I read a review on this site from someone who found that adding wellbutrin to venlafaxine was helpful. I've been extremely depressed, as in doing nothing, even activities that are extremely enjoyable to me. Years ago wellbutrin seemed to help me get up and go. effexor (also taken in the past, but not concurrently with wellbutrin) gave me some help with depression). I have been for some time now in a very nerve wracking home situation, and need to get better to help myself deal with that situation. I have panic disorder and anxiety disorder also.