dates:
- December 4, 2027
  ✓
  Drug substance
Methods of treating age-related macular degeneration by compstatin and analogs thereof
Patent 8,168,584
Issued: May 1, 2012
Inventor(s): Deschatelets Pascal & Olson Paul & Francois Cedric
Assignee(s): Potentia Pharmaceuticals, Inc.
The present invention features the use of compstatin and complement inhibiting analogs thereof for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, choroidal neovascularization, and/or retinal neovascularization. The invention also provides compositions comprising compstatin or a complement inhibiting analog thereof and a second therapeutic agent. The invention also provides compositions comprising compstatin or a complement inhibiting analog thereof and a gel-forming material, e.g., soluble collagen, and methods of administering the compositions.
Patent expiration dates:
- April 7, 2027
  ✓
  Patent use: TREATMENT OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION BY INTRAVITREAL ADMINISTRATION OF PEGCETACOPLAN
- April 7, 2027
  ✓
  Patent use: TREATMENT OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION BY INTRAVITREAL ADMINISTRATION OF PEGCETACOPLAN AND ALSO ADMINISTERING AN ANTI-VEGF AGENT
Method of treating age-related macular degeneration comprising administering a compstatin analog
Patent 9,056,076
Issued: June 16, 2015
Inventor(s): Deschatelets Pascal & Olson Paul & Francois Cedric
Assignee(s): Potentia Pharmaceuticals, Inc.
The present invention features the use of compstatin and complement inhibiting analogs thereof for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, choroidal neovascularization, and/or retinal neovascularization. The invention also provides compositions comprising compstatin or a complement inhibiting analog thereof and a second therapeutic agent. The invention also provides compositions comprising compstatin or a complement inhibiting analog thereof and a gel-forming material, e.g., soluble collagen, and methods of administering the compositions.
Patent expiration dates:
- October 25, 2026
  ✓
  Patent use: TREATMENT OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION BY INTRAVITREAL ADMINISTRATION OF PEGCETACOPLAN
Potent compstatin analogs
Patent 9,169,307
Issued: October 27, 2015
Inventor(s): Lambris John D. & Katragadda Madan
Assignee(s): The Trustees of the University of Pennsylvania
Compounds comprising peptides and peptidomimetics capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display greatly improved complement activation-inhibitory activity as compared with currently available compounds.
Patent expiration dates:
- November 18, 2027
  ✓
  Patent use: TREATMENT OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION BY ADMINISTERING COMPLEMENT INHIBITOR PEGCETACOPLAN
  ✓
  Drug substance

Related exclusivities

Exclusivity is exclusive marketing rights granted by the FDA upon approval of a drug and can run concurrently with a patent or not. Exclusivity is a statutory provision and is granted to an NDA applicant if statutory requirements are met.

Exclusivity expiration dates:
- February 22, 2026 - NEW PRODUCT
- May 14, 2026 - NEW CHEMICAL ENTITY

More about Syfovre (pegcetacoplan ophthalmic)

Patient resources

Syfovre drug information

Professional resources

Related treatment guides

Glossary

Term	Definition
Drug Patent	A drug patent is assigned by the U.S. Patent and Trademark Office and assigns exclusive legal right to the patent holder to protect the proprietary chemical formulation. The patent assigns exclusive legal right to the inventor or patent holder, and may include entities such as the drug brand name, trademark, product dosage form, ingredient formulation, or manufacturing process A patent usually expires 20 years from the date of filing, but can be variable based on many factors, including development of new formulations of the original chemical, and patent infringement litigation.
Drug Exclusivity	Exclusivity is the sole marketing rights granted by the FDA to a manufacturer upon the approval of a drug and may run simultaneously with a patent. Exclusivity periods can run from 180 days to seven years depending upon the circumstance of the exclusivity grant.
RLD	A Reference Listed Drug (RLD) is an approved drug product to which new generic versions are compared to show that they are bioequivalent. A drug company seeking approval to market a generic equivalent must refer to the Reference Listed Drug in its Abbreviated New Drug Application (ANDA). By designating a single reference listed drug as the standard to which all generic versions must be shown to be bioequivalent, FDA hopes to avoid possible significant variations among generic drugs and their brand name counterpart.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Drug Status

Availability Prescription only Rx

Pregnancy & Lactation Risk data available

CSA Schedule* Not a controlled drug N/A

Approval History Drug history at FDA

User Reviews & Ratings

3 Reviews

Images

Pill medicine is Syfovre 15 mg / 0.1 mL injection for intravitreal use — Syfovre 15 mg / 0.1 mL injection for intravitreal use