Tradjenta - How long do you normally have to be on the medication before it works?

Linagliptin is a DPP-4 Inhibitor. These drugs work to block the enzyme responsible for the breakdown of a specific gut hormone that helps the body produce more insulin when blood glucose is high and reduces the amount of glucose produced by the liver. This inhibitor usually demonstrates its full effect in about a week. "It’s blocking that enzyme after the first dose a little bit, but by the time you get out to dose five, you’re blocking the majority of that enzyme,” (Sam Ellis, PharmD, BCPS, CDE, associate professor in the Department of Clinical Pharmacy at the University of Colorado)