Ten or fifteen years ago, a pharmacist gave me a pharmaceutical paper (lost now) dealing with muscular pain (e.g., back pain)to take the fullest advantage of the NSAID effect of ibuprofen. The paper claimed that taking occasional ibuprofen only masked the pain, whereas taking 2.5-3.0 grams in the course of a day for 4-5 days gives a better chance of allowing the NSAID effect to kick in. Any references and/or recommendations on this?
Dear prov 356, I researched your question and from what I can tell there are a lot of different answers out there... the most common one was to take 800mgs 3 times a day, and after 4 or 5 days you should start to notice a difference. Now I would be careful doing this, because this drug can cause your stomach to bleed, and you would not know it for a while. I had a friend's dad die from his stomach bleeding, so please be very careful... Good Luck
I've heard this said also, from a pharmacist. On MedicineNet I've found the following: "Pain, fever, and inflammation are promoted by the release in the body of chemicals called prostaglandins. Ibuprofen blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower levels of prostaglandins. As a consequence, inflammation, pain and fever are reduced."
Also, ".In certain conditions (e.g., arthritis), it may take up to two weeks, taken regularly, before the full benefits of this drug take effect. If you are taking this drug on an "as needed" basis (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has significantly worsened, the medicine may not work as well."
These were found at: http://www.medicinenet.com/ibuprofen-oral/article.htm and seem to coincide with what you read, and what I was advised: That the best relief came from using NSAIDS over a period of time, as the prostaglandins that cause inflammation are reduced. Be careful though: NSAIDS can cause heart problems and stroke, also gastrointestinal problems if used over a long period of time. Always contact your doctor if there is any doubt about a medication. Take care -
The thing with any NSAID type medications is to keep a consistant level of medication in your system. That being said, try starting at a lower dose of 400mg at three times a day and increase to 600mg to 800mg only as needed. Be sure to take it with food to be sure that your stomach is protected. The key is the consistancy of the medication of the dosing taking it at the 8 hour intervals for at least 2 weeks and increasing the dose only when your need to. Good luck and I hope it helps.
- Ibuprofen Information for Consumers
- Ibuprofen Information for Healthcare Professionals (includes dosage details)
- Side Effects of Ibuprofen (detailed)
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