I’m taking Xanax 2mg per day for anxiety. I have MDD, and have tried 20 different antidepressants. I want to ask my doctor to put me on tramadol to raise my dopamine, and I wonder how much I can take without a dangerous combination. Can I take 50 mg of Tramadol and 2 mg of Xanax without a major problem? I am pretty sure I have taken them together before, when I had an accident at work and hurt my back.