What is if I take linaclotide with pantoprazole and after one hour eat prednisolone 50 mg?
Question posted by drforouzan on 1 day 11 hours ago
Last updated on 21 July 2025 (15 hours ago) by messdeck
I’m a 31-year-old woman with wAIHA. Currently, I take: - Morning: Pantoprazole 40 mg, then 50 mg prednisolone with breakfast after 1 hour. - Noon: Fluoxetine 10 mg + chlordiazepoxide 10 mg. - Afternoon: Symbicort inhaler. - 7 PM: Pantoprazole 40 mg again, followed by 10 mg rivaroxaban with dinner after 1 hour. - 12 AM: Folic acid 5 mg + Symbicort.
I’ve had chronic constipation, and now steroid-induced joint pain limits my exercise. Laxatives don’t help—my stool is very hard/thick, and straining is severe. I want to start low-dose linaclotide in the morning (under supervision) but worry about interactions with pantoprazole/prednisolone: 1. How significant are these interactions? Could linaclotide reduce prednisolone’s bioavailability? 2. About syncope/fainting: Is it only diarrhea-related, or can it occur during defecation (vagus nerve effect)? I need safe, low-risk bowel movements. 3. How common is syncope with linaclotide? Does taking it 1 hour apart from prednisolone increase the risk?
The information on this page reflects personal experiences shared by our community members. It is not reviewed for medical accuracy and should not replace professional medical advice.
Answers
ME
messdeck
16 hours ago
Have you noticed you've taken the word drforouzan as your name. This appears to be an error on your part. I did look up the word WAIHA and it means Warm Autoimmune Hemolytic Anemia. I've read your explanation which complains about constipation. There are many drugs involved, all this is a very complex situation as far as I can see. I'M NOT A DOCTOR. I assume you are under a doctor's care. I recommend you talk to him and explain your suffering. If this constipation continues, I recommend you visit the hospital emergency room (ER). The ER is a service that will help you to understand how to solve your constipation and take action to improve your situation. Be sure to tell your doctor and the ER doctor about ALL the medications you're taking.
