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Can you take trazodone and amitriptyline together?

8 Answers

Nitro061 31 Oct 2018

Yes I take 200 mg each at night

Votes: +0
RationalGaze 28 Oct 2018

I'm kind of wondering the same thing. I have been prescribed both for sleep trouble. They each help a little, however, trazodone seems to help with my sleep apnea, and amitriptyline helps with muscle spasms I sometimes get in my back. So each has it's benefits, but I'm hesitant to take them together.

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Jensimp 20 March 2018

I take 150mg of trazodone and Ambien 10mg, and amitriptyline 75mg to help me fall asleep and stay asleep. It works good for falling asleep but sleep soundly for only 4 hours.

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cindym70 11 April 2013

Yes, I've done so for years. But I take them in low dose and take it at night because i do have side effects such as dizziness, fogginess, etc. Which is why i only take them at night. By the morning, all side effects are gone. Helps me sleep and helps with headaches. It's a winning combination. I take 25mg amitripyline and 50mg trazodone. Good luck.

Votes: +1
MDGirl 17 Nov 2012

A rheumatologist at Johns Hopkins prescribed both to me. Trazodone for sleeping and Amitriptyline for headaches. My primary doctor also with Hopkins said not to take both. I wasn't told why but I read about serotonin syndrome. I was put on something else for headaches.

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Inactive 11 Nov 2012

Combining these medications can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood...

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Take care,


Votes: +1
kaismama 11 Nov 2012

I'm at a loss as to why you would want to. They are the same kind of drug.

Votes: +0
Inactive 11 Nov 2012

Hello cecini. No. Not recommended. (The risk factors run high) Unless your doctor feels the benefits out weigh the risks. regards pledge

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