Hi, it really isn't a good idea to drink whilst you are taking Tramadol, even if you take a 'day off', the medication it stays in your system for quite a while. I mixed the 2 in the past and i was violently sick. Also check out the interaction report via the following link: https://www.drugs.com/interactions-check.php?drug_list=2221-0,1034-14582
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