Can I take tramadol with these antidepressants?

Your pharmacist won't say anything (I took antidepressants with it, they said nothing), but depending on the doses of Tramadol and Cymbalta, there is a chance of serotonin syndrome. Tramadol can lower the seizure threshold in certain individuals. The Buspar and Seroquel won't really factor in, but the Cymbalta might.

I was on Tramadol but had to stop when I started Lexapro. I did research and could not find any anti-depressants that could be safely taken with Tramadol. I had to switch to Lortab for my pain.

Hi, this is what the Drugs.com Interactions Checker says:

https://www.drugs.com/interactions-check.php?drug_list=2221-0,441-206,949-2273,1979-1274

I would have to advise you to consider an alternative analgesic as there are several warnings of moderate to severe interaction risks. Please speak with your doctor about your options...

Hi, Basketballer! There are several moderate to major interaction warnings with these drugs. Be sure your doctor(s) are aware of exactly what you are taking and what dosages. Be sure to follow prescribing directions exactly and be aware of the indications of a possible interaction.

https://www.drugs.com/interactions-check.php?drug_list=2221-0,441-206,949-2273,1979-1274