Can you take venlafaxine & mirtazapine together or is it a bad mix?

Interactions between your drugs
Major
venlafaxine mirtazapine
Applies to: venlafaxine, mirtazapine

Using venlafaxine together with mirtazapine can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. You should seek immediate medical attention if you experience these symptoms while taking the medications. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Plus there is a therapeutic duplication meaning you are on two antidepressants and the recommended number of antidepressants you should be on is one.

Interaction check: https://www.drugs.com/interactions-check.php?drug_list=2296-0,1640-0

I suggest you discuss the possibility of taking Melatonin instead of Mirtazapine for sleep, by the way Melatonin and Venlafaxine do not interact and in my opinion is a safer choice.

Interaction check: https://www.drugs.com/interactions-check.php?drug_list=2296-0,1548-10148