Generic Giapreza Availability

Last updated on May 7, 2025.

Giapreza is a brand name of angiotensin II, approved by the FDA in the following formulation(s):

GIAPREZA (angiotensin ii acetate - solution;intravenous)

Manufacturer: LA JOLLA PHARMA
Approval date: December 21, 2017
Strength(s): EQ 2.5MG BASE/ML (EQ 2.5MG BASE/ML) ^[RLD], EQ 5MG BASE/2ML (EQ 2.5MG BASE/ML) (discontinued) ^[RLD]
Manufacturer: LA JOLLA PHARMA
Approval date: December 23, 2021
Strength(s): EQ 0.5MG BASE/ML (EQ 0.5MG BASE/ML) ^[RLD]

Is there a generic version of Giapreza available?

No. There is currently no therapeutically equivalent version of Giapreza available in the United States.

Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Giapreza. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.

Related patents

Patents are granted by the U.S. Patent and Trademark Office at any time during a drug's development and may include a wide range of claims.

Angiotensin II alone or in combination for the treatment of hypotension
Patent 10,028,995
Issued: July 24, 2018
Inventor(s): Chawla Lakhmir
Assignee(s): The George Washington University a Congressionally Chartered Not-for-Profit Corporation
The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 65 mm or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.
Patent expiration dates:
- December 18, 2034
  ✓
  Patent use: MAINTAINING MEAN ARTERIAL PRESSURE OF ABOUT 65 MMHG OR ABOVE WITH ABOUT 1 NG/KG/MIN TO ABOUT 40 NG/KG/MIN ANGIOTENSIN II IN HYPOTENSIVE PATIENTS TREATED WITH VASOPRESSIN OR A VASOPRESSIN ANALOGUE AND REDUCING VASOPRESSIN OR VASOPRESSIN ANALOGUE USE
Method of treating low blood pressure
Patent 10,335,451
Issued: July 2, 2019
Inventor(s): Chawla Lakhmir
Assignee(s): The George Washington University a Congressionally Chartered Not-for-Profit Corporation
A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of Angiotensin II, or Ang II, to the patient.
Patent expiration dates:
- December 16, 2029
  ✓
  Patent use: TREATING HYPOTENSION WITH ABOUT 20 NG/KG/MIN TO ABOUT 40 NG/KG/MIN ANGIOTENSIN II IN A HUMAN SUBJECT HAVING SEPTIC SHOCK
Angiotensin II alone or in combination for the treatment of hypotension
Patent 10,493,124
Issued: December 3, 2019
Inventor(s): Chawla Lakhmir S.
Assignee(s): The George Washington University a Congressionally Chartered Not-for-Profit Corporation
The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 65 mm Hg or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm Hg to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.
Patent expiration dates:
- December 18, 2034
  ✓
  Patent use: TREATING LOW BLOOD PRESSURE WITH ANGIOTENSIN II AT AN INITIAL RATE OF ABOUT 20 NG/KG/MIN AND TITRATING DOWN TO ACHIEVE AND/OR MAINTAIN A MAP OF ABOUT 65 MM HG OR ABOVE
Method of treating low blood pressure
Patent 10,500,247
Issued: December 10, 2019
Inventor(s): Chawla Lakhmir
Assignee(s): The George Washington University a Congressionally Chartered Not-for-Profit Corporation
A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of Angiotensin II, or Ang II, to the patient.
Patent expiration dates:
- December 16, 2029
  ✓
  Patent use: TREATING LOW BLOOD PRESSURE WITH ANGIOTENSIN II WITH AN INITIAL RATE OF ABOUT 5 NG/KG/MIN TO ABOUT 20 NG/KG/MIN IN A SUBJECT HAVING REFRACTORY HYPOTENSION OR SEVERE HYPOTENSION
- December 16, 2029
  ✓
  Patent use: TREATING LOW BLOOD PRESSURE WITH ANGIOTENSIN II WITH AN INITIAL RATE OF ABOUT 5 NG/KG/MIN TO ABOUT 20 NG/KG/MIN IN A SUBJECT HAVING REFRACTORY HYPOTENSION OR SEVERE HYPOTENSION, AND TITRATING THE RATE UP
Method of treating low blood pressure
Patent 10,548,943
Issued: February 4, 2020
Inventor(s): Chawla Lakhmir S.
Assignee(s): The George Washington University a Congressionally Chartered Not-for-Profit Corporation
A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of Angiotensin II, or Ang II, to the patient.
Patent expiration dates:
- December 16, 2029
  ✓
  Patent use: INCREASING BLOOD PRESSURE WITH AN INITIAL RATE OF ABOUT 20 NG/KG/MIN ANGIOTENSIN II IN A HUMAN SUBJECT HAVING SEPTIC SHOCK, AND TITRATING THE RATE UP.
- December 16, 2029
  ✓
  Patent use: INCREASING BLOOD PRESSURE WITH A RATE OF ABOUT 20 NG/KG/MIN TO ABOUT 40 NG/KG/MIN ANGIOTENSIN II IN A HUMAN SUBJECT HAVING SEPTIC SHOCK
Angiotensin II alone or in combination for the treatment of hypotension
Patent 11,096,983
Issued: August 24, 2021
Inventor(s): Chawla Lakhmir S.
Assignee(s): The George Washington University a Congressionally Chartered Not-for-Profit Corporation
The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 6.5 mm Hg or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm Hg to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.
Patent expiration dates:
- December 18, 2034
  ✓
  Patent use: TREATING DISTRIBUTIVE SHOCK WITH ANGIOTENSIN II
- December 18, 2034
  ✓
  Patent use: TREATING SEPTIC SHOCK WITH ANGIOTENSIN II
Methods for treating hypotension in a patient that has received an ACE inhibitor by administering angiotensin II
Patent 11,219,662
Issued: January 11, 2022
Inventor(s): Tidmarsh George & Chawla Lakhmir
Assignee(s): La Jolla Pharma, LLC
The present disclosure relates to the use of angiotensin II, angiotensin III, or angiotensin IV in therapeutic methods for the treatment of hypotension, especially catecholamine-resistant hypotension.
Patent expiration dates:
- January 6, 2037
  ✓
  Patent use: TREATING HYPOTENSION WITH ANGIOTENSIN II IN A PATIENT RECEIVING AN ANGIOTENSIN CONVERTING ENZYME INHIBITOR
Angiotensin II alone or in combination for the treatment of hypotension
Patent 11,559,559
Issued: January 24, 2023
Inventor(s): Chawla; Lakhmir S.
Assignee(s): The George Washington University, A Congressionally Chartered Not-For-Profit Corporation (Washington, DC)
The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 65 mm Hg or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm Hg to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.
Patent expiration dates:
- December 18, 2034
  ✓
  Patent use: INCREASING BLOOD PRESSURE IN A PATIENT HAVING DISTRIBUTIVE SHOCK
Angiotensin II alone or in combination for the treatment of hypotension
Patent 9,220,745
Issued: December 29, 2015
Inventor(s): Chawla Lakhmir
Assignee(s): The George Washington University, a Congressionally Not-for-Profit Corporation
The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 65 mm Hg or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm Hg to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.
Patent expiration dates:
- December 18, 2034
  ✓
  Patent use: TREATING HIGH OUTPUT SHOCK WITH ANGIOTENSIN II BY INCREASING MEAN ARTERIAL PRESSURE IN PATIENTS TREATED WITH CATECHOLAMINES AND REDUCING CATECHOLAMINE USE
- December 18, 2034
  ✓
  Patent use: MAINTAINING MEAN ARTERIAL PRESSURE OF ABOUT 65 MMHG OR HIGHER WITH ANGIOTENSIN II IN SHOCK PATIENTS TREATED WITH CATECHOLAMINES AND REDUCING CATECHOLAMINE USE
Method of treating low blood pressure
Patent 9,572,856
Issued: February 21, 2017
Inventor(s): Chawla Lakhmir
Assignee(s): The George Washington University a Congressionally Chartered Not-for-Profit Corporation
A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of Angiotensin II, or Ang II, to the patient.
Patent expiration dates:
- July 18, 2031
  ✓
  Patent use: TREATING REFRACTORY HYPOTENSION WITH ABOUT 20 NG/KG/MIN ANGIOTENSIN II IN A PATIENT RECEIVING VASOPRESSOR
- November 20, 2030
  ✓
  Patent use: TREATING REFRACTORY HYPOTENSION WITH ABOUT 20 NG/KG/MIN ANGIOTENSIN II IN A PATIENT RECEIVING VASOPRESSOR
Method of treating low blood pressure
Patent 9,867,863
Issued: January 16, 2018
Inventor(s): Chawla Lakhmir
Assignee(s): The George Washington University a Congressionally Chartered Not-for-Profit Corporation
A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of Angiotensin II, or Ang II, to the patient.
Patent expiration dates:
- December 16, 2029
  ✓
  Patent use: TREATING REFRACTORY HYPOTENSION WITH ABOUT 5 NG/KG/MIN TO ABOUT 20 NG/KG/MIN ANGIOTENSIN II IN A PATIENT RECEIVING VASOPRESSOR

More about Giapreza (angiotensin II)

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Glossary

Term	Definition
Drug Patent	A drug patent is assigned by the U.S. Patent and Trademark Office and assigns exclusive legal right to the patent holder to protect the proprietary chemical formulation. The patent assigns exclusive legal right to the inventor or patent holder, and may include entities such as the drug brand name, trademark, product dosage form, ingredient formulation, or manufacturing process A patent usually expires 20 years from the date of filing, but can be variable based on many factors, including development of new formulations of the original chemical, and patent infringement litigation.
Drug Exclusivity	Exclusivity is the sole marketing rights granted by the FDA to a manufacturer upon the approval of a drug and may run simultaneously with a patent. Exclusivity periods can run from 180 days to seven years depending upon the circumstance of the exclusivity grant.
RLD	A Reference Listed Drug (RLD) is an approved drug product to which new generic versions are compared to show that they are bioequivalent. A drug company seeking approval to market a generic equivalent must refer to the Reference Listed Drug in its Abbreviated New Drug Application (ANDA). By designating a single reference listed drug as the standard to which all generic versions must be shown to be bioequivalent, FDA hopes to avoid possible significant variations among generic drugs and their brand name counterpart.

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Drug Status

Availability Prescription only Rx

Pregnancy & Lactation Risk data available

CSA Schedule* Not a controlled drug N/A

Approval History Drug history at FDA

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